Co-consumption of Vegetables and Fruit, Whole Grains, and Fiber Reduces the Cancer Risk of Red and Processed Meat in a Large Prospective Cohort of Adults from Alberta’s Tomorrow Project
This study examined whether co-consumption of red and processed meat with key foods items and food constituents recommended for cancer prevention (vegetables and fruit, whole grains, and fiber) mitigates cancer incidence.
Association between lifestyle behaviors and frailty in Atlantic Canadian males and females
The aim of this study was to identify lifestyle factors in males and females that are associated with a degree of frailty in a Canadian cohort. Higher frailty was more prevalent among participants with unhealthy lifestyle behaviors related to smoking, alcohol consumption, sedentary and physical activity level, diet, and sleep.
Perceived susceptibility to developing cancer and screening for colorectal and prostate cancer: A longitudinal analysis of Alberta’s Tomorrow Project
This study looked at ATP participants screened between 2000-2008 to assess the association between perceived susceptibility of developing cancer and being screened via sigmoidoscopy/colonoscopy and prostate-specific antigen. Findings suggest health promotion can focus on targeting and heightening personal perceived susceptibility of developing cancer in jurisdictions with low screening rates for colorectal or prostate cancer.
Association between depressive symptoms, metabolic risk factors, and cognitive function: cross-sectional results from a community study in Quebec, Canada
This study investigated the cross-sectional association between depressive symptoms and metabolic risk factors with cognitive function in a middle-aged population. They found that comorbidity of depressive symptoms and MetD was associated with reduced cognitive performance in middle-aged adults without diabetes.
Associations between the neighbourhood characteristics and body mass index, waist circumference, and waist-to-hip ratio: Findings from Alberta’s Tomorrow Project
This study estimated the associations between neighbourhood characteristics and self-reported body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) risk categories among Canadian men and women.
The association between job strain, depressive symptoms, and cardiovascular disease risk: results from a cross-sectional population-based study in Québec, Canada
This study investigated whether there is an association between job strain and cardiovascular disease risk score, when depressive symptoms are controlled for. The results suggest that the job strain is associated with CVD risk score and that this association is not explained by depressive symptoms. Similar associations were observed for males and females.
Comparison of fracture prediction tools in individuals without and with early chronic kidney disease: A population-based analysis of CARTaGENE
This study analyzed the CARTaGENE cohort to see how patients with chronic kidney disease were affected by bone fractures.
Quantifying the Predictive Accuracy of a Polygenic Risk Score for Predicting Incident Cancer Cases: Application to the CARTaGENE Cohort
This study evaluated the 5-year predictivity of an 18-single nucleotide polymorphism PRS for incident breast cancer cases in the CARTaGENE cohort using pseudo R^2 indices. It concluded that the proposed pseudo-R^2 is easy to implement and well suited to evaluate PRS for predicting incident events in cohort studies.
Founder BRCA1/BRCA2/PALB2 pathogenic variants in French-Canadian breast cancer cases and controls
The purpose of this study was to evaluate the efficacy of genetic testing for these variants of the BRCA gene in Montreal French Canadians. A total of 555 breast cancer cases unselected for family history or age of diagnosis were genotyped, along with 1940 controls without a personal or family history of cancer. Almost 10% of the early onset cases of BC were heterozygous for founder BRCA1 or BRCA2. 7 of the 20 variants of the breast cancer gene tested for were found in this study.
The Relationship of Sleep Duration with Ethnicity and Chronic Disease in a Canadian General Population Cohort
This study used questionnaire data from the Ontario Health Study to determine how ethnicity-specific differences in sleep duration affect health outcomes. It was found that both sleep duration and ethnicity were independent significant predictors for various morbidities such as diabetes, stroke, and depression.