The influence of smoking and occupational risk factors on DNA methylation in the AHRR and F2RL3 genes
The researchers aimed to determine the association between smoking, occupational exposures, and AHRR and F2RL3 methylation, as AHRR and F2RL3 hypomethylation has been associated with lung cancer. A case-control study was implemented with CARTaGENE participants to outline the relationship between AHRR and F2RL3 methylation and lung cancer risk. It was found that in both the AHRR and F2RL3 genes, smoking was associated with lower levels of methylation. The data indicates that smoking and occupational exposures to some agents are associated with AHRR and F2RL3 hypomethylation.
Occupational Exposures and Lung Cancer Risk – An Analysis of the CARTaGENE Study
Cette étude visait à comprendre la relation entre des agents professionnels courants (p. ex., les cendres, les fumées de cuisson) et le risque de cancer du poumon. Les chercheurs ont constaté que l’augmentation du risque de cancer du poumon était liée à de nombreux agents. Néanmoins, le risque de cancer du poumon était plus faible chez les personnes exposées au monoxyde de carbone et aux hydrocarbures aromatiques polycycliques dérivés du pétrole.