Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2019

Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease

Authors: Sonia S Anand, Jack V Tu, Dipika Desai, Phillip Awadalla, Paula Robson, Sébastien Jacquemont, Trevor Dummer, Nhu Le, Louise Parker, Paul Poirier, Koon Teo, Scott A Lear, Salim Yusuf, Jean-Claude Tardif, Francois Marcotte, David Busseuil, Jean-Pierre Després, Sandra E Black, Anish Kirpalani, Grace Parraga, Michael D Noseworthy, Alexander Dick, Jonathan Leipsic, David Kelton, Jennifer Vena, Melissa Thomas, Karleen M Schulze, Eric Larose, Alan R Moody, Eric E Smith, Matthias G Friedrich on behalf of the Canadian Alliance for Healthy Hearts and Minds Cohort

This study aimed to determine if simple cardiac risk scores are associated with certain MRI-deected subclinical cerebrovascular diseases. They found that the risk scores are significantly related with carotid wall volume, carotid intraplaque haemorrhage, and silent brain infarction amongst adults without known clinical cardiovascular disease.

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2019

The individual and combined effects of alcohol consumption and cigarette smoking on site-specific cancer risk in a prospective cohort of 26,607 adults: results from Alberta’s Tomorrow Project.

Authors: B Viner, AM Barberio, TR Haig, CM Fredenreich, D Brenner

This study examined the invidual and synergistic effects of modifiable lifestyle factors on overall cancer risks. The conclusions of this study were that while alcohol did not really cause a cancer risk, smoking was definitley attributed to be a factor wherein females were more affected. Those who smoked and drank were at a higher risk of developing colon/prostate cancers.

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2019

A methodologic framework to evaluate the number of cancers attributable to lifestyle and environment in Alberta

Authors: Anne Grundy, Christine M. Friedenreich, Abbey E. Poirier, Farah Khandwala, Darren R. Brenner

The team wanted to devise a way estimate the number of incident cancers that could be attributed to factors that can be varied or modified in someone`s life. They looked at 24 cancer risk factors and used estimates to quantify an exposure. By having this data, they can figure out ways to modify lifestyle and lower risk of cancer incidence.

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2019

Depressive symptoms and sleep problems as risk factors for heart disease: a prospective community study.

Authors: SS Deschenes, R Burns, E. Graham., N. Schmitz.

The goal of this study was to see if there was an association between depressive behavior, sleep problems and risk of developing heart disease in the sample population. Using CARTaGENE data, they were able to determine that depression and sleep disorders are independent factors of heart disease and area associated with a stronger risk of heart disease when occurring together.

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2019

Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing

Authors: Xiaojian Shao, Marie Hudson, Ines Colmegna, Celia Greenwood, Marvin Fritzler, Philip Awadalla, Tomi Pastinen, Sasha Bernatsky

They wanted to compare DNA methylation in subjects postivie/negative for anti-citrullinated protein antibodies which is a key marker for rheumatoid arthritis. They measured the DNA methylation of 137 subjects, 63 who were ACPA-positive, 66 were negative and 8 were self-reported with their rheumatoid arthritis.

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2019

The Relationship between Anthropometric Measures and Cardiometabolic Health in Shift Work: Findings from the Atlantic PATH Cohort Study

Authors: Ellen Sweeney, Zhijie Yu, Trevor Dummer, Yunsong Cui, Vanessa DeClerq, Cynthia Forbes, Scott Grandy, Melanie Keats, Louise Parker, Anil Adisesh

This article was written to evaluate the relationship between anthropomeric measures and cardiometabolic health in shift workers compared to non-shift workers. They looked at 4155 shift workers and 8258 non-shift workers. There was a slight risk of CVD, obesity, and diabetes among shift workers. It also shown that shift workers were 17% more likely to be obese and 27% more likely to have diabetes.

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2019

The Establishment of the Household Air Pollution Consortium (HAPCO)

Authors: H. Dean Hosgood, Madelyn Klugman, Keitaro Matuso, Alexandra White, Atusko Sadakane, Xiao-Ou Shu, Ruy Lopez-Ridaura, Aesun Shin, Ichiro Tsuji, Reza Malekzadeh, Nolwenn Noisel, Parveen Bhatti, Gong Yang, Eiko Saito, Shaifuir Rahman, Wei hu, Bryan Bassig, George Downward, Roel Vemeulen, Xiaonan Xue, Thomas Rohan, Sarah Abe, Philippe Broet, Eric Grant, Trevor Dummer, Nat Rothman, Manami Inoue, Martin Lajouis, Keun-Young Yoo, Hidemi Ito, Dale Sandler, Habib Ashan, Wei Zheung, Paolo Boffetta, Qing Lan

This article looked at some of the dangers surrounding household air pollution and and it’s association with lung cancer. The Household Air Pollution Consortium will make sure that there is research being done to address public health concerns associated with HAP.

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2019

Anthropometric changes and risk of diabetes: are there sex differences? A longitudinal study of Alberta’s Tomorrow Project

Authors: Ming Ye, Paula Robson, Dean Eurich, Jennifer Vena, Jian-Yi Xu, Jefferey A Johnson

The objective this was study was see if there was an association with antropometric change and risk of diabetes. There was a positive association between anthropometric changes and risk of diabetes was found more in men than women.

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2019

Diet quality and risk factors for cardiovascular disease among South Asians in Alberta.

Authors: CB Chan FB Subhan

A retrospective analysis of data collected from 140 South Asian adults participating in the Alberta’s Tomorrow Project was conducted. Dietary intake was assessed using a questionnaire and the Healthy Eating Index (HEI) was used an indicator of overall diet quality and adherence to dietary recommendations made by Health Canada. Central obesity (70%), hypercholesterolemia (27%), and hypertension (14%) were predominant health conditions observed in the study participants.

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2019

Harmonization of the Health and Risk Factor Questionnaire data of the Canadian Partnership for Tomorrow Project: a descriptive analysis

Authors: Isabel Fortier, Nataliya Dragieva, Matilda Saliba, Camille Craig, Paula J. Robson

This paper describes how data is harmonized the health and risk factor questionnare and provides an overview of information required to use the core data that has been created. The reason for the harmonization is to have a unique data set including data on health and risk factors from over 307000 Canadians.

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