Gene-by-environment interactions in urban populations modulate risk phenotypes
From ∼1000 individuals of a founder population in Quebec, we reveal a substantial impact of the environment on the transcriptome and clinical endophenotypes, overpowering that of genetic ancestry. Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry.
Development of an on-line interactive map to display environmental health assessments of Canadian communities: knowledge-translation to support collaborations for health
This report describes an on-line interactive map developed by the Canadian Alliance for Healthy Hearts and Minds. It contains information from over 2,000 communities across Canada!
Plasma-Derived Inflammatory Proteins Predict Oral Squamous Cell Carcinoma
This study looked at a multiplex approach to screen plasma derived biomarkers and to examine the association of proteins with throat cancer. They looked at 260 plasma samples and they screened 82 biomarkers to look for disease.
The author who wasn’t there? Fairness and attribution in publications following access to population biobanks
This study conducted a document analysis that looked at publication ethics and authorship with population biobanks. In their findings, they reported a 3-step approach: 1) the biobank should be given proper acknowledgement 2) co-authorship should be encouraged to foster colloboration amongst researchers 3) referencing/citiations should be readily available
Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein Cholesterol
This study wanted to characterize the association of stains and LDL-c with central and brachial blood pressures and to quantify their respective effects. They looked 20004 partcipants, and 16507 of them had available central blood pressure. In conclusion, reduction of LDL-c was associated with only a fraction of the lower blood pressures in statin user and seemed to be mostly associated with improvement of steady (diastolic) pressure, whereas non–LDL-c–mediated pathways were mostly associated with changes in pulsatile pressure components.
Associations Between Depressive Symptoms and Indices of Obesity in Adults With Prediabetes and Normal Blood Glucose Levels: Results From the Emotional Health and Wellbeing Study
Depressive symptoms are associated with higher incident rates of dibaetes, but they are not sure if depressive symptoms are linked to prediabetes. The results from this study showed that there was depressive symptoms were positively associated with BMI, fat mass index, waist circumfrence in prediabetic adults. The assoications observed in people with prediabetes were stronger than those observed with normal blood glucose levels.
The 2017 American College of Cardiology/American Heart Association vs Hypertension Canada High Blood Pressure Guidelines and Potential Implications
This report compared the American and Canadian guidelines of Hypertension Canada and American College of Cardiology and American Heart Association and found that compared to the ACC/AHA guidelines it would result in increases of 8.7% in hypertension diagnosis and 3.4% of individuals needing treatment with 17.2% having a different BP target.
Uric acid association with pulsatile and steady components of central and peripheral blood pressures
The objective of this study was to determine if the cardiovascular risk is attributed to elevated uric acid levels may be explained by changes in central/peripheral pulsatile and or steady blood pressure. After doing a multivariate analysis of over 20000 people, they determined that serum uric acid levels appear to be associated with both central/peripheral steady but not plausible BP, regardless of sex.
Relaxed Selection During a Recent Human Expansion
They assessed genealogies of French Canadians going back to the 17th century (over 4000 ascending geneaologies). With comparison of exomic diversity it revealed: i) both new and low-frequency variants are signficantly more deletrious mutations are at higher frequencies in front individuals, ii)equally deleterious mutations are at higher mutations in front individuals, iii) front individuals are two times more likely to be homozygous for rare very deletrious mutations ins europeans.
A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French–Canadian Population
They wanted to see if there was an association between LBX1 polymorphisms and adolescent scoliosis. They looked at 1568 participants and did the appropiate genotyping on them. They concluded that they replicated the association of LBX1 locus with AIS in the french canadian population.