Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2021

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Authors: Urmo Võsa, Annique Claringbould, Lude Franke, et al.

To investigate the genetics of gene expression, the team performed cis- and trans-expression quantitative trait locus (eQTL) analyses using blood-derived expression from 31,684 individuals through the eQTLGen Consortium.

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2021

Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Authors: Lonneke van Tuijl, Adri Voogd, Alexander de Graeff, Adriaan Hoogendoorn, Adelita Ranchor, Kuan-Yu Pan, Maartje Basten, Femke Lamers, Mirjam Geerlings, Jessica Abell, Philip Awadalla, Marije Bakker, Aartjan Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Melanie Keats, Almar Kok, Annemarie Luik, Nolwenn Noisel, N. Charlotte Onland-Moret, Yves Payette, Brenda Penninx, Lützen Portengen, Ina Rissanen, Annelieke Roest, Judith Rosmalen, Rikje Ruiter, Robert Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik Sund, Ellen Sweeney, Alison Teyhan, Ilonca Vaartjes, Kimberly van der Willik, Flora van Leeuwen, Rutger van Petersen, Monique Verschuren, Frank Visseren, Roel Vermeulen, Joost Dekker

This study aims (1) to test whether psychosocial factors are associated with the incidence of any cancer; (2) to test the interaction between psychosocial factors and factors related to cancer risk with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors in the relationship between psychosocial factors and the incidence of cancer.

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2021

Post-Treatment Adverse Health Correlates among Prostate Cancer Survivors in a Sample of Men Residing in Atlantic Canada

Authors: Gabriela Ilie, Robert Rutledge, Ellen Sweeney

A cross-sectional analysis was conducted on a subsample of 632 male participants aged 36–69 the Atlantic PATH. The primary outcomes were the presence of mild, moderate or severe depression or anxiety indicators and were assessed using the seven-item generalized anxiety disorder (GAD-7) scale and the nine-item Patient Health Questionnaire (PHQ-9), respectively.

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2021

Environmental Correlates of Physical Activity, Sedentary Behavior, and Self-Rated Health in Chronic Obstructive Pulmonary Disease

Authors: Daniel Stevens, Pantelis Andreou, Daniel Rainham

This study sought to investigate associations between the environment and physical activity, sedentary behavior, and self-rated health in Chronic Obstructive Pulmonary Disease. The new data may identify barriers to physical activity and assist clinicians in the prescription of exercise for individuals living with COPD.

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2021

Age and Sex-Specific Associations in Health Risk Factors for Chronic Disease: Evidence from the Atlantic Partnership for Tomorrow’s Health (PATH) Cohort

Authors: Vanessa DeClerq, Ellen Sweeney

The objective of this study was to discern health risk factors for chronic disease by age and sex using health risk factor data from participants of the Atlantic PATH (n = 16,165). The study found evident differences in health risk factors for males and females, as well as across age groups.

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2021

Examining the etiology of early-onset breast cancer in the Canadian Partnership for Tomorrow’s Health (CanPath)

Authors: Joy Pader, Robert Basmadjian, Dylan O'Sullivan, Nicole Mealey, Yibing Ruan, Christine Friedenreich, Rachel Murphy, Edwin Wang, May Lynn Quan, Darren Brenner

The objective of this study was to investigate relationships between modifiable and non-modifiable risk factors and early-onset breast cancer among the BC Generations Project, Alberta’s Tomorrow Project and Ontario Health Study. In this study, measures of adiposity, pregnancy history, and familial history of breast cancer are important risk factors for early-onset breast cancer.

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2021

Dietary patterns with combined and site-specific cancer incidence in Alberta’s Tomorrow Project cohort

Authors: Romy Willemsen, Jessica McNeil, Emily Heer, Steven Johnson, Christine Fredenreich, Darren Brenner

This study used data from the Alberta’s Tomorrow Project to examine the association between dietary patterns derived with two methods, and combined and site-specific cancer incidence in Canada.

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2021

The association between mental health and shift work: Findings from the Atlantic PATH study

Authors: Ellen Sweeney, Yunsong Cui, Zhijie Michael Yu, Trevor Dummer, Vanessa DeClercq, Cynthia Forbes, Scott Grandy, Melanie Keats, Anil Adisesh

This study found that shift workers reported higher levels of anxiety, depression, and lower self-rated health than non-shift workers. Shift workers were more likely to report major depression and poor self-rated health, and female shift workers were more likely to report depressive symptoms and poor self-rated health.

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2021

Epidemiological characteristics of the COVID-19 spring outbreak in Quebec, Canada: a population-based study

Authors: Rodolphe Jantzen, Nolwenn Noisel, Sophie Camilleri-Broet, Catherine Labbe, Thibault de Malliard, Yves Payette, Philippe Broet

This study examined the epidemiological and socio-economic impact of the spring 2020 outbreak of COVID-19 on the Quebec population. An online survey of the participants of CARTaGENE was conducted, with 8,129 respondents. The study found some discrepancies between the symptoms associated with being tested and being positive. The results also emphasize the need for increasing the accessibility of testing for the general population.

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2021

The effect of different methods to identify, and scenarios used to address energy intake misestimation on dietary patterns derived by cluster analysis

Authors: Geraldine Lo Siou, Alianu Akawung, Nathan Solbak, Kathryn McDonald, Ala Al Rajabi, Heather Whelan, Sharon Kirkpatrick

This study used self-reported food frequency and physical activity data from Alberta’s Tomorrow Project participants to compare the revised-Goldberg and the predicted total energy expenditure methods in their ability to identify misreporters of energy intake.

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