An examination of the role of socioeconomic status in the relationship between depression and prostate cancer survivorship in a population-based sample of men from Atlantic Canada
This study found that the association of depression and prostate cancer still stands when the survivors of prostate cancer are compared to survivors of any other form of cancer, and further indicates that the association is moderated by household income.
Common variants in the CD36 gene are associated with dietary fat intake, high-fat food consumption and serum triglycerides in a cohort of Quebec adults
This study found that CD36 variants are associated with habitual fat consumption, which may play a role in subsequent associations with chronic-disease biomarkers. Associations differ by BMI status and dietary fat type.
Predictors of long-term use of prescription opioids in the community-dwelling population of adults without a cancer diagnosis: a retrospective cohort study
This study aimed to identify risk factors for and predictors of long-term use of prescription opioids in the community-dwelling population of adults without a diagnosis of cancer, to inform practice change at the point of care. It was found that limiting the initial supply to no more than 7 days and limiting doses to 90 MME/day or less are actions that could be undertaken at the point of care to prevent long-term use.
Investigating the causal role of MRE11A p.E506* in breast and ovarian cancer
This study investigated if MRE11A is a true predisposition gene for hereditary breast and ovarian cancer. Investigations suggested that the identified variant is not associated with an increased risk of developing breast or ovarian cancer, and suggests a lack of clinical utility of MRE11A testing in HBOC, at least in the White/Caucasian populations.
Regional Comparisons of Associations between Physical Activity Levels and Cardiovascular Disease: The Story of Atlantic Canada
The study examined participants’ physical activity levels and the risk of cardiovascular disease based on the region they lived in. The research team found that high physical activity was associated with a 26% reduced risk of cardiovascular disease. Regions in Newfoundland and New Brunswick observed higher levels of CVD than Nova Scotia and PEI.
Associations between cognitive function, metabolic factors and depression: A prospective study in Quebec, Canada
The study used baseline and follow-up CARTaGENE data to assess the potential interactions between low cognitive function, metabolic risk factors and history of depression as risk factors for future depressive episodes. Participants with a comorbidity of at least one metabolic factor, history of depression and low cognitive function were found to have the highest risk of experiencing a depressive episode in middle age.
Agreement in the CARTaGENE cohort between self-reported medication use and claim data
The research team investigated the agreement of self-reported medication use in CARTaGENE baseline data with provincial health insurance records. Overall, there was a reasonable agreement between the two data sources, but important variations were found for the different drug classes.
Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure
This study assessed which of central or brachial blood pressure best predicts cardiovascular risk and identified the central SBP threshold associated with increased risk of future cardiovascular events. It was concluded that central BP measured with a type I device is statistically but likely not clinically superior to brachial BP in a general population without prior cardiovascular disease.
Job strain and the incidence of heart diseases: A prospective community study in Quebec, Canada
CARTaGENE survey data linked with administrative data and Cox regression models were used to examine the association between job strain and heart disease, adjusting for sociodemographic characteristics, behavioral and clinical factors, and depressive symptoms. It was found that job strain was associated with an increased risk of heart disease in middle-aged women and in men aged 50 years and older. This association was not accounted for by depressive symptoms or sociodemographic, clinical, and behavioral factors.
Associations between Neighborhood Walkability, Physical Activity, and Chronic Disease in Nova Scotian Adults: An Atlantic PATH Cohort Study
The study investigated the association between neighbourhood walkability and chronic disease. A cross-sectional study was used to determine that there were health protective benefits of higher levels of physical activity and a reduction in the prevalence of certain chronic diseases in areas where there was a higher walk score.