Stage shifting by modifying the determinants of breast cancer stage at diagnosis: a simulation study
The researchers sought to understand how lifestyle factors influence the stage at which breast cancer is diagnosed. Using data from 492 participants in Alberta’s Tomorrow Project, they found that increasing dietary protein intake and reducing energy intake had the most significant impact. This suggests that minor lifestyle adjustments could potentially increase the rate of early-stage diagnoses by 12%, thereby informing cancer prevention strategies.
Reduced incidence of diabetes during the COVID-19 pandemic in Alberta: A time-segmented longitudinal study of Alberta’s Tomorrow Project
Researchers aimed to outline the impact of the COVID-19 pandemic on diabetes diagnosis using data from participants who were part of Alberta’s Tomorrow Project. During the COVID-19 pandemic (up to 31 March 2021), the rate of diabetes diagnosis was 32% lower than pre-pandemic levels. The first COVID-19 state of emergency (first wave) was associated with an 87.3% reduction in diabetes diagnoses. This trend continued through the second COVID-19 state of emergency, and no notable increase in diagnoses was observed even after the state of emergency was relaxed. Ultimately, it was found that in Alberta, the COVID-19 public health emergencies had adverse consequences on diabetes diagnoses.
The influence of smoking and occupational risk factors on DNA methylation in the AHRR and F2RL3 genes
The researchers aimed to determine the association between smoking, occupational exposures, and AHRR and F2RL3 methylation, as AHRR and F2RL3 hypomethylation has been associated with lung cancer. A case-control study was implemented with CARTaGENE participants to outline the relationship between AHRR and F2RL3 methylation and lung cancer risk. It was found that in both the AHRR and F2RL3 genes, smoking was associated with lower levels of methylation. The data indicates that smoking and occupational exposures to some agents are associated with AHRR and F2RL3 hypomethylation.
Health-related and psychosocial factors associated with prostate cancer stage at diagnosis among males participating in Alberta’s Tomorrow Project
Researchers investigated the factors associated with the stage at which prostate cancer (PCa) is diagnosed among males in Alberta’s Tomorrow Project. They found that a higher number of lifetime prostate-specific antigen tests were linked to earlier-stage PCa, while higher abdominal circumference, lower social support, and having children were associated with later-stage disease.
The evolution of SARS-CoV-2 seroprevalence in Canada: a time-series study, 2020-2023
This study used data from the COVID-19 Immunity Task Force, which includes CanPath data, to track the prevalence of SARS-CoV-2 antibodies in the Canadian population over the pre-vaccination period, the vaccine rollout, and the emergence of the Omicron variant. By March 2023, over three-quarters of the population had detectable antibodies, with the most substantial increases seen after the arrival of the Omicron variant. However, variations in immunity by age and geography highlight the importance of tailoring public health policies and clinical decisions to local patterns of population immunity, considering factors like potential antibody decline and the emergence of new variants that might evade immunity.
Nonfasting remnant cholesterol and cardiovascular disease risk prediction in Albertans: a prospective cohort study
This study aimed to assess the relationship between nonfasting remnant cholesterol and cardiovascular disease (CVD) using data from 13,988 Alberta’s Tomorrow Project participants. The researchers found that nonfasting remnant cholesterol was positively associated with CVD incidence, whereas low-density lipoprotein (LDL) cholesterol was negatively associated with it.
Development and external validation of partial proportional odds risk prediction models for cancer stage at diagnosis among males and females in Canada
This study examined health patterns in Alberta’s Tomorrow Project participants before cancer diagnosis to find factors related to cancers caught early versus late. The researchers found factors then tested them in a similar group from the British Columbia Generations Project.
Non-fasting lipids and cardiovascular disease in those with and without diabetes in Alberta’s Tomorrow Project: A prospective cohort study
L’objectif de cette étude était d’évaluer la relation entre le cholestérol résiduel non à jeun (RC) et les maladies cardiovasculaires (MCV) chez les diabétiques et les non-diabétiques à l’aide des données de 13 631 participants à l’Alberta’s Tomorrow Project. Les chercheurs ont constaté qu’un taux élevé de cholestérol résiduel non à jeun était associé à un risque accru de MCV chez les adultes d’âge moyen et plus âgés non diabétiques.
Impact of Comorbidity on Hospitalization and Emergency Room Visits in Adults With Diabetes: A Longitudinal Study of Alberta’s Tomorrow Project
En utilisant les données du projet Alberta Tomorrow, Ye et al. ont étudié l’impact des comorbidités sur les hospitalisations et les visites aux urgences chez les personnes atteintes de diabète. Au cours des cinq années de l’étude, les auteurs ont observé un lien significatif entre le nombre de comorbidités et l’augmentation de l’utilisation des soins de santé parmi les 2 110 cas de la population étudiée.
Personalized breast cancer onset prediction from lifestyle and health history information
Cet article propose une méthode pour prédire quand une femme développera un cancer du sein (CaS) en fonction de son état de santé et de son mode de vie à l’aide des données de 18 288 femmes du projet Alberta Tomorrow. L’approche employée a fait ressortir sept caractéristiques liées au mode de vie qu’une femme peut modifier, afin de montrer comment le modèle peut prédire les effets de tels changements. Cette méthode peut être utilisée pour identifier les interventions pour les personnes ayant une plus grande probabilité de développer un CaS.