Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2022

Lifestyle factors and lung cancer risk among never smokers in the Canadian Partnership for Tomorrow’s Health (CanPath)

Authors: Rachel Murphy, Maryam Darvishian, Jia Qi, Yixian Chen, Quincy Chu, Jennifer Vena, Trevor J B Dummer, Nhu Le, Ellen Sweeney, Vanessa DeClercq, Scott A Grandy, Melanie R Keats, Yunsong Cui, Philip Awadalla, Darren R Brenner, Parveen Bhatti

Data from 950 CanPath participants were analyzed to understand why 15-25% of lung cancers occur in never smokers. Researchers found a link between lung cancer risk, sleep, and fruit and vegetable intake amongst never smokers.

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2022

The BC Generations Project as a Tumor Tissue Resource for Cancer Research

Authors: Umaimah Zanif, Jessica Chu, Jonathan Simkin, Trevor Dummer, Ryan Woods, Eric Belanger, Parveen Bhatti

BCGP is making significant strides in its utility as a high-quality tumor tissue research resource. The BC Cancer Registry recently implemented a text mining solution to allow BCGP to capture pathology reports for 100% of all newly diagnosed BCGP cancer cases!

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2022

Evaluation of Adiposity and Cognitive Function in Adults

Authors: Sonia S. Anand, Matthias G. Friedrich, Douglas S. Lee, Phillip Awadalla, J. P. Després, Dipika Desai, Russell J. de Souza, Trevor Dummer, Grace Parraga, Eric Larose, Scott A. Lear, Koon K. Teo, Paul Poirier, Karleen M. Schulze, Dorota Szczesniak, Jean-Claude Tardif, Jennifer Vena, Katarzyna Zatonska, Salim Yusuf, MBBS, DPhil, 1 and Eric E. Smith, MD, MPH 19 , 20 , 21 , for the Canadian Alliance of Healthy Hearts and Minds (CAHHM) and the Prospective Urban and Rural Epidemiological (PURE) Study Investigators

Researchers sought to undercover the association between adipose tissue (amount and distribution) and cognitive scores. Using data from 9,189 participants, they found that higher visceral adipose tissue and body fat percentage correlated with increased vascular brain injuries and cardiovascular risk factors, as well as lower cognitive scores.

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2022

Patterns and determinants of adherence to colorectal cancer primary and secondary prevention recommendations in the BC Generations Project

Authors: Molly Sweeney-Magee, Carolyn Gotay, Mohammad Ehsanul Karim, Jennifer Telford, Trevor Dummer

Researchers assessed how 26,074 BCGP participants adhere to cancer prevention recommendations. They found that adherence to some behaviours was high, but clusters of poorer adherence were also highlighted. They suggested future work to evaluate targeted interventions to maximize adherence amongst lower socioeconomic status and health groups.

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2021

A large Canadian cohort provides insights into the genetic architecture of human hair colour

Authors: Frida Lona-Durazo, Marla Mendes, Rohit Thakur, Karen Funderburk, Tongwu Zhang, Michael A. Kovacs, Jiyeon Choi, Kevin M. Brown, Esteban J. Parra 

Researchers performed genome-wide association studies and meta-analyses to garner insight on regulatory mechanisms of hair colour variation and pigmentation biology. 12,996 genotyped CanPath participants were included in this study, along with their self-reported natural hair colour. The researchers fine-mapped significant loci throughout the genome, identifying multiple novel causal variants for hair colour.

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2021

Effect of Cognitive Reserve on the Association of Vascular Brain Injury with Cognition: Analysis of the PURE and CAHHM Studies

Authors: Romella Durrani, Matthias G. Friedrich, Karleen M. Schulze, Philip Awadalla, Kumar Balasubramanian, Sandra Black, Philippe Broet, David Busseuil, Dipika Desai, Trevor Dummer, Alexander Dick, Jason Hicks, Thomas Iype, David Kelton, Anish Kirpalani, Scott A. Lear, Jonathon Leipsic, Wei Li, Cheryl R. McCreary, Alan R. Moody, Michael D. Noseworthy, Grace Parraga, Paul Poirier, Sumathy Rangarajan, Dorota Szczesniak, Andrzej Szuba, Jean-Claude Tardif, Koon Teo, MBBCH, Jennifer E. Vena, Katarzyna Zatonska, Anna Zimny, Douglas S. Lee, Salim Yusuf, Sonia S. Anand, Eric E. Smith

This study sought to determine whether cognitive reserve lessens the correlation between brain injury and cognition. The researchers analyzed data from two population-based studies, including the Canadian Alliance for Healthy Hearts and Healthy Minds (CAHHM), comprising CanPath national and regional data. They found that brain injury and cognitive reserve are related to cognition, but higher cognitive reserve does not mitigate the harmful effects of brain injury.

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2021

Examining the etiology of early-onset breast cancer in the Canadian Partnership for Tomorrow’s Health (CanPath)

Authors: Joy Pader, Robert Basmadjian, Dylan O'Sullivan, Nicole Mealey, Yibing Ruan, Christine Friedenreich, Rachel Murphy, Edwin Wang, May Lynn Quan, Darren Brenner

The objective of this study was to investigate relationships between modifiable and non-modifiable risk factors and early-onset breast cancer among the BC Generations Project, Alberta’s Tomorrow Project and Ontario Health Study. In this study, measures of adiposity, pregnancy history, and familial history of breast cancer are important risk factors for early-onset breast cancer.

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2021

Metabolomics and cancer preventive behaviors in the BC Generations Project

Authors: J. Qi, J. J. Spinelli, T. J. B. Dummer, P. Bhatti, M. C. Playdon, J. Olin Levitt, B. Hauner, S. C. Moore & R. A. Murphy

To better understand links between behaviours and cancer, researchers measured metabolites in blood samples from 1,319 BC Generations Project participants. The study found a large number of metabolites were different between health behaviours. Highlights include lower levels of metabolites that are involved in pathways that play a role in cancer development among participants who consumed more fruits and vegetables and had a healthy body weight.

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2021

A Prospective Analysis of Plasma Phospholipid Fatty Acids and Breast Cancer Risk in 2 Provinces in Canada

Authors: Marnie Newell, Sunita Ghosh, Susan Goruk, Mohammedreza Pakseresht, Jennifer Vena, Trevor Dummer, Catherine Field

This study compared participants from BCGP and ATP and examined whether there was an association between fatty acid status and the risk of breast cancer, including location, menopausal status, and waist-to-hip ratio as key variables. Findings suggest that regional variations in fatty acid status influence breast cancer risk and highlights the complexity and difficulty in using fatty acid status to predict breast cancer risk in diverse populations without the consideration of other risk factors.

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2021

Normal sex and age-specific parameters in a multi-ethnic population: a cardiovascular magnetic resonance study of the Canadian Alliance for Healthy Hearts and Minds cohort

Authors: Judy M. Luu, Catherine Gebhard, Chinthanie Ramasundarahettige, Dipika Desai, Karleen Schulze, Francois Marcotte, Philip Awadalla, Philippe Broet, Trevor Dummer, Jason Hicks, Eric Larose, Alan Moody, Eric E. Smith, Jean-Claude Tardif, Tiago Teixeira, Koon K. Teo, Jennifer Vena, Douglas S. Lee, Sonia S. Anand, Matthias G. Friedrich

Researchers sought to create a robust, reference value set for cardiovascular magnetic resonance (CMR) parameters, and understand their relationship with age and sex in people without cardiovascular disease (CVD) history or risk factors. They were able to uncover a significant influence of sex and age on these parameters for use in clinical evaluations of CVD.

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