These publications are examples of research made possible with data from CanPath and its regional cohorts.


The influence of smoking and occupational risk factors on DNA methylation in the AHRR and F2RL3 genes

Authors: Laura Pelland-St-Pierre, Michael C Pham, Alice Quynh Huong Nguyen, Romain Pasquet, Sherryl A Taylor, Delphine Bosson-Rieutort, Anita Koushik, Vikki Ho

The researchers aimed to determine the association between smoking, occupational exposures, and AHRR and F2RL3 methylation, as AHRR and F2RL3 hypomethylation has been associated with lung cancer. A case-control study was implemented with CARTaGENE participants to outline the relationship between AHRR and F2RL3 methylation and lung cancer risk. It was found that in both the AHRR and F2RL3 genes, smoking was associated with lower levels of methylation. The data indicates that smoking and occupational exposures to some agents are associated with AHRR and F2RL3 hypomethylation.

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Occupational Exposures and Lung Cancer Risk – An Analysis of the CARTaGENE Study

Authors: Saeedeh Moayedi-Nia, Romain Pasquet, Jack Siemiatycki, Anita Koushik, Vikki Ho

This study aimed to understand the relationship between common occupational agents (e.g., ashes, cooking fumes) and lung cancer risk. Researchers found that increased lung cancer risk was linked to many of these agents, but lower lung cancer risk was found among those exposed to carbon monoxide and polycyclic aromatic hydrocarbons from petroleum.

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