Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2020

Assessing arsenic in human toenail clippings using portable X-ray fluorescence

Authors: David Fleming, Samantha Crook, Colby Evans, Michel Nader, Manuel Atia, Jason Hicks, Ellen Sweeney, Christopher McFarlane, Jong Song Kim, Erin Keltie, Anil Adsesh

Single toenail clippings from 60 Atlantic Canadian participants were assessed for arsenic using a new portable X-ray fluorescence approach. The portable XRF technique used in this study shows promise as a means of assessing arsenic concentration in toenail clippings.

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2020

Diet Quality and Neighborhood Environment in the Atlantic Partnership for Tomorrow’s Health Project

Authors: Kaitlyn Gilham, Qianqian Gu, Trevor Dummer, John Spinelli, Rachel Murphy

This study looked at the differences that exist beween diet quality and someone’s geographical location. It was found that diet quality tended to be lower in areas that were were more socially deprived. Areas with socially deprived and high-density areas were associated with lower-quality data.

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2020

Assessing the Variation within the Oral Microbiome of Healthy Adults

Authors: Jacob Nearing, Vanessa DeClerq, Johan Van Limbergen, Morgan Langille

This study examined the salivary oral microbiome of 1,049 Atlantic Canadians using 16S rRNA gene sequencing to determine which dietary, lifestyle, and anthropometric features play a role in shaping microbial community composition. Results showed that while many features were significantly associated with oral microbiome composition, no single biological factor explained a variation larger than 2%.

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2020

Sunlight exposure, sun‐protective behaviour, and anti‐citrullinated protein antibody positivity: A general population‐based study in Quebec, Canada

Authors: Naizhou Zhao, Audrey Smargiassi, Ines Colmegna, Marie Hudson, Marvin Fritzer, Sasha Bernatsky

This study examined associations between sunlight exposure and anti-citrullinated protein antibodies (ACPA) using general population data in Quebec. The research team studied 7600 people and did not find conclusive associations, but robust positive relationships were observed between industrial PM2.5 emissions and ACPA.

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2020

High-sensitivity C-reactive protein, hemoglobin A1c and breast cancer risk: a nested case–control study from Alberta’s Tomorrow Project cohort

Authors: Tiffany Price, Christine Friedenreich, Paula Robson, Haocheng Li, Darren Brenner

This study examined the associations between high-sensitivity C-reactive protein (hsCRP) and hemoglobin A1c (HbA1c), common biomarkers of inflammation and insulin resistance, respectively, with breast cancer risk, while adjusting for measures of excess body size. These data suggest that hsCRP may be associated with elevated breast cancer risk, independent of excess body size. However, elevated concentrations of HbA1c did not appear to increase breast cancer risk in apparently healthy women.

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2020

Diet Quality and Health Service Utilization for Depression: A Prospective Investigation of Adults in Alberta’s Tomorrow Project

Authors: Shelby Marozoff, Paul Veugelers, Julia Dabravolskaj, Dean Eurich, Ming Ye, Katerina Maximova

This study investigated the association of depression with diet quality by studying dietary patterns of 25,016 participants in the Alberta cohort using data from the past year food frequency questionnaire. It was found that higher quality diets were associated with a lower number of physician visits for depression.

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2020

The Canadian Alliance for Healthy Hearts and Minds: How well does it reflect the Canadian population?

Authors: Ruth E. Hall, Natasa Tusevljak, C. Fangyun Wu, Quazi Ibrahim, Karleen Schulze, Anam M. Khan, Dipika Desai, Philip Awadalla, Philippe Broet, Trevor J.B. Dummer, Jason Hicks, Jean-Claude Tardif, Koon K. Teo, Jennifer Vena, Douglas Lee, Matthias Friedrich, Sonia S. Anand, Jack V. Tu

The representativeness of the Canadian Alliance for Healthy Hearts and Minds (CAHHM-HSR) cohort was evaluated by comparing to region matched respondents of the 2015 Canadian Community Health Survey Rapid Response module (CCHS-RR). CAHHM-HSR participants were older, more often women, more likely Chinese, and had higher education, hypertension, hypercholesterolemia and cardiac testing than the general Canadian population. Despite these differences, the INTERHEART risk score was similar.

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2020

Portable X-ray Fluorescence of Zinc Applied to Human Toenail Clippings

Authors: David E.B.Fleming, Samantha L. Crook, Colby T. Evans, Michel N. Nader, Manuel Atia, Jason M. T. Hicks, Ellen Sweeney, Christopher R. McFarlane, Jong Sung Kim, Erin Keltie, Anil Adisesh

The purpose of this study was to see if it was feasible to measure the zinc levels in the fingernails of people. They used an x-ray fluorescence to measure how much zinc was present in the nails. It was found that the latter was very sensitive at detecting zinc in the nail and would be able to measure fluctuating levels of zinc as time went on.

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2020

Burden of multimorbidity and polypharmacy among cancer survivors: a population-based nested case–control study

Authors: Melanie Keats, Yunsong Cui, Vanessa DeClerq, Scott Grandy, Ellen Sweeney, Trevor Dummer

The purpose of this study was to investigate if adult cancer survivors showed more than one comorbidity while taking medications. The article found multimorbities in 53% of cancer survivors. Those on multiple medications showed much higher results.

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2020

Long-term exposure to a mixture of industrial SO 2, NO 2, and PM 2.5 and anti-citrullinated protein antibody positivity

Authors: Naizhou Zhao, Audrey Smagiassi, Marianne Hatzopoulou, Ines Colmegna, Marie Hudson, Marvin Fritzler, Philip Awadalla, Sasha Bernatsky

The research team looked at exposures to SO2, NO2, and fine particles matter on anti-citrullinated protein antibodies, a characteristic biomarker for rheumatoid arthritis (RA). It was found that there was a positive correlation between ACPA and industrial emissions of PM2.5 and SO2.

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