Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2020

The association between physical activity and self-rated health in Atlantic Canadians

The population of Atlantic Canada is aging rapidly and has among the highest rates of chronic disease in the country. This cross-sectional study drew data from Atlantic PATH to investigate the association between physical activity and self-rated health among adults in this population. The results suggest that physical activity may help to improve perceived health status of individuals with one or more chronic conditions. The findings support literature suggesting that physical activity can be beneficial for adults as they age with chronic disease.

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2019

Diet Quality among Cancer Survivors and Participants without Cancer: A Population-Based, Cross-Sectional Study in the Atlantic Partnership for Tomorrow’s Health Project

This study investigated the diet quality of cancer survivors relative to participants without cancer, overall and by cancer site and time from diagnosis. It found that there was considerable room for dietary improvement regardless of cancer status, highlighting the need for dietary interventions, especially among cancer survivors, who are at higher risk for secondary health problems.

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2019

Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing

Authors: Xiaojian Shao, Marie Hudson, Ines Colmegna, Celia Greenwood, Marvin Fritzler, Philip Awadalla, Tomi Pastinen, Sasha Bernatsky

They wanted to compare DNA methylation in subjects postivie/negative for anti-citrullinated protein antibodies which is a key marker for rheumatoid arthritis. They measured the DNA methylation of 137 subjects, 63 who were ACPA-positive, 66 were negative and 8 were self-reported with their rheumatoid arthritis.

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2019

Green space associations with mental health and cognitive function

Authors: Perry Hystad, Yves Payette, Nolwenn Noisel, Catherine Bolieau

This study was done so that they could determine the relationship between mental health and access to green space. They enrolled 8144 people and used questionnares to measure any depression/anxiety. They found that while urban green space affords a lower depression score, it does not affect cognitive function.

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2019

Nuclear genetic regulation of the human mitochondrial transcriptome

Authors: Aminah Ali, Lena Boehme, Guillermo Carbajosa, Vlad Seitan, Kerrin Small, Alan Hodgkinson

They analyzed more than 11000 RNA sequencing libraries across 36 tissue/cell types and they found considerable variation in mitochondrial gene expression along the transcriptome. This was also looked at tissues and inviduals and highlighted the importance of cell-type specific and post transcriptional processes in shaping mitochondrial-encoded RNA levels.

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2019

Fracture status in middle-aged individuals with early CKD: cross-sectional analysis of the CARTaGENE survey

Authors: L.C. Desbiens, R. Goupil., A. Sidine., F. Madore., F. Mac-Way

In this cross-sectional analysis, the study team determined that CKD was not correlated with increase fractures, was not a modification factor between calcaneal QUS and fracture, but modified the association between clinical, pharmacological parameters and fracture.

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2019

Identifying Rheumatoid Arthritis Cases within the Quebec Health Administrative Database

Authors: Zeinab Slim, Cristiano Moura, Sasha Bernatsky, Elham Rahme

The team’s objective was to calculate rheumatoid arthritis point prevalence in the CARTaGENE cohort. They also aimed to estimate sensitivity/specificity. In the study, they were looking at 3 factors: number of years of billing data, addition of self reported information of RA diagnosis and drugs, and adjustment for calculation error. They found that there was a RAMQ sensitivity of 84% and specificity of 99.8%. Their results showed variations in the prevalence point estimates of the 3 factors being assessed.

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2019

Care quality for rheumatoid arthritis patients in Quebec

Authors: Zeinab Slim, Cristiano Moura, Sasha Bernatsky, Elham Rahme

The main objectives of this study were to determine the number of CARTaGENE participants with rheumatoid arthritis that fulfilled pre-specified quality indicators and to examine the variation in DMARD use with respect to patient age,sex, education, and income. They assessed ~20000 people, and 142 rheumatoid arthritis patients. Quality Indicators that pertained to RA pharmacotheraphy and medical treatment ranged from 60-80%,. With lifestyle factors, 55% had moderate physical activity and less than 17% were reported to be smokers.

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2019

Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians

Authors: Florian Wunnemann, Ken Sin Lo, Alexandra Langford-Avelar, David Busseuil, Marie-Pierre Dube, Jean-Claude Tardiff, Guillaume Lettre

This article looked at ways of predicting/preventing coronary artery disease. Polygenic risk scores based on the genome sequence can be a potential biomarker to predict the risk of CAD. Validation of PRS predictive power and transferability in other populations can support clinical utility.

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2019

The Establishment of the Household Air Pollution Consortium (HAPCO)

Authors: H. Dean Hosgood, Madelyn Klugman, Keitaro Matuso, Alexandra White, Atusko Sadakane, Xiao-Ou Shu, Ruy Lopez-Ridaura, Aesun Shin, Ichiro Tsuji, Reza Malekzadeh, Nolwenn Noisel, Parveen Bhatti, Gong Yang, Eiko Saito, Shaifuir Rahman, Wei hu, Bryan Bassig, George Downward, Roel Vemeulen, Xiaonan Xue, Thomas Rohan, Sarah Abe, Philippe Broet, Eric Grant, Trevor Dummer, Nat Rothman, Manami Inoue, Martin Lajouis, Keun-Young Yoo, Hidemi Ito, Dale Sandler, Habib Ashan, Wei Zheung, Paolo Boffetta, Qing Lan

This article looked at some of the dangers surrounding household air pollution and and it’s association with lung cancer. The Household Air Pollution Consortium will make sure that there is research being done to address public health concerns associated with HAP.

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