Prediction of Cardiovascular Events by Pulse Waveform Parameters: Analysis of CARTaGENE
Researchers conducted the largest study to date evaluating non-invasive pulse waveform parameters’ association with cardiovascular events. By adding two waveform parameters to the existing atherosclerotic cardiovascular disease score, they improved cardiovascular prediction and reclassified up to 5.7% of patients in another risk category.
Cohort Profile: The Ontario Health Study (OHS)
OHS’s cohort profile outlines its research platform’s history and value for the broader scientific community. OHS follows 225,000 over their lifetime, actively and passively, making de-identified genomic, environmental, lifestyle, and electronic health data available to cancer and chronic disease researchers.
Arsenic Speciation and Metallomics Profiling of Human Toenails as a Biomarker to Assess Prostate Cancer Cases: Atlantic PATH Cohort Study
This study aimed to characterize arsenic species and metallome profiles in toenails and urine samples, compare these profiles between prostate cancer cases and controls, and evaluate the utility of toenail and urine biomarkers. Toenails were found to be viable biomarkers for altered arsenic speciation in prostate cancer cases.
Associations between neighbourhood street connectivity and sedentary behaviours in Canadian adults: Findings from Alberta’s Tomorrow Project
Researchers aimed to estimate associations between street connectivity, based on space syntax-derived street integration, and sedentary behaviours. Using data from 14,758 Alberta’s Tomorrow Project participants, they found that connectivity was positively related to various measures of sitting time and negatively associated with motor vehicle travel time.
Developing a Socioeconomic Status Index for Chronic Disease Prevention Research in Canada
Researchers developed a socioeconomic status (SES) index and assessed its associations with smoking amongst 17,371 Alberta’s Tomorrow Project participants. They found that their index was negatively related to smoking intensity.
Cross-sectional and longitudinal associations between the built environment and walking: effect modification by socioeconomic status
Using data from 703 Alberta’s Tomorrow Project participants, researchers found that changes to the built environment are not associated with changes in walking amongst adults after relocation. They also had weak findings that changes in walkability due to relocation may more strongly affect walking for adults with lower socioeconomic status.
Substituting bouts of sedentary behavior with physical activity: adopting positive lifestyle choices in people with a history of cancer
This study aimed to determine the association between substituting sitting time with other daily activities and changes in waist circumference amongst people with cancer history. The researchers found that small changes to minimize their sitting time help reduce waist circumference, possibly offsetting other adverse health outcomes.
Anti-Hyperglycemic Medication Adherence and Health Services Utilization in People with Diabetes: A Longitudinal Study of Alberta’s Tomorrow Project
This study aimed to describe how time-varying anti-hyperglycemic medication adherence relates to healthcare utilization for those with diabetes. Using data from Alberta’s Tomorrow Project participants, researchers found that poor drug adherence related to higher healthcare utilization in the short term but less over the long term.
Applying Machine Learning to Arsenic Species and Metallomics Profiles of Toenails to Evaluate Associations of Environmental Arsenic with Incident Cancer Cases
This preliminary study aimed to understand the association between environmental metal pathogenicity and carcinogenicity and prostate cancer. Researchers used toenails to capture arsenic exposure!
Analyzing cohort studies with interval-censored data: A new model-based linear rank-type test
When analyzing cohort studies with interval-censored data, the researchers suggest that statisticians employ their proposed test to test survival distributions’ quality between two or more groups.