Risk factors for early-onset colorectal cancer: A Canadian prospective cohort study
Researchers aimed to determine associations between specific risk factors and early-onset colorectal cancer (eoCRC). Accordingly, the researchers utilized data from 127,852 healthy study participants who were less than 50 years of age and were either part of the Ontario Health Study cohort or the Alberta’s Tomorrow Project cohort. Ninety-eight cases of eoCRC were identified after an average follow-up of 6.63 years. Analyses indicated that a family history of CRC alone or with a history of other cancer types was associated with a heightened risk of developing eoCRC. However, there was no significant association between eoCRC and a family history of solely non-CRC cancer. Those classified as heavy smokers at baseline had a higher risk of eoCRC compared to non-smokers. Lastly, there were no significant associations between sex, socioeconomic factors, diabetes, alcohol consumption, and other factors with the risk of eoCRC.
Neighbourhood walkability and greenspace and their associations with health-related fitness in urban dwelling Canadian adults
The researchers aimed to outline sex-specific associations between the neighborhood built environment, grip strength, and body fat percentage of Canadian adults living in urban areas. They used cohort data from 4,052 males and 7,841 females who were part of Alberta’s Tomorrow Project. Negative associations were found between walkability and both grip strength and body fat percentage among males and females. Additionally, greenness showed a positive association with grip strength across both sexes, but this association was not observed with body fat percentage. These associations remained significant even after adjusting for physical activity and sitting.
Stage shifting by modifying the determinants of breast cancer stage at diagnosis: a simulation study
The researchers sought to understand how lifestyle factors influence the stage at which breast cancer is diagnosed. Using data from 492 participants in Alberta’s Tomorrow Project, they found that increasing dietary protein intake and reducing energy intake had the most significant impact. This suggests that minor lifestyle adjustments could potentially increase the rate of early-stage diagnoses by 12%, thereby informing cancer prevention strategies.
Dose-responsive effects of iron supplementation on the gut microbiota in middle-aged women
The researchers sought to investigate the association between iron supplementation and the gut microbiota among healthy female participants in Alberta’s Tomorrow Project. They found that adequate iron levels are essential for the overall health and wellbeing of women through their various life stages.
Microbial features linked to medication strategies in cardiometabolic disease management
Researchers explored the association of microbial structure with the use of single or multiple medications among participants from Alberta’s Tomorrow Project who were diagnosed with cardiometabolic disease. Forty-six associations were identified between microbial composition and single medications. Findings indicated that both single- and multiple medication use in cardiometabolic disease is associated with decreases in bacterial diversity, species, and microbial functional potential.
Subclinical primary aldosteronism and cardiovascular health: a population-based cohort study
This study explores the impact of subclinical primary aldosteronism, a less recognized form of hypertension characterized by renin-independent aldosterone production, on cardiovascular health. With data from 1284 CARTaGENE participants, researchers found that a higher aldosterone-to-renin ratio, indicative of this condition, was associated with increased arterial stiffness, adverse cardiac remodeling, and higher odds of developing hypertension, independent of traditional blood pressure measures.
Health-related and psychosocial factors associated with prostate cancer stage at diagnosis among males participating in Alberta’s Tomorrow Project
Researchers investigated the factors associated with the stage at which prostate cancer (PCa) is diagnosed among males in Alberta’s Tomorrow Project. They found that a higher number of lifetime prostate-specific antigen tests were linked to earlier-stage PCa, while higher abdominal circumference, lower social support, and having children were associated with later-stage disease.
The evolution of SARS-CoV-2 seroprevalence in Canada: a time-series study, 2020-2023
This study used data from the COVID-19 Immunity Task Force, which includes CanPath data, to track the prevalence of SARS-CoV-2 antibodies in the Canadian population over the pre-vaccination period, the vaccine rollout, and the emergence of the Omicron variant. By March 2023, over three-quarters of the population had detectable antibodies, with the most substantial increases seen after the arrival of the Omicron variant. However, variations in immunity by age and geography highlight the importance of tailoring public health policies and clinical decisions to local patterns of population immunity, considering factors like potential antibody decline and the emergence of new variants that might evade immunity.
Association of infertility with type and timing of menopause: a prospective cohort study
This study sought to uncover the association between past infertility and type and timing of menopause among midlife women. Using data from 13,243 midlife females from Alberta’s Tomorrow Project, the researchers found that women with past infertility were more likely to experience surgical menopause and had greater risk of earlier surgical menopause until age 43 years but experienced no differences in the timing of natural menopause.
The contributions of neighbourhood design in promoting metabolic health
Using data from 6,718 Alberta’s Tomorrow Project participants, the researchers assessed associations between neighbourhood built environment and metabolic syndrome, or the presence of at least three clinical risk factors among lipid levels, blood pressure, and waist circumference. They found that neighbourhoods with more points of interest and greater overall active living environment-friendliness were associated with fewer metabolic syndrome risk factors and lower odds of metabolic syndrome. Higher dwelling density was also linked to having fewer metabolic syndrome risk factors.