Uric acid association with pulsatile and steady components of central and peripheral blood pressures
The objective of this study was to determine if the cardiovascular risk is attributed to elevated uric acid levels may be explained by changes in central/peripheral pulsatile and or steady blood pressure. After doing a multivariate analysis of over 20000 people, they determined that serum uric acid levels appear to be associated with both central/peripheral steady but not plausible BP, regardless of sex.
Relaxed Selection During a Recent Human Expansion
They assessed genealogies of French Canadians going back to the 17th century (over 4000 ascending geneaologies). With comparison of exomic diversity it revealed: i) both new and low-frequency variants are signficantly more deletrious mutations are at higher frequencies in front individuals, ii)equally deleterious mutations are at higher mutations in front individuals, iii) front individuals are two times more likely to be homozygous for rare very deletrious mutations ins europeans.
A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French–Canadian Population
They wanted to see if there was an association between LBX1 polymorphisms and adolescent scoliosis. They looked at 1568 participants and did the appropiate genotyping on them. They concluded that they replicated the association of LBX1 locus with AIS in the french canadian population.
Polygenic risk scores distinguish patients from non‐affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi‐affected kindreds
This study confirmed the usefulness of PRS in capturing the contribution of common genetic variants to the risk of SZ and BD in densely affected families.
Measures of excess body weight and anthropometry among adult Albertans: cross-sectional results from Alberta’s tomorrow project cohort
In this article they described the prevalence of excess body weight and abdominal obesity in participants with ATP. In this study, 76.8% of men and 59.5% of women reported a BMI of 25% or greater. As such many of the people studied were overweight and two thirds reported abdominal obesity. They will encourage the Albertans to improve their energy balance and reduce the burden of chronic disease.
Systemic use of antibiotics and risk of diabetes in adults: A nested case‐control study of Alberta’s Tomorrow Project
The study looked at the relationship between use of antibiotics and risk of diabetes. For this study they did a case control assessment and used logistical regression to determine the relationship between diabetes and antibitoics. They looked at 1676 cases and 13401 controls. They found 17.9% received more than 5 courses of antibiotics compared to 13.8% of controls. They found after adjusting for clinical and difficult-to-capture lifestyle data we found no association between systemic use of antibiotics and risk of diabetes.
Patterns and predictors of adherence to colorectal cancer screening recommendations in Alberta’s Tomorrow Project participants stratified by risk
The research team wanted to determine how colorectal cancer screening was relevant to modifiable behavior for cancer control. They looked at 9641 particpants and were grouped based on their age, family history, and etiology. Screening status was compared between enrollment and follow up to determine a screening pattern over time. It was determined that 77% of participants fell into an average-risk level, based on their age. However 90+% of people were at a higher risk based on their family history status. Many people did not do their CRC screening (less than 50%). They would have to take a closer look at the risk strata to determine how bad the risk is.
Perceived Susceptibility to Developing Cancer and Cancer Screening Behaviour: A Longitudinal Analysis of Alberta’s Tomorrow Project
Using data from the ATP cohort, this thesis asked the research questions: 1) Is PS to developing cancer associated with the incidence of mammography,
prostate-specific antigen, sigmoidoscopy, and colonoscopy screening tests? 2) Does an individual’s
perceived susceptibility affect screening behaviour differently between tests?
Association between Diet Quality and Adiposity in the Atlantic PATH Cohort
This research was done to assess the association between diet quality and adiposity. They found that the diet quality was very different among provinces, an area of concern was people who consumed only 1-2 servings of fruits/vegetables today. Adiposity was positively associated with consumption of excess meat, snack foods, sweetners, diet soft drinks, and fast food. It was shown that people who ate whole grains and green tea had lower levels of adiposity.
Cohort Profile: The Atlantic Partnership for Tomorrow’s Health (Atlantic PATH) Study
The PATH study wants to 1) develop a databank containing health/health-related measures 2) encourage/facilitate use of the databank . The idea is to provide information about risk factors for disease and then hopefully prevent it.