Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2021

Examining the etiology of early-onset breast cancer in the Canadian Partnership for Tomorrow’s Health (CanPath)

Authors: Joy Pader, Robert Basmadjian, Dylan O'Sullivan, Nicole Mealey, Yibing Ruan, Christine Friedenreich, Rachel Murphy, Edwin Wang, May Lynn Quan, Darren Brenner

The objective of this study was to investigate relationships between modifiable and non-modifiable risk factors and early-onset breast cancer among the BC Generations Project, Alberta’s Tomorrow Project and Ontario Health Study. In this study, measures of adiposity, pregnancy history, and familial history of breast cancer are important risk factors for early-onset breast cancer.

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2021

A Prospective Analysis of Plasma Phospholipid Fatty Acids and Breast Cancer Risk in 2 Provinces in Canada

Authors: Marnie Newell, Sunita Ghosh, Susan Goruk, Mohammedreza Pakseresht, Jennifer Vena, Trevor Dummer, Catherine Field

This study compared participants from BCGP and ATP and examined whether there was an association between fatty acid status and the risk of breast cancer, including location, menopausal status, and waist-to-hip ratio as key variables. Findings suggest that regional variations in fatty acid status influence breast cancer risk and highlights the complexity and difficulty in using fatty acid status to predict breast cancer risk in diverse populations without the consideration of other risk factors.

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2020

Diabetes, Brain Infarcts, Cognition and Small Vessels in the Canadian Alliance for Healthy Hearts and Minds Study

Authors: Hertzel Gerstein, Eric Smith, Chinthanie Ramasundarahettige, Dipika Desai, Philip Awadalla, Philippe Broet, Sandra Black, Trevor Dummer, Jason Hicks, Alan Moody, Jean-Claude Tardif, Koon Teo, Jennifer Vena, Salim Yusuf, Douglas Lee, Matthias Friedrich, Sonia Anand

The CAHHM study collected brain and carotid magnetic resonance imaging (MRI) and two cognitive tests (DSST and MoCA) in a cross-sectional sample of 7,733 men and women. It was concluded that small vessel disease characterizes much of the relationship between diabetes and vascular brain injury. However, additional factors are required to disentangle the relationship between diabetes and cognitive impairment.

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2020

The Canadian Alliance for Healthy Hearts and Minds: How well does it reflect the Canadian population?

Authors: Ruth E. Hall, Natasa Tusevljak, C. Fangyun Wu, Quazi Ibrahim, Karleen Schulze, Anam M. Khan, Dipika Desai, Philip Awadalla, Philippe Broet, Trevor J.B. Dummer, Jason Hicks, Jean-Claude Tardif, Koon K. Teo, Jennifer Vena, Douglas Lee, Matthias Friedrich, Sonia S. Anand, Jack V. Tu

The representativeness of the Canadian Alliance for Healthy Hearts and Minds (CAHHM-HSR) cohort was evaluated by comparing to region matched respondents of the 2015 Canadian Community Health Survey Rapid Response module (CCHS-RR). CAHHM-HSR participants were older, more often women, more likely Chinese, and had higher education, hypertension, hypercholesterolemia and cardiac testing than the general Canadian population. Despite these differences, the INTERHEART risk score was similar.

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2020

Reduced Cognitive Assessment Scores Among Individuals With Magnetic Resonance Imaging–Detected Vascular Brain Injury

Authors: Sonia S. Anand, Matthias G. Friedrich, Dipika Desai, Karleen M. Schulze, Philip Awadalla, David Busseuil, Trevor J.B. Dummer, Sébastien Jacquemont, Alexander Dick, David Kelton, Anish Kirpalani, Scott A. Lear, Jonathan Leipsic, Michael D. Noseworthy, Louise Parker, Grace Parraga, Paul Poirier, Paula Robson, Jean-Claude Tardif, Koon Teo, Jennifer Vena, Salim Yusuf, Alan R. Moody, Sandra E. Black, Eric E. Smith,

This study investigated if scores on a cognitive screen were lower in individuals with higher cardiovascular risk, and those with covert vascular brain injury. Among a middle-aged community-dwelling population, scores on a cognitive screen were lower in individuals with higher cardiovascular risk factors or MRI vascular brain injury. Much of the population attributable risk of low cognitive scores can be attributed to lower educational attainment, higher cardiovascular risk factors, and MRI vascular brain injury.

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2019

Diet Quality among Cancer Survivors and Participants without Cancer: A Population-Based, Cross-Sectional Study in the Atlantic Partnership for Tomorrow’s Health Project

This study investigated the diet quality of cancer survivors relative to participants without cancer, overall and by cancer site and time from diagnosis. It found that there was considerable room for dietary improvement regardless of cancer status, highlighting the need for dietary interventions, especially among cancer survivors, who are at higher risk for secondary health problems.

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2019

Harmonization of the Health and Risk Factor Questionnaire data of the Canadian Partnership for Tomorrow Project: a descriptive analysis

Authors: Isabel Fortier, Nataliya Dragieva, Matilda Saliba, Camille Craig, Paula J. Robson

This paper describes how data is harmonized the health and risk factor questionnare and provides an overview of information required to use the core data that has been created. The reason for the harmonization is to have a unique data set including data on health and risk factors from over 307000 Canadians.

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2018

Metabolic profiling of adherence to diet, physical activity and body size recommendations for cancer prevention

Authors: Qianqian Gu, John Spinelli, Trevor Dummer, Treena McDonald, Steven Moore, Rachel Murphy

This study examined cross-sectional associations between metabolites and cancer preventive behaviors as well as the relevance to cancer-related pathways among 120 participants with no history of smoking or cancer. Cancer preventive behaviors were associated with complex metabolic signatures, including alterations in pathways known to be involved in cancer pathogenesis.

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2018

Cohort Profile: The British Columbia Generations Project (BCGP)

Authors: Anar Dhalla, Treena E McDonald, Richard P Gallagher, John J Spinelli, Angela R Brooks-Wilson, Tim K Lee, Calvin Lai, Marilyn J Borugian, Ryan R Woods, Nhu D Le, Trevor J B Dummer

29850 people in BC were surveyed between the ages of 35-69. Information such as health and lifestyle, physical measurements, biosamples, and genotyping were done.

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2018

The Canadian Partnership for Tomorrow Project: a pan-Canadian platform for research on chronic disease prevention

Authors: Trevor J.B. Dummer, Philip Awadalla, Catherine Boileau, Camille Craig, Isabel Fortier, Vivek Goel, Jason M.T. Hicks, Sébastien Jacquemont, Bartha Maria Knoppers, Nhu Le, Treena McDonald, John McLaughlin, Anne-Marie Mes-Masson, Anne-Monique Nuyt, Lyle J. Palmer, Louise Parker, Mark Purdue, Paula J. Robson, John J. Spinelli, David Thompson, Jennifer Vena, Ma’n Zawati

In order to understand the risk factors for disease, participants across the study were recruited across 5 provinces. Body samples and physical information was collected from these people. They then harmonized this data. The hope out of this paper was that the samples afford strides in research both nationally nad internationally.

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