Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2020

The Canadian Alliance for Healthy Hearts and Minds: How well does it reflect the Canadian population?

Authors: Ruth E. Hall, Natasa Tusevljak, C. Fangyun Wu, Quazi Ibrahim, Karleen Schulze, Anam M. Khan, Dipika Desai, Philip Awadalla, Philippe Broet, Trevor J.B. Dummer, Jason Hicks, Jean-Claude Tardif, Koon K. Teo, Jennifer Vena, Douglas Lee, Matthias Friedrich, Sonia S. Anand, Jack V. Tu

The representativeness of the Canadian Alliance for Healthy Hearts and Minds (CAHHM-HSR) cohort was evaluated by comparing to region matched respondents of the 2015 Canadian Community Health Survey Rapid Response module (CCHS-RR). CAHHM-HSR participants were older, more often women, more likely Chinese, and had higher education, hypertension, hypercholesterolemia and cardiac testing than the general Canadian population. Despite these differences, the INTERHEART risk score was similar.

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2020

Portable X-ray Fluorescence of Zinc Applied to Human Toenail Clippings

Authors: David E.B.Fleming, Samantha L. Crook, Colby T. Evans, Michel N. Nader, Manuel Atia, Jason M. T. Hicks, Ellen Sweeney, Christopher R. McFarlane, Jong Sung Kim, Erin Keltie, Anil Adisesh

The purpose of this study was to see if it was feasible to measure the zinc levels in the fingernails of people. They used an x-ray fluorescence to measure how much zinc was present in the nails. It was found that the latter was very sensitive at detecting zinc in the nail and would be able to measure fluctuating levels of zinc as time went on.

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2020

Burden of multimorbidity and polypharmacy among cancer survivors: a population-based nested case–control study

Authors: Melanie Keats, Yunsong Cui, Vanessa DeClerq, Scott Grandy, Ellen Sweeney, Trevor Dummer

The purpose of this study was to investigate if adult cancer survivors showed more than one comorbidity while taking medications. The article found multimorbities in 53% of cancer survivors. Those on multiple medications showed much higher results.

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2020

Long-term exposure to a mixture of industrial SO 2, NO 2, and PM 2.5 and anti-citrullinated protein antibody positivity

Authors: Naizhou Zhao, Audrey Smagiassi, Marianne Hatzopoulou, Ines Colmegna, Marie Hudson, Marvin Fritzler, Philip Awadalla, Sasha Bernatsky

The research team looked at exposures to SO2, NO2, and fine particles matter on anti-citrullinated protein antibodies, a characteristic biomarker for rheumatoid arthritis (RA). It was found that there was a positive correlation between ACPA and industrial emissions of PM2.5 and SO2.

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2020

Association between lifestyle behaviors and frailty in Atlantic Canadian males and females

Authors: Vanessa DeClerq, Todd Duhamel, Olga Teou, Scott Kehler

The aim of this study was to identify lifestyle factors in males and females that are associated with a degree of frailty in a Canadian cohort. Higher frailty was more prevalent among participants with unhealthy lifestyle behaviors related to smoking, alcohol consumption, sedentary and physical activity level, diet, and sleep.

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2020

Associations between the neighbourhood characteristics and body mass index, waist circumference, and waist-to-hip ratio: Findings from Alberta’s Tomorrow Project

Authors: Vikram Nichani, Liam Turley, Jennifer Vena, Gavin McCormack

This study estimated the associations between neighbourhood characteristics and self-reported body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) risk categories among Canadian men and women.

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2020

The association between job strain, depressive symptoms, and cardiovascular disease risk: results from a cross-sectional population-based study in Québec, Canada

Authors: Niamh Power, Sonya Deschenes, Floriana, Norbert Schmitz

This study investigated whether there is an association between job strain and cardiovascular disease risk score, when depressive symptoms are controlled for. The results suggest that the job strain is associated with CVD risk score and that this association is not explained by depressive symptoms. Similar associations were observed for males and females.

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2020

Comparison of fracture prediction tools in individuals without and with early chronic kidney disease: A population-based analysis of CARTaGENE

Authors: LC Desbiens, A Sidibe, C Beaudoin, S Jean, F Mac-Way

This study analyzed the CARTaGENE cohort to see how patients with chronic kidney disease were affected by bone fractures.

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2020

Quantifying the Predictive Accuracy of a Polygenic Risk Score for Predicting Incident Cancer Cases: Application to the CARTaGENE Cohort

Authors: Julianne Duhaze, Rodolpje Jantzen, Yves Payette, Thibault De Malliard, Catherine Labbe, Nolwenn Noisel, Philippe Broet

This study evaluated the 5-year predictivity of an 18-single nucleotide polymorphism PRS for incident breast cancer cases in the CARTaGENE cohort using pseudo R^2 indices. It concluded that the proposed pseudo-R^2 is easy to implement and well suited to evaluate PRS for predicting incident events in cohort studies.

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2020

Founder BRCA1/BRCA2/PALB2 pathogenic variants in French-Canadian breast cancer cases and controls

Authors: Supriya Behl, Nancy Hamel, Manon de Laduarantaye, Stephanie Lepage, Rejean LaPointe, Anne-Marie Mes-Massson, William Foulkes

The purpose of this study was to evaluate the efficacy of genetic testing for these variants of the BRCA gene in Montreal French Canadians. A total of 555 breast cancer cases unselected for family history or age of diagnosis were genotyped, along with 1940 controls without a personal or family history of cancer. Almost 10% of the early onset cases of BC were heterozygous for founder BRCA1 or BRCA2. 7 of the 20 variants of the breast cancer gene tested for were found in this study.

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