Cohort Profile: Alberta’s Tomorrow Project
This article outlined the rationale as to why the it was necessary to set up a large cohort in Alberta and it aruged its feasiblity in the CPTP project. They argued that the project has many strengths and the research that came out of it but also said that it has had some problems with its recruting phase. Finally the article outlined how the data can be obtained, and discussed its funding.
Association between Physical Activity and Health-Related Quality of Life in Adults with Type 2 Diabetes
They wanted to determine the association between those who met physical activity and health-related quality of life in adults with type II diabetes. The mean age of the study group was about 65, and 45% of participants were female. It was found that the majority of the sample size did not meet guidelines for physical activity.
Using national dietary intake data to evaluate and adapt the US Diet History Questionnaire: the stepwise tailoring of an FFQ for Canadian use
The research team evaluated the Canadian Diet History Questionnaire and adapt the US list for Canada. 4533 food and recipes were grouped into 268 food group and were measured against the different surveys. C-DHQ I and II were designed to optimize the capture of foods consumed in Canadian populationsé
G1 Gene-environment-lifestyle factors in breast cancer susceptibility: machine learning tools to build predictive models
This study hoped to build predictive models for personalized breast screening. They were able to develop good predictive models for etiologies that would cause disease, and hope their model will aid in preventing breast cancer.
Conditions Associated with Circulating Tumor-Associated Folate Receptor 1 Protein in Healthy Men and Women
This article examined how FOLR1 protein could potentially be way to detect early cancer. The team used electrochemical luminescence immunoassay. The study concluded that they should use caution when saying that serum FOLR1 can detect early cancer as there has not been a study with enough evidence to truly determine that.
Intrapersonal and social environment correlates of leisure-time physical activity for cancer prevention: a cross-sectional study among Canadian adults.
This study looked at physical activity and cancer prevention . The study team used self-administered questionnares and monitored how much exercise each test subject got. The were able to determine that adults do not really get enough exercise for cancer risk reduction.
Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm
The study design also encompassed the 11 variants from GWASs previously reported by various consortia between the years 2007-2009 to (i) enable comparisons of effect sizes, and (ii) identify putative prognostic variants across studies. All SNP associations reported with breast cancer were also adjusted for body mass index (BMI). We report a strong association with 4q31.22-rs1429142 (combined per allele odds ratio and 95% confidence interval = 1.28 [1.17-1.41] and P combined = 1.5×10(-7)), when adjusted for BMI.
Assessing SNP-SNP Interactions among DNA Repair, Modification and Metabolism Related Pathway Genes in Breast Cancer Susceptibility
Our results provide a framework for evaluating SNPs showing statistically weak but reproducible single-locus effects for epistatic effects contributing to disease susceptibility.
ETHNOPRED: a novel machine learning method for accurate continental and sub-continental ancestry identification and population stratification correction
This study looked at ways of getting around the limits of self-declared ancestry, ancestry information markers, genomic control, structured association, and principal component analysis. They found ETHNOPRED to be a good alternative.
Breast cancer prediction using genome wide single nucleotide polymorphism data
These researchers studied 696 female participants and used an SNC model to determine whether a new subject would develop breast cancer or not.