Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2018

The author who wasn’t there? Fairness and attribution in publications following access to population biobanks

Authors: Erika Kleiderman, Amy Pack, Pascal Borry, Ma'n Zawati

This study conducted a document analysis that looked at publication ethics and authorship with population biobanks. In their findings, they reported a 3-step approach: 1) the biobank should be given proper acknowledgement 2) co-authorship should be encouraged to foster colloboration amongst researchers 3) referencing/citiations should be readily available

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2018

Associations Between Depressive Symptoms and Indices of Obesity in Adults With Prediabetes and Normal Blood Glucose Levels: Results From the Emotional Health and Wellbeing Study

Authors: Rachel Burns, Soyna Deschenes, Norbert Schmitz

Depressive symptoms are associated with higher incident rates of dibaetes, but they are not sure if depressive symptoms are linked to prediabetes. The results from this study showed that there was depressive symptoms were positively associated with BMI, fat mass index, waist circumfrence in prediabetic adults. The assoications observed in people with prediabetes were stronger than those observed with normal blood glucose levels.

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2017

Genetic variations at the human growth hormone receptor (GHR) gene locus are associated with idiopathic short stature

Authors: Christel Dias, Mara Giordano, Rosalie Frenchette, Simonetta Bellone, Constantin Polychronakos, Laurent Legault, Cheri Deal, Cynthia Goodyer

The CARTaGENE cohort looked 168 inviduals with SS, and found 95% were of European Ancestry. These data suggest that the variants identified are potentially genetic markers specifically associated with the ISS phenotype.

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2017

Industrial air emissions, and proximity to major industrial emitters, are associated with anti-citrullinated protein antibodies

Authors: Sasha Bernatsky, Audrey Smargiassi, Lawrence Joseph, Philip Awadalla, Ines Colmega, Marie Hudson, Marvin Fritzler

They assessed the relationships between PM25, SO2, and ACPA which is a marker for RA, they found there was a positive association between ACPA and industrial PM2.5/SO2 emissions. Finally there was a correlation between air pollution from industrial emissions and ACPA suggests a role for these exposures in RA.

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2016

Prediabetes, depressive and anxiety symptoms, and risk of type 2 diabetes: A community-based cohort study

Authors: Sonya Deschenes, Rachel Burns, Eva Graham, Norbert Schimitz

This study looked at the effect of prediabetes/depression on a diabetes risk. It seemed that prediabetes/depression interacted and resulted in a diabetes increase. Depression has doubled the risk of prediabetes progressing into full on diabetes. Anxiety has also heightned the risk of prediabetes turning into diabetes.

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2016

Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) – a Pan Canadian cohort study

Authors: Sonia S. Anand, Jack V. Tu, Philip Awadalla, Sandra Black, Catherine Boileau, David Busseuil, Dipika Desai, Jean-Pierre Després, Russell J. de Souza, Trevor Dummer, Sébastien Jacquemont, Bartha Knoppers, Eric Larose, Scott A. Lear, Francois Marcotte, Alan R. Moody, Louise Parker, Paul Poirier, Paula J. Robson, Eric E. Smith, John J. Spinelli, Jean-Claude Tardif, Koon K. Teo, Natasa Tusevljak, Matthias G. Friedrich

Canadian Alliance for Healthy Hearts and Minds (CAHHM) is a pan-Canadian, prospective, multi-ethnic cohort study being conducted in Canada. This project has sed CPTP data to help and assist it. CAHHM is a prospective cohort study which aims to examine the health of adults living in Canada.

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2016

Maelstrom Research guidelines for rigorous retrospective data harmonization

Authors: Isabel Fortier, Parminder Raina, Edwin R Van den Heuvel, Lauren E Griffith, Camille Craig, Matilda Saliba, Dany Doiron, Ronald P Stolk, Bartha M Knoppers, Vincent Ferretti, Peter Granda, Paul Burton

This article looked at the best ways to do data harmonization. By adhering to the proposed guidelines, the researchers sought to find the best way getting clean data. They found that by adhering to the guidelines, data harmonization can be easier to undertake.

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2016

Depression and risk of type 2 diabetes: the potential role of metabolic factors

Authors: N. Schmitz, SS Deschenes, RJ Burns, J. Smith, A. Lesage, I. Strychar, R. Rabasa-Lhoret, C. Frieitas, E. Graham, P. Awadalla, JL Wang

This study looked at the interaction between depressive symptoms and metabolic dysregulations as risk factors for type II diabetes. The study found depressive symptoms and disruptions in metabolic regulation can lead to risk of type two diabetes.

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2015

Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis

Authors: Claire Leblond, Ziv Gan-Or, Dan Spiegelman, Sandra Laurent, Anna Szuto, Alan Hodgkinson, Alexandre Dionne-Laporte, Pierre Provencher, Mamde de Carvalho, Sandro Orru, Denis Brunet, Jean-Pierre Bouchard, Philip Awadalla, Nicholas Dupre, Patrick Dion, Guy Rouleau

In this study, they looked at mutations of MATR3 (gene that is associated with ALS). They assessed the frequency in French Canadian populations and had a control group. They were able to determine which proteins are associated with ALS.

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2015

Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross‐Sectional Analysis Among Nondiabetic Patients

Authors: Cristiano S. Moura, Stella S. Daskalopoulou, Linda E. Levesque, Sasha Bernatsky, Michal Abrahamowicz, Meytal A. Tsadok, Shadi Rajabi, Louise Pilote

This study used CARTaGENE data to determine to assess the noninferority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. No major differences were noted and it was shown that TDs are at least as effective as other first line medications that are available.

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