Design, methods and demographics from phase I of Alberta’s Tomorrow Project cohort: a prospective cohort profile
This article describes Phase I of the ATP which looks at investigators that influence cancer and other diseases. Adults with no previous cancer were recruited and enrolled. 99% of those recruited agreed to be linked with administrative data bases. It was a very successful recruitment process.
A haplotype-based normalization technique for the analysis and detection of allele specific expression
The research team examined allele specific expression which can be an identifier for disease loci. They were able to sequence exomes from CARTaGENE cohort and find a significant association between the proportion of sites undergoing ASE within the genome and smoking.
Prediabetes, depressive and anxiety symptoms, and risk of type 2 diabetes: A community-based cohort study
This study looked at the effect of prediabetes/depression on a diabetes risk. It seemed that prediabetes/depression interacted and resulted in a diabetes increase. Depression has doubled the risk of prediabetes progressing into full on diabetes. Anxiety has also heightned the risk of prediabetes turning into diabetes.
Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) – a Pan Canadian cohort study
Canadian Alliance for Healthy Hearts and Minds (CAHHM) is a pan-Canadian, prospective, multi-ethnic cohort study being conducted in Canada. This project has sed CPTP data to help and assist it. CAHHM is a prospective cohort study which aims to examine the health of adults living in Canada.
Dietary assessment is a critical element of health research – Perspective from the Partnership for Advancing Nutritional and Dietary Assessment in Canada
This was an opinion based paper which argued that while assessing dietary intakes is difficult, it`s not impossible. They believe that building capacity and funding opportunities should be readily available in order to build research. If they were to have these, there would be better understanding in Canada and elsewhere.
Environments Associated with Moderate-to-Vigorous Physical Activity and Sedentary Behavior of Colorectal Cancer Survivors
The reseachers sought to discover locations where CRC survivors engage in PA and SB in order to inform health promoting interventions. It was found that most physical activity (73.7%) took place at home. It was argued the home environment is important to think about when considering how to make people more active.
Maelstrom Research guidelines for rigorous retrospective data harmonization
This article looked at the best ways to do data harmonization. By adhering to the proposed guidelines, the researchers sought to find the best way getting clean data. They found that by adhering to the guidelines, data harmonization can be easier to undertake.
Impact of the X Chromosome and sex on regulatory variation
The research team analyzed blood transcriptomes of 922 individuals and they were able to conduct the first large-scale genome wide analysis of sex/genetic variation patterns. They generated chromatin and were able to develop genome-wide insight into how genetic variation shape human gene regulation and disease.
Central blood pressures in early chronic kidney disease: an analysis of CARTaGENE
The research question for this study was whether CKD is associated with high blood pressure. They found that early CKD is not associated with detrimental central hemodynamic parameters.
Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia
This study used encoding genetics to determine the relationship of schizophrenia