Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2022

Applying Machine Learning to Arsenic Species and Metallomics Profiles of Toenails to Evaluate Associations of Environmental Arsenic with Incident Cancer Cases

Authors: Sheida Majouni, Jong Sung Kim, Ellen Sweeney, Erin Keltie, Syed Sibte Raza Abidi

This preliminary study aimed to understand the association between environmental metal pathogenicity and carcinogenicity and prostate cancer. Researchers used toenails to capture arsenic exposure!

Read Publication
2022

A dietary carbohydrate – gut Parasutterella – human fatty acid biosynthesis metabolic axis in obesity and type 2 diabetes

Authors: Lea Henneke, Kristina Schlicht, Nadia A. Andreani, Tim Hollstein, Tobias Demetrowitsch, Carina Knappe, Katharina Hartmann, Julia Jensen-Kroll, Nathalie Rohmann, Daniela Pohlschneider, Corinna Geisler, Dominik M. Schulte, Ute Settgast, Kathrin Türk, Johannes Zimmermann, Christoph Kaleta, John F. Baines, Jane Shearer, Shrushti Shah, Grace Shen-Tu, Karin Schwarz, Andre Franke, Stefan Schreiber, Matthias Laudes

This study aimed to characterize Parasutterella, a gut bacteria, in a European cohort. 438 participants from Alberta’s Tomorrow Project were included to validate the results of this study. Researchers found that this bacteria have a role in type 2 diabetes and obesity.

Read Publication
2022

Health-Related and Behavioral Factors Associated With Lung Cancer Stage at Diagnosis: Observations From Alberta’s Tomorrow Project

Authors: Michelle L. Aktary, Monica Ghebrial, Qinggang Wang, Lorraine Shack, Paula J. Robson, Karen A. Kopciuk

This study examined sociodemographic characteristics and health-related factors and their associations with subsequent lung cancer stage at diagnosis. Using data from 221 Alberta’s Tomorrow Project participants, researchers found that a history of sunburn in the past year and more prostate-specific antigen tests were protective against late-stage lung cancer diagnosis, whereas physical activity increased late-stage cancer diagnosis odds.

Read Publication
2022

Pre-diagnosis lifestyle, health history and psychosocial factors associated with stage at breast cancer diagnosis – Potential targets to shift stage earlier

Authors: Qinggang Wang, Michelle L. Aktary, John J. Spinelli, Lorraine Shack, Paula J.Robson, Karen A. Kopciuk

This study aimed to examine associations between risk factors for breast cancer diagnosis, prior to and and at diagnosis. Some protective factors include older age at diagnosis, high household income, parity, smoking, spending time in the sun (high ultraviolet), having a mammogram, and high daily protein intake. Factors that increase risk of later stage at diagnosis include comorbidities, stressful situations, and high daily caloric intake.

Read Publication
2022

The association between religiosity, spirituality, and breast cancer screening: A cross-sectional analysis of Alberta’s Tomorrow Project

Authors: Susan Mirabi, Ashok Chaurasia, Mark Oremus

Researchers explored data from 2,569 ATP participants regarding religiosity, spirituality, and breast cancer screening. They found that greater religiosity and spirituality salience were unrelated to mammogram receipt. However, they suggest future research to investigate subgroups of the population and whether religiosity and spirituality may promote screening amongst those with strong pre-existing connections to faith.

Read Publication
2022

Analysis of human serum and urine for tentative identification of potentially carcinogenic pesticide-associated N-nitroso compounds using high-resolution mass spectrometry

Authors: Crystal L. Sweeney, Nathan K. Smith, Ellen Sweeney, Alejandro M. Cohen, Jong Sung Kim

Using data from 64 Atlantic PATH participants, this study marks the first biomonitoring investigation of PANN compounds in human serum and urine. A majority of the participants were found to have been exposed to some nitrosatable pesticides and potentially carcinogenic PANN compounds.

Read Publication
2022

Socio-Demographic Factors Associated With COVID-19 Vaccine Hesitancy Among Middle-Aged Adults During the Quebec’s Vaccination Campaign

Authors: Rodolphe Jantzen, Mathieu Maltais, Philippe Broët

This study aimed to describe how socioeconomic and demographic characteristics affect vaccine hesitancy. Using data from 6,105 CARTaGENE participants, researchers found that those born outside of Canada and those with a household income under $100,000 had the greatest hesitancy.

Read Publication
2022

Lifestyle factors and lung cancer risk among never smokers in the Canadian Partnership for Tomorrow’s Health (CanPath)

Authors: Rachel Murphy, Maryam Darvishian, Jia Qi, Yixian Chen, Quincy Chu, Jennifer Vena, Trevor J B Dummer, Nhu Le, Ellen Sweeney, Vanessa DeClercq, Scott A Grandy, Melanie R Keats, Yunsong Cui, Philip Awadalla, Darren R Brenner, Parveen Bhatti

Data from 950 CanPath participants were analyzed to understand why 15-25% of lung cancers occur in never smokers. Researchers found a link between lung cancer risk, sleep, and fruit and vegetable intake amongst never smokers.

Read Publication
2022

Toenail speciation biomarkers in arsenic-related disease: a feasibility study for investigating the association between arsenic exposure and chronic disease

Authors: Nathan Kyle Smith, Erin Keltie, Ellen Sweeney, Swarna Weerasignhe, Kathleen MacPherson, Jong Sung Kim

With data from 60 Atlantic PATH participants, this study aimed to develop a method to analyze arsenic in toenails, distinguish arsenic speciation profiles in those with chronic diseases, and assess the novel method’s feasibility to find speciation pattern differences between the disease groups. This is the first study to describe arsenic speciation patterns in those with arsenic-related diseases using toenails!

Read Publication
2022

Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin

Authors: Christina B. Joseph, Marta Mariniello, Ayumi Yoshifuji, Guglielmo Schiano, Jennifer Lake, Jonathan Marten, Anne Richmond, Jennifer E. Huffman, Archie Campbell, Sarah E. Harris, Stephan Troyanov, Massimiliano Cocca, Antonietta Robino, Sébastien Thériault, Kai-Uwe Eckardt, Matthias Wuttke, Yurong Cheng, Tanguy Corre, Ivana Kolcic, Corrinda Black, Vanessa Bruat, Maria Pina Concas, Cinzia Sala, Stefanie Aeschbacher, Franz Schaefer, Sven Bergmann, Harry Campbell, Matthias Olden, Ozren Polasek, David J. Porteous, Ian J. Deary, Francois Madore, Philip Awadalla, Giorgia Girotto, Sheila Ulivi, David Conen, Elke Wuehl, Eric Olinger, James F. Wilson, Murielle Bochud, Anna Köttgen, Caroline Hayward, Olivier Devuyst

This study is a meta-analysis of genome-wide association studies to understand the mechanisms that regulate urinary excretion of uromodulin. Researchers identified two novel significant loci, providing insight into uromodulin’s biology, keratins’ role in the kidney, and the UMOD-PDILT locus’s influence on kidney function.

Read Publication