Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2020

Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure

Authors: Florence Lamarche, Mohsen Agharazii, François Madore, Rémi Goupil

This study assessed which of central or brachial blood pressure best predicts cardiovascular risk and identified the central SBP threshold associated with increased risk of future cardiovascular events. It was concluded that central BP measured with a type I device is statistically but likely not clinically superior to brachial BP in a general population without prior cardiovascular disease.

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2020

Job strain and the incidence of heart diseases: A prospective community study in Quebec, Canada

Authors: Niamh Power, Soyna Deschenes, Floriana Ferri, Norbert Schmitz

CARTaGENE survey data linked with administrative data and Cox regression models were used to examine the association between job strain and heart disease, adjusting for sociodemographic characteristics, behavioral and clinical factors, and depressive symptoms. It was found that job strain was associated with an increased risk of heart disease in middle-aged women and in men aged 50 years and older. This association was not accounted for by depressive symptoms or sociodemographic, clinical, and behavioral factors.

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2020

Diabetes, Brain Infarcts, Cognition and Small Vessels in the Canadian Alliance for Healthy Hearts and Minds Study

Authors: Hertzel Gerstein, Eric Smith, Chinthanie Ramasundarahettige, Dipika Desai, Philip Awadalla, Philippe Broet, Sandra Black, Trevor Dummer, Jason Hicks, Alan Moody, Jean-Claude Tardif, Koon Teo, Jennifer Vena, Salim Yusuf, Douglas Lee, Matthias Friedrich, Sonia Anand

The CAHHM study collected brain and carotid magnetic resonance imaging (MRI) and two cognitive tests (DSST and MoCA) in a cross-sectional sample of 7,733 men and women. It was concluded that small vessel disease characterizes much of the relationship between diabetes and vascular brain injury. However, additional factors are required to disentangle the relationship between diabetes and cognitive impairment.

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2020

Diet Quality and Food Prices Modify Associations between Genetic Susceptibility to Obesity and Adiposity Outcomes

Authors: Hannah Yang Han, Catherine Paquet, Laurette Dubé, Daiva E Nielsen

This cross-sectional investigation geo-temporally linked CARTaGENE data with in-store retail food environment data to examine interactions between a polygenic risk score (PRS) for obesity and (1) diet quality (n = 6807) and (2) in-store retail food measures (n = 3718). The outcomes included adiposity-related measures and diet quality assessed using the 2010 Canadian-adapted Healthy Eating Index.

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2020

Sunlight exposure, sun‐protective behaviour, and anti‐citrullinated protein antibody positivity: A general population‐based study in Quebec, Canada

Authors: Naizhou Zhao, Audrey Smargiassi, Ines Colmegna, Marie Hudson, Marvin Fritzer, Sasha Bernatsky

This study examined associations between sunlight exposure and anti-citrullinated protein antibodies (ACPA) using general population data in Quebec. The research team studied 7600 people and did not find conclusive associations, but robust positive relationships were observed between industrial PM2.5 emissions and ACPA.

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2020

The Canadian Alliance for Healthy Hearts and Minds: How well does it reflect the Canadian population?

Authors: Ruth E. Hall, Natasa Tusevljak, C. Fangyun Wu, Quazi Ibrahim, Karleen Schulze, Anam M. Khan, Dipika Desai, Philip Awadalla, Philippe Broet, Trevor J.B. Dummer, Jason Hicks, Jean-Claude Tardif, Koon K. Teo, Jennifer Vena, Douglas Lee, Matthias Friedrich, Sonia S. Anand, Jack V. Tu

The representativeness of the Canadian Alliance for Healthy Hearts and Minds (CAHHM-HSR) cohort was evaluated by comparing to region matched respondents of the 2015 Canadian Community Health Survey Rapid Response module (CCHS-RR). CAHHM-HSR participants were older, more often women, more likely Chinese, and had higher education, hypertension, hypercholesterolemia and cardiac testing than the general Canadian population. Despite these differences, the INTERHEART risk score was similar.

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2020

Long-term exposure to a mixture of industrial SO 2, NO 2, and PM 2.5 and anti-citrullinated protein antibody positivity

Authors: Naizhou Zhao, Audrey Smagiassi, Marianne Hatzopoulou, Ines Colmegna, Marie Hudson, Marvin Fritzler, Philip Awadalla, Sasha Bernatsky

The research team looked at exposures to SO2, NO2, and fine particles matter on anti-citrullinated protein antibodies, a characteristic biomarker for rheumatoid arthritis (RA). It was found that there was a positive correlation between ACPA and industrial emissions of PM2.5 and SO2.

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2020

Association between depressive symptoms, metabolic risk factors, and cognitive function: cross-sectional results from a community study in Quebec, Canada

Authors: Floriana Ferri, Sonya Deschenes, Niamh Power, Nobert Schmitz

This study investigated the cross-sectional association between depressive symptoms and metabolic risk factors with cognitive function in a middle-aged population. They found that comorbidity of depressive symptoms and MetD was associated with reduced cognitive performance in middle-aged adults without diabetes.

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2020

The association between job strain, depressive symptoms, and cardiovascular disease risk: results from a cross-sectional population-based study in Québec, Canada

Authors: Niamh Power, Sonya Deschenes, Floriana, Norbert Schmitz

This study investigated whether there is an association between job strain and cardiovascular disease risk score, when depressive symptoms are controlled for. The results suggest that the job strain is associated with CVD risk score and that this association is not explained by depressive symptoms. Similar associations were observed for males and females.

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2020

Comparison of fracture prediction tools in individuals without and with early chronic kidney disease: A population-based analysis of CARTaGENE

Authors: LC Desbiens, A Sidibe, C Beaudoin, S Jean, F Mac-Way

This study analyzed the CARTaGENE cohort to see how patients with chronic kidney disease were affected by bone fractures.

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