Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris
It was found that in a study of 20,000 people our results showed that the prevalence of angina was 3 times more in iciHHV-6+ people than those who did not have a copy of the virus. It also showed that iciHHV-6+ may contribute to the development of angina.
Are Physical Activity Levels Linked to Nutrient Adequacy? Implications for Cancer Risk
This study showed that higher PAL would promote better health and have DRIs which would help promote potential cancer-preventing nutrients. Benefits of higher PAIs may extend beyond the usual benefits attributed to physical activity.
Recombination affects accumulation of damaging and disease-associated mutations in human populations
Using high-coverage sequencing data from over 1,400 individuals in the 1000 Genomes and CARTaGENE projects, we show that recombination rate modulates the distribution of putatively deleterious variants across the entire human genome.
Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals
They wanted to determine if there was an association with height, arterial stiffness, and bone fractures. They were able to determine at the end of the study that those with shorter statures were more likely to have arterial stiffness and hypertension.
Leisure-Time Physical Activity Does not Attenuate the Association Between Occupational Sedentary Behavior and Obesity: Results From Alberta’s Tomorrow Project.
Using ATP data, this study determined that those in sedendary jobs are more at higher risk of obesity and was not attenuated by physical activity. Women did not show the same risk with sedendary behaviour.
The Sedentary Time and Activity Reporting Questionnaire (STAR-Q): reliability and validity against doubly labeled water and 7-day activity diaries.
The research team put together a STAR-Q to estimate past-month energy expenditure. They looked at 102 adults over a two week period. The STAR-Q demonstrated substantial validity for estimating occupational sedentary time and strenuous activity and fair validity for ranking individuals by AEE.
Conditions Associated with Circulating Tumor-Associated Folate Receptor 1 Protein in Healthy Men and Women
This article examined how FOLR1 protein could potentially be way to detect early cancer. The team used electrochemical luminescence immunoassay. The study concluded that they should use caution when saying that serum FOLR1 can detect early cancer as there has not been a study with enough evidence to truly determine that.
Geostatistical modelling of arsenic in drinking water wells and related toenail arsenic concentrations across Nova Scotia, Canada.
This paper looked at the spatial variation of toenail arsenic concentration, they found that because of geological and environmental contaminants in well water there are higher levels of arsenic concentraion in human bodies.
Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy
These data describe a novel KCC2 variant significantly associated with a human disease and suggest genetically encoded impairment of KCC2 functional regulation may be a risk factor for the development of human IGE.
High-Resolution Genomic Analysis of Human Mitochondrial RNA Sequence Variation
The researchers sequenced ~1000 individuals mitochondrial RNA and a significant variation of sequences that show patterns of posttranscriptional modication. CARTaGENE samples were used to identify this information.