Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2019

Plasma-Derived Inflammatory Proteins Predict Oral Squamous Cell Carcinoma

Authors: Kelly Vi Ping Liu, Xian Jun David Lu, Yuqi Sarah Zhu, Nhu Le, Hugh Kim, Catherine Poh

This study looked at a multiplex approach to screen plasma derived biomarkers and to examine the association of proteins with throat cancer. They looked at 260 plasma samples and they screened 82 biomarkers to look for disease.

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2019

The Relationship between Anthropometric Measures and Cardiometabolic Health in Shift Work: Findings from the Atlantic PATH Cohort Study

Authors: Ellen Sweeney, Zhijie Yu, Trevor Dummer, Yunsong Cui, Vanessa DeClerq, Cynthia Forbes, Scott Grandy, Melanie Keats, Louise Parker, Anil Adisesh

This article was written to evaluate the relationship between anthropomeric measures and cardiometabolic health in shift workers compared to non-shift workers. They looked at 4155 shift workers and 8258 non-shift workers. There was a slight risk of CVD, obesity, and diabetes among shift workers. It also shown that shift workers were 17% more likely to be obese and 27% more likely to have diabetes.

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2019

Rural‐Urban Disparities in Total Physical Activity, Body Composition, and Related Health Indicators: An Atlantic PATH Study

Authors: Cynthia Forbes, Zhijie Michael Yu, Yunsong Cui, Vanessa DeClerq, Scott Grandy, Louise Parker, Ellen Sweeney, Trevor Dummer, Melanie Keats

This study was done to compare the sociodemographic/lifestyle characteristics of urban/rural residents in Atlantic Canada. Over 17000 adults were surveyed and multi-linear/logistic regression were done. It was found that rural residents were significantly less likely to be regular or habitual drinkers. Obesity prevalence was much higher out in the Atlantic provinces.

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2019

Harmonization of the Health and Risk Factor Questionnaire data of the Canadian Partnership for Tomorrow Project: a descriptive analysis

Authors: Isabel Fortier, Nataliya Dragieva, Matilda Saliba, Camille Craig, Paula J. Robson

This paper describes how data is harmonized the health and risk factor questionnare and provides an overview of information required to use the core data that has been created. The reason for the harmonization is to have a unique data set including data on health and risk factors from over 307000 Canadians.

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2019

Central body fatness is a stronger predictor of cancer risk than overall body size

Authors: Amanda Barberio, Asalah Alareeki, Benjamin Viner, Joy Pader, Jennifer Vena, Paul Arora, Christine Fredenreich, Darren Brenner

They wanted to see the relationship between body size and weight distribution for cancer risk. They had a sample size of 26607 and determined that men have a 33% increased risk of cancer, while women have 22% increased risk. Essentially central adiposity appears to be a strong predictor of all-cancer risk than actual body size.

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2019

Anthropometric changes and risk of diabetes: are there sex differences? A longitudinal study of Alberta’s Tomorrow Project

Authors: Ming Ye, Paula Robson, Dean Eurich, Jennifer Vena, Jian-Yi Xu, Jefferey A Johnson

The objective this was study was see if there was an association with antropometric change and risk of diabetes. There was a positive association between anthropometric changes and risk of diabetes was found more in men than women.

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2019

Uromodulin in a Pathway Between Decreased Renal Urate Excretion and Albuminuria

Authors: Alena Krajcoviechova, Francois-Christophe Marois-Blanchet, Stephan Troyanov, Francois Harvey, Pierre Dumas, Johanne Tremblay, Renata Ciftova, Philip Awadalla, Francois Madore, Pavel Hamet

The study team evaluated the impact of candidate variants in the main urate transporter genes, and also they examined the urumodulin/sodium excretion as mediators of the association between FEUA and uACR. Out of the 737 participants, 593 were observed in the final analysis. They found that there was an association between albuminuria with decreased renal urate excretion may be modified by the transporter SLC2A9.

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2019

Diet quality and risk factors for cardiovascular disease among South Asians in Alberta.

Authors: CB Chan FB Subhan

A retrospective analysis of data collected from 140 South Asian adults participating in the Alberta’s Tomorrow Project was conducted. Dietary intake was assessed using a questionnaire and the Healthy Eating Index (HEI) was used an indicator of overall diet quality and adherence to dietary recommendations made by Health Canada. Central obesity (70%), hypercholesterolemia (27%), and hypertension (14%) were predominant health conditions observed in the study participants.

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2019

Exome Sequencing in BRCA1- and BRCA2-Negative Greek Families Identifies MDM1 and NBEAL1 as Candidate Risk Genes for Hereditary Breast Cancer.

Authors: Stavros Glentis,Alexandros C. Dimopoulos, Konstantinos Rouskas, George Ntritsos, Evangelos Evangelou, Steven A. Narod, Anne-Marie Mes-Masson, William D. Foulkes, Barbara Rivera, Patricia N. Tonin, Jiannis Ragoussis, and Antigone S. Dimas

This study used CARTaGENE control data to find there relationship between the BRAC1-2 genes and breast cancer

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2019

Impact of adherence to cancer-specific prevention recommendations on subsequent risk of cancer in participants in Alberta’s Tomorrow Project.

Authors: JY Xu, JE Vena, HK Whelan, PJ Robson

This study wanted to see if cancer-specific recommendations actually prevented cancer. They found that those who adhered to said recommendations saw lower risk of develop cancer over time.

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