Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2021

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Authors: Urmo Võsa, Annique Claringbould, Lude Franke, et al.

To investigate the genetics of gene expression, the team performed cis- and trans-expression quantitative trait locus (eQTL) analyses using blood-derived expression from 31,684 individuals through the eQTLGen Consortium.

Read Publication
2021

Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Authors: Lonneke van Tuijl, Adri Voogd, Alexander de Graeff, Adriaan Hoogendoorn, Adelita Ranchor, Kuan-Yu Pan, Maartje Basten, Femke Lamers, Mirjam Geerlings, Jessica Abell, Philip Awadalla, Marije Bakker, Aartjan Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Melanie Keats, Almar Kok, Annemarie Luik, Nolwenn Noisel, N. Charlotte Onland-Moret, Yves Payette, Brenda Penninx, Lützen Portengen, Ina Rissanen, Annelieke Roest, Judith Rosmalen, Rikje Ruiter, Robert Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik Sund, Ellen Sweeney, Alison Teyhan, Ilonca Vaartjes, Kimberly van der Willik, Flora van Leeuwen, Rutger van Petersen, Monique Verschuren, Frank Visseren, Roel Vermeulen, Joost Dekker

This study aims (1) to test whether psychosocial factors are associated with the incidence of any cancer; (2) to test the interaction between psychosocial factors and factors related to cancer risk with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors in the relationship between psychosocial factors and the incidence of cancer.

Read Publication
2021

Epidemiological characteristics of the COVID-19 spring outbreak in Quebec, Canada: a population-based study

Authors: Rodolphe Jantzen, Nolwenn Noisel, Sophie Camilleri-Broet, Catherine Labbe, Thibault de Malliard, Yves Payette, Philippe Broet

This study examined the epidemiological and socio-economic impact of the spring 2020 outbreak of COVID-19 on the Quebec population. An online survey of the participants of CARTaGENE was conducted, with 8,129 respondents. The study found some discrepancies between the symptoms associated with being tested and being positive. The results also emphasize the need for increasing the accessibility of testing for the general population.

Read Publication
2021

Validation of breast cancer risk assessment tools on a French-Canadian population-based cohort

Authors: Rodolphe Jantzen, Yves Payette, Thibault de Malliard, Catherine Labbe, Nolwenn Noisel, Philippe Broet

This study evaluated the use of the Breast Cancer Risk Assessment Tool (BCRAT), International Breast Cancer Intervention Study risk evaluation tool (IBIS), Polygenic Risk Scores (PRS) and combined scores to predict the occurrence of invasive breast cancers at 5 years in a French-Canadian population.

Read Publication
2021

Common variants in the CD36 gene are associated with dietary fat intake, high-fat food consumption and serum triglycerides in a cohort of Quebec adults

Authors: Tongzhu Meng, Stan Kubow, Daiva E. Nielsen

This study found that CD36 variants are associated with habitual fat consumption, which may play a role in subsequent associations with chronic-disease biomarkers. Associations differ by BMI status and dietary fat type.

Read Publication
2021

Predictors of long-term use of prescription opioids in the community-dwelling population of adults without a cancer diagnosis: a retrospective cohort study

Authors: Audrey Béliveau, Anne-Marie Castilloux, Cara Tannenbaum, Philippe Vincent, Cristiano Soares de Moura, Sasha Bernatsky, Yola Moride

This study aimed to identify risk factors for and predictors of long-term use of prescription opioids in the community-dwelling population of adults without a diagnosis of cancer, to inform practice change at the point of care. It was found that limiting the initial supply to no more than 7 days and limiting doses to 90 MME/day or less are actions that could be undertaken at the point of care to prevent long-term use.

Read Publication
2021

Investigating the causal role of MRE11A p.E506* in breast and ovarian cancer

Authors: Islam Elkholi, Massimo Di Iorio, Somayyeh Fahiminiya, Suzanna Arcand, HyeRim Han, Clara Nogué, Supriya Behl, Nancy Hamel, Sylvie Giroux, Manon de Ladurantaye, Olga Aleynikova, Walter Gotlieb, Jean-François Côté, François Rousseau, Patricia Tonin, Diane Provencher, Anne-Marie MesMasson, Mohammad Akbari, Barbara Rivera, William Foulkes

This study investigated if MRE11A is a true predisposition gene for hereditary breast and ovarian cancer. Investigations suggested that the identified variant is not associated with an increased risk of developing breast or ovarian cancer, and suggests a lack of clinical utility of MRE11A testing in HBOC, at least in the White/Caucasian populations.

Read Publication
2021

Associations between cognitive function, metabolic factors and depression: A prospective study in Quebec, Canada

Authors: Floriana Ferri, Sonya Dechenes, Niamh Power, Norbert Schmitz

The study used baseline and follow-up CARTaGENE data to assess the potential interactions between low cognitive function, metabolic risk factors and history of depression as risk factors for future depressive episodes. Participants with a comorbidity of at least one metabolic factor, history of depression and low cognitive function were found to have the highest risk of experiencing a depressive episode in middle age.

Read Publication
2021

Agreement in the CARTaGENE cohort between self-reported medication use and claim data

Authors: Cristiano Moura, Yves Payette, Catherine Boileau, Michal Abrahamowicz, Louise Pilote, Sasha Bernatsky

The research team investigated the agreement of self-reported medication use in CARTaGENE baseline data with provincial health insurance records. Overall, there was a reasonable agreement between the two data sources, but important variations were found for the different drug classes.

Read Publication
2020

Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure

Authors: Florence Lamarche, Mohsen Agharazii, François Madore, Rémi Goupil

This study assessed which of central or brachial blood pressure best predicts cardiovascular risk and identified the central SBP threshold associated with increased risk of future cardiovascular events. It was concluded that central BP measured with a type I device is statistically but likely not clinically superior to brachial BP in a general population without prior cardiovascular disease.

Read Publication