Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2021

Common variants in the CD36 gene are associated with dietary fat intake, high-fat food consumption and serum triglycerides in a cohort of Quebec adults

Authors: Tongzhu Meng, Stan Kubow, Daiva E. Nielsen

This study found that CD36 variants are associated with habitual fat consumption, which may play a role in subsequent associations with chronic-disease biomarkers. Associations differ by BMI status and dietary fat type.

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2021

Predictors of long-term use of prescription opioids in the community-dwelling population of adults without a cancer diagnosis: a retrospective cohort study

Authors: Audrey Béliveau, Anne-Marie Castilloux, Cara Tannenbaum, Philippe Vincent, Cristiano Soares de Moura, Sasha Bernatsky, Yola Moride

This study aimed to identify risk factors for and predictors of long-term use of prescription opioids in the community-dwelling population of adults without a diagnosis of cancer, to inform practice change at the point of care. It was found that limiting the initial supply to no more than 7 days and limiting doses to 90 MME/day or less are actions that could be undertaken at the point of care to prevent long-term use.

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2021

Investigating the causal role of MRE11A p.E506* in breast and ovarian cancer

Authors: Islam Elkholi, Massimo Di Iorio, Somayyeh Fahiminiya, Suzanna Arcand, HyeRim Han, Clara Nogué, Supriya Behl, Nancy Hamel, Sylvie Giroux, Manon de Ladurantaye, Olga Aleynikova, Walter Gotlieb, Jean-François Côté, François Rousseau, Patricia Tonin, Diane Provencher, Anne-Marie MesMasson, Mohammad Akbari, Barbara Rivera, William Foulkes

This study investigated if MRE11A is a true predisposition gene for hereditary breast and ovarian cancer. Investigations suggested that the identified variant is not associated with an increased risk of developing breast or ovarian cancer, and suggests a lack of clinical utility of MRE11A testing in HBOC, at least in the White/Caucasian populations.

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2021

Associations between cognitive function, metabolic factors and depression: A prospective study in Quebec, Canada

Authors: Floriana Ferri, Sonya Dechenes, Niamh Power, Norbert Schmitz

The study used baseline and follow-up CARTaGENE data to assess the potential interactions between low cognitive function, metabolic risk factors and history of depression as risk factors for future depressive episodes. Participants with a comorbidity of at least one metabolic factor, history of depression and low cognitive function were found to have the highest risk of experiencing a depressive episode in middle age.

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2021

Agreement in the CARTaGENE cohort between self-reported medication use and claim data

Authors: Cristiano Moura, Yves Payette, Catherine Boileau, Michal Abrahamowicz, Louise Pilote, Sasha Bernatsky

The research team investigated the agreement of self-reported medication use in CARTaGENE baseline data with provincial health insurance records. Overall, there was a reasonable agreement between the two data sources, but important variations were found for the different drug classes.

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2020

Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure

Authors: Florence Lamarche, Mohsen Agharazii, François Madore, Rémi Goupil

This study assessed which of central or brachial blood pressure best predicts cardiovascular risk and identified the central SBP threshold associated with increased risk of future cardiovascular events. It was concluded that central BP measured with a type I device is statistically but likely not clinically superior to brachial BP in a general population without prior cardiovascular disease.

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2020

Job strain and the incidence of heart diseases: A prospective community study in Quebec, Canada

Authors: Niamh Power, Soyna Deschenes, Floriana Ferri, Norbert Schmitz

CARTaGENE survey data linked with administrative data and Cox regression models were used to examine the association between job strain and heart disease, adjusting for sociodemographic characteristics, behavioral and clinical factors, and depressive symptoms. It was found that job strain was associated with an increased risk of heart disease in middle-aged women and in men aged 50 years and older. This association was not accounted for by depressive symptoms or sociodemographic, clinical, and behavioral factors.

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2020

Diabetes, Brain Infarcts, Cognition and Small Vessels in the Canadian Alliance for Healthy Hearts and Minds Study

Authors: Hertzel Gerstein, Eric Smith, Chinthanie Ramasundarahettige, Dipika Desai, Philip Awadalla, Philippe Broet, Sandra Black, Trevor Dummer, Jason Hicks, Alan Moody, Jean-Claude Tardif, Koon Teo, Jennifer Vena, Salim Yusuf, Douglas Lee, Matthias Friedrich, Sonia Anand

The CAHHM study collected brain and carotid magnetic resonance imaging (MRI) and two cognitive tests (DSST and MoCA) in a cross-sectional sample of 7,733 men and women. It was concluded that small vessel disease characterizes much of the relationship between diabetes and vascular brain injury. However, additional factors are required to disentangle the relationship between diabetes and cognitive impairment.

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2020

Diet Quality and Food Prices Modify Associations between Genetic Susceptibility to Obesity and Adiposity Outcomes

Authors: Hannah Yang Han, Catherine Paquet, Laurette Dubé, Daiva E Nielsen

This cross-sectional investigation geo-temporally linked CARTaGENE data with in-store retail food environment data to examine interactions between a polygenic risk score (PRS) for obesity and (1) diet quality (n = 6807) and (2) in-store retail food measures (n = 3718). The outcomes included adiposity-related measures and diet quality assessed using the 2010 Canadian-adapted Healthy Eating Index.

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2020

Sunlight exposure, sun‐protective behaviour, and anti‐citrullinated protein antibody positivity: A general population‐based study in Quebec, Canada

Authors: Naizhou Zhao, Audrey Smargiassi, Ines Colmegna, Marie Hudson, Marvin Fritzer, Sasha Bernatsky

This study examined associations between sunlight exposure and anti-citrullinated protein antibodies (ACPA) using general population data in Quebec. The research team studied 7600 people and did not find conclusive associations, but robust positive relationships were observed between industrial PM2.5 emissions and ACPA.

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