Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2015

Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals

Authors: Rana EL-Bikai, Muhammad Tahir, Johanne Tremblay, Michel Joffres, Ondřej Šeda, Lucie Šedová, Philip Awadalla, Claude Laberge, Bartha-Maria Knoppers, Pierre Dumas, Daniel Gaudet, Louis-Georges Ste-Marie, Pavel Hamet

They wanted to determine if there was an association with height, arterial stiffness, and bone fractures. They were able to determine at the end of the study that those with shorter statures were more likely to have arterial stiffness and hypertension.

Read Publication
2015

Leisure-Time Physical Activity Does not Attenuate the Association Between Occupational Sedentary Behavior and Obesity: Results From Alberta’s Tomorrow Project.

Authors: Joshua Nicholas, Geraldine Lo Siou, Brigid Lynch, Paula Robson, Christine Friedenrich, and Ilona Csizmadi

Using ATP data, this study determined that those in sedendary jobs are more at higher risk of obesity and was not attenuated by physical activity. Women did not show the same risk with sedendary behaviour.

Read Publication
2014

The Sedentary Time and Activity Reporting Questionnaire (STAR-Q): reliability and validity against doubly labeled water and 7-day activity diaries.

Authors: Ilona Csizmadi, Heather K. Neilson, Karen A. Kopciuk, Farah Khandwala, Andrew Liu, Christine M. Friedenreich, Yutaka Yasui, Rémi Rabasa-Lhoret, Heather E. Bryant, David C. W. Lau, and Paula J. Robson

The research team put together a STAR-Q to estimate past-month energy expenditure. They looked at 102 adults over a two week period. The STAR-Q demonstrated substantial validity for estimating occupational sedentary time and strenuous activity and fair validity for ranking individuals by AEE.

Read Publication
2014

Conditions Associated with Circulating Tumor-Associated Folate Receptor 1 Protein in Healthy Men and Women

Authors: Linda Keleman, James Brenton, Christine Parkinson, Hayley Whitaker, Anna Piskorz, Ilona Csizmadi, Paula Robson

This article examined how FOLR1 protein could potentially be way to detect early cancer. The team used electrochemical luminescence immunoassay. The study concluded that they should use caution when saying that serum FOLR1 can detect early cancer as there has not been a study with enough evidence to truly determine that.

Read Publication
2014

Geostatistical modelling of arsenic in drinking water wells and related toenail arsenic concentrations across Nova Scotia, Canada.

Authors: Trevor Dummer, Z.M. Yu, L. Nauta., J.D. Murimboh, L. Parker

This paper looked at the spatial variation of toenail arsenic concentration, they found that because of geological and environmental contaminants in well water there are higher levels of arsenic concentraion in human bodies.

Read Publication
2014

Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy

Authors: Kristopher Kahle, Nancy Merner, Perrine Friedel, Liliya Silayeva, Bo Liang, Arjun Khanna, Yuze Shang, Pamela LaChance-Touchette, Cynthia Bourassa, Annie Levert, Patrick Dion, Brian Walcott, Dan Spiegelman, Alexandre Dionne-Laporte, Alan Hodgkinson, Philip Awadalla, Hamid Nikbakht, Jacek Majewski, Patrick Cossette, Tarek Deeb, Stephen Moss, Igor Medina, Guy Rouleau

These data describe a novel KCC2 variant significantly associated with a human disease and suggest genetically encoded impairment of KCC2 functional regulation may be a risk factor for the development of human IGE.

Read Publication
2014

High-Resolution Genomic Analysis of Human Mitochondrial RNA Sequence Variation

Authors: Alan Hodgkinson, Youssef Idaghdour, Elias Gbeha, Jean-Christophe Grenier, Eloide Hip-Ki, Vanessa Bruat, Jean-Philippe Goulet, Thibault de Malliard, Philip Awadalla

The researchers sequenced ~1000 individuals mitochondrial RNA and a significant variation of sequences that show patterns of posttranscriptional modication. CARTaGENE samples were used to identify this information.

Read Publication
2014

What is the role of obesity in the aetiology of arsenic-related disease?

Authors: Zhijie M.Yu BryanFung John D.Murimboh LouiseParker Trevor J.B.Dummer

They took a large number of samples from people in Nova Scotia and determined that those who were obese had lower levels of arsenic concentrations in their bodies. The samples were taken from 960 people aged 35-60 between 2009-2010. Dietary patterns were also assessed along with drinking water.

Read Publication
2014

Understanding the translation of scientific knowledge about arsenic risk exposure among private well water users in Nova Scotia

Authors: Heather Chappells, Norma Campbell, John Drage, Conrad Fernandez, Louise Parker, Trevor Dummer

This article explored the knowledge of arsenic risk exposure among a well users in 5 areas of Nova Scotia assessed to be at risk of arsenic occurrence in groundwater. The risk ranged from low-high and was assessed over time. It was found that more women were at risk, where 71% of affected well-users were women. About 74% had a really good knowledge of the well water. A fair number of these people use their water as their drinking and 33% seemed confident the water was safe to drink.

Read Publication
2014

Intrapersonal and social environment correlates of leisure-time physical activity for cancer prevention: a cross-sectional study among Canadian adults.

Authors: Fabiola Aparicio-Ting, Christine Friedenreich, Karen Kopciuk, Ronald Plotnikoff, Heather Bryant

This study looked at physical activity and cancer prevention . The study team used self-administered questionnares and monitored how much exercise each test subject got. The were able to determine that adults do not really get enough exercise for cancer risk reduction.

Read Publication