Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2020

Association of Glomerular Hyperfiltration and Cardiovascular Risk in Middle-Aged Healthy Individuals

Authors: Marie-Eve Dupuis, Annie-Claire Nadeau-Fredette, Francois Madore, Mohsen Agarazii, Remi Goupil

In this cohort study of 9,515 patients with health information accessed through the CARTaGENE cohort, glomerular hyperfiltration was shown to be associated with increased risk of cardiovascular events in middle-aged healthy individuals. This suggests that glomerular hyperfiltration could be a useful cardiovascular biomarker in this population.

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2020

Physical Activity is Associated With Reduced Prevalence of Self-Reported Obstructive Sleep Apnea in a Large, General Population Cohort Study

Authors: Kelly Hall, Mandeep Singh, Sutapa Mukherjee, Lyle Palmer

The researchers used Ontario Health Study data to determine if physical activity would reduce the prevalence of OSA. Upon determining the prevalence of OSA, the reseachers were able to do a cross sectional analysis to determine that increased physical activity had a statistical significance of (P ≤ 0.045). Moderate activity did not have much of an impact on the prevalence of OSA. These results showed that increased physical activity would be a preventative measure for OSA.

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2020

Reduced Cognitive Assessment Scores Among Individuals With Magnetic Resonance Imaging–Detected Vascular Brain Injury

Authors: Sonia S. Anand, Matthias G. Friedrich, Dipika Desai, Karleen M. Schulze, Philip Awadalla, David Busseuil, Trevor J.B. Dummer, Sébastien Jacquemont, Alexander Dick, David Kelton, Anish Kirpalani, Scott A. Lear, Jonathan Leipsic, Michael D. Noseworthy, Louise Parker, Grace Parraga, Paul Poirier, Paula Robson, Jean-Claude Tardif, Koon Teo, Jennifer Vena, Salim Yusuf, Alan R. Moody, Sandra E. Black, Eric E. Smith,

This study investigated if scores on a cognitive screen were lower in individuals with higher cardiovascular risk, and those with covert vascular brain injury. Among a middle-aged community-dwelling population, scores on a cognitive screen were lower in individuals with higher cardiovascular risk factors or MRI vascular brain injury. Much of the population attributable risk of low cognitive scores can be attributed to lower educational attainment, higher cardiovascular risk factors, and MRI vascular brain injury.

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2020

Is there an agreement between self-reported medical diagnosis in the CARTaGENE cohort and the Québec administrative health databases?

Authors: Yves Payette, Cristiano Soares de Moura, Catherine Boileau, Sasha Bernatsky, Nolwenn Noisel

This study sought to determine if administrative health data and self-report questionnaires would yield the same information as population health studies. Further the research team hoped to identify statisical predictors. It was determined that there was agreement between AHD and self reported questionnaire and that there were variations depending on the disease.

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2020

The association between physical activity and self-rated health in Atlantic Canadians

The population of Atlantic Canada is aging rapidly and has among the highest rates of chronic disease in the country. This cross-sectional study drew data from Atlantic PATH to investigate the association between physical activity and self-rated health among adults in this population. The results suggest that physical activity may help to improve perceived health status of individuals with one or more chronic conditions. The findings support literature suggesting that physical activity can be beneficial for adults as they age with chronic disease.

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2020

Impact of updated recommendations on acetylsalicylic acid use for primary prevention of cardiovascular disease in Canada: a population-based survey

Authors: Myriam Khalili, Fanny Lepeytre, Jason Guertin, Remi Goupil, Stephan Troyanov, Josee Bouchard, Francois Madore

This study aimed to evaluate the prevalence and factors associated with ASA use, and the potential impact of implementing the most recent (2016) US Preventive Services Task Force recommendations for primary CVD prevention in a Canadian setting.

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2020

Investigating associations between anti-nuclear antibody positivity and combined long-term exposures to NO2, O3, and PM2.5 using a Bayesian kernel machine regression approach.

Authors: Naizhou Zhao, Audrey Smagiassi, Marie Hudson, Marvin Fritzler, Sasha Bernatsky,

This group determined ANA using biobanked sera, they asssesed the effects of exposures to NO2 and O3 and PM2.5, they compared the results obtained by the BKMR to standard logistic regression models

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2020

Incidence of fractures in middle-aged individuals with early chronic kidney disease: a population-based analysis of CARTaGENE

Authors: Louis-Charles Desbiens, Remi Goupil, Francois Madore, Fabrice Mac-Way

This article looked at the the number of new fractures with people in the CARTaGENE cohort that were affected with CKD

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2020

Anxiety and Depression Symptom Comorbidity and the Risk of Heart Disease: A Prospective Community-Based Cohort Study

Authors: SS Descenes, RJ Burns, N Schmitz

This article was looking at the association between anxiety/depression and heart disease. They found depression without anxiety had a higher risk of heart disease. There was no significant risk of heart disease when there was anxiety, but not depression.

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2020

Interaction of DRD2/ANKK1 Taq1A Genotype with in-Store Retail Food Environment Exposures on Diet Quality in a Cohort of Quebec Adults.

Authors: Neilsen, Han, Paquet, Portella, Ma, Dube

DRD2/ANKK1 Taq1A is associated with adaptive responses to ice cream displays and vegetable prices, suggesting a differential susceptibility to retail environment food cues.

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