Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2024

Estimating Additive Interaction in Two-Stage Individual Participant Data Meta-Analysis.

Authors: M. Basten, L. A. van Tuijl, K. Y. Pan, A. W. Hoogendoorn, F. Lamers, A. V. Ranchor, J. Dekker, P. Frank, H. Galenkamp, M. J. Knol, N. Noisel, Y. Payette, E. R. Sund, A. H. Zwinderman, L. Portengen, M. I. Geerlings

The researchers aimed to describe how the Relative Excess Risk due to Interaction (RERI) and other measures of additive interaction or effect modification can be validly estimated within two-stage individual participant data (IPD) meta-analysis. They proposed a three-step procedure to estimate additive interaction, and illustrate this procedure by investigating interaction between depression and smoking and risk of smoking-related cancers incidence during follow-up, and used IPD of six cohorts, including CARTaGENE.

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