Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses
This study aims (1) to test whether psychosocial factors are associated with the incidence of any cancer; (2) to test the interaction between psychosocial factors and factors related to cancer risk with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors in the relationship between psychosocial factors and the incidence of cancer.
Examining the etiology of early-onset breast cancer in the Canadian Partnership for Tomorrow’s Health (CanPath)
The objective of this study was to investigate relationships between modifiable and non-modifiable risk factors and early-onset breast cancer among the BC Generations Project, Alberta’s Tomorrow Project and Ontario Health Study. In this study, measures of adiposity, pregnancy history, and familial history of breast cancer are important risk factors for early-onset breast cancer.
Diabetes, Brain Infarcts, Cognition and Small Vessels in the Canadian Alliance for Healthy Hearts and Minds Study
The CAHHM study collected brain and carotid magnetic resonance imaging (MRI) and two cognitive tests (DSST and MoCA) in a cross-sectional sample of 7,733 men and women. It was concluded that small vessel disease characterizes much of the relationship between diabetes and vascular brain injury. However, additional factors are required to disentangle the relationship between diabetes and cognitive impairment.
The Canadian Alliance for Healthy Hearts and Minds: How well does it reflect the Canadian population?
The representativeness of the Canadian Alliance for Healthy Hearts and Minds (CAHHM-HSR) cohort was evaluated by comparing to region matched respondents of the 2015 Canadian Community Health Survey Rapid Response module (CCHS-RR). CAHHM-HSR participants were older, more often women, more likely Chinese, and had higher education, hypertension, hypercholesterolemia and cardiac testing than the general Canadian population. Despite these differences, the INTERHEART risk score was similar.
Reduced Cognitive Assessment Scores Among Individuals With Magnetic Resonance Imaging–Detected Vascular Brain Injury
This study investigated if scores on a cognitive screen were lower in individuals with higher cardiovascular risk, and those with covert vascular brain injury. Among a middle-aged community-dwelling population, scores on a cognitive screen were lower in individuals with higher cardiovascular risk factors or MRI vascular brain injury. Much of the population attributable risk of low cognitive scores can be attributed to lower educational attainment, higher cardiovascular risk factors, and MRI vascular brain injury.
Harmonization of the Health and Risk Factor Questionnaire data of the Canadian Partnership for Tomorrow Project: a descriptive analysis
This paper describes how data is harmonized the health and risk factor questionnare and provides an overview of information required to use the core data that has been created. The reason for the harmonization is to have a unique data set including data on health and risk factors from over 307000 Canadians.
The National Cancer Institute Cohort Consortium: An International Pooling Collaboration of 58 Cohorts from 20 Countries
The NCI Cohort Consortium was founded in 2001 and brings together 58 cancer epidemiology cohorts from 20 countries to undertake large-scale pooling research. This article outlines the structure, governance, methods of working, and the participating cohorts (including CanPath), publications and activities of the consortium.
The Canadian Partnership for Tomorrow Project: a pan-Canadian platform for research on chronic disease prevention
In order to understand the risk factors for disease, participants across the study were recruited across 5 provinces. Body samples and physical information was collected from these people. They then harmonized this data. The hope out of this paper was that the samples afford strides in research both nationally nad internationally.
The author who wasn’t there? Fairness and attribution in publications following access to population biobanks
This study conducted a document analysis that looked at publication ethics and authorship with population biobanks. In their findings, they reported a 3-step approach: 1) the biobank should be given proper acknowledgement 2) co-authorship should be encouraged to foster colloboration amongst researchers 3) referencing/citiations should be readily available
Atopic dermatitis and risk of hypertension, type 2 diabetes, myocardial infarction and stroke in a cross‐sectional analysis from the Canadian Partnership for Tomorrow Project
This study wanted to determine if there was an association with atopic dermatitis and hypertension/heart attack/stroke/type II diabetes. It was found in a cross-sectional study that AD is not really a major risk factor for cardiovascular disease.