Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2016

Dietary assessment is a critical element of health research – Perspective from the Partnership for Advancing Nutritional and Dietary Assessment in Canada

Authors: Marie-Ève Labonté, Sharon I. Kirkpatrick, Rhonda C. Bell, Beatrice A. Boucher, Ilona Csizmadi, Anita Koushik, Mary R. L’Abbé, Isabelle Massarelli, Paula J. Robson, Isabelle Rondeau, Bryna Shatenstein, Amy F. Subar, and Benoît Lamarche

This was an opinion based paper which argued that while assessing dietary intakes is difficult, it`s not impossible. They believe that building capacity and funding opportunities should be readily available in order to build research. If they were to have these, there would be better understanding in Canada and elsewhere.

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2016

Environments Associated with Moderate-to-Vigorous Physical Activity and Sedentary Behavior of Colorectal Cancer Survivors

Authors: Logan Lawrence, Michelle Stone, Daniel Rainham, Melanie Keats

The reseachers sought to discover locations where CRC survivors engage in PA and SB in order to inform health promoting interventions. It was found that most physical activity (73.7%) took place at home. It was argued the home environment is important to think about when considering how to make people more active.

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2016

Maelstrom Research guidelines for rigorous retrospective data harmonization

Authors: Isabel Fortier, Parminder Raina, Edwin R Van den Heuvel, Lauren E Griffith, Camille Craig, Matilda Saliba, Dany Doiron, Ronald P Stolk, Bartha M Knoppers, Vincent Ferretti, Peter Granda, Paul Burton

This article looked at the best ways to do data harmonization. By adhering to the proposed guidelines, the researchers sought to find the best way getting clean data. They found that by adhering to the guidelines, data harmonization can be easier to undertake.

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2016

Impact of the X Chromosome and sex on regulatory variation

Authors: Kimberly Kukurba, Princy Parsana, Brunilda Balliu, Kevin Smith, Zachary Zappala, David Knowles, Marie-Julie Fave, Joe Davis, Xin Li, Xiaowei Zhu, James Potash, Myrna Weissman, Jianxin Shi, Anshul Kundaje, Douglas Levinson, Philip Awadalla, Sara Mostafavi, Alexis Battle, and Stephen Montgomery

The research team analyzed blood transcriptomes of 922 individuals and they were able to conduct the first large-scale genome wide analysis of sex/genetic variation patterns. They generated chromatin and were able to develop genome-wide insight into how genetic variation shape human gene regulation and disease.

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2016

Central blood pressures in early chronic kidney disease: an analysis of CARTaGENE 

Authors: Rémi Goupil, Dominique Dupuis, Mohsen Agharazii, Pavel Hamet, Stéphan Troyanov, François Madore

The research question for this study was whether CKD is associated with high blood pressure. They found that early CKD is not associated with detrimental central hemodynamic parameters.

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2016

Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia

Authors: Nancy Merner, Adriana Mercado, Arjun Khanna, Alan Hodgkinson, Vanessa Bruat, Philip Awadalla, Gerardo Gamba, Guy Rouleau, Kristopher Kahle

This study used encoding genetics to determine the relationship of schizophrenia

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2016

The mental health status of ethnocultural minorities in Ontario and their mental health care

Authors: Sherry Grace, Yongyao Tan, Robert Cribbie, Han Nguyen, Paul Rivito, Jane Irvine

The reason for this study was to compare the pyschosocial indicators and mental health service use among diverse populations in Ontario. There was a high level of pyschosocial distress in ethnic minorities in Ontario who are not accessing mental health services.

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2016

Depression and risk of type 2 diabetes: the potential role of metabolic factors

Authors: N. Schmitz, SS Deschenes, RJ Burns, J. Smith, A. Lesage, I. Strychar, R. Rabasa-Lhoret, C. Frieitas, E. Graham, P. Awadalla, JL Wang

This study looked at the interaction between depressive symptoms and metabolic dysregulations as risk factors for type II diabetes. The study found depressive symptoms and disruptions in metabolic regulation can lead to risk of type two diabetes.

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2016

Using national dietary intake data to evaluate and adapt the US Diet History Questionnaire: the stepwise tailoring of an FFQ for Canadian use

Authors: Ilona Csizmadi, Beatrice Boucher, Geraldine Lo Siou, Isabelle Massarelli

The research team evaluated the Canadian Diet History Questionnaire and adapt the US list for Canada. 4533 food and recipes were grouped into 268 food group and were measured against the different surveys. C-DHQ I and II were designed to optimize the capture of foods consumed in Canadian populationsé

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2016

A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility

Authors: Y Sapkota, A Narasimhan, M Kumaran, B. Sehrawat, S.Damaraju

The study wanted to determine which CNVs (copy number variations) are assoicated with sporadic BC. They also wanted to 2 distinct CNV calling algorithms to identify false positives and finally the aim of the study is identify potential candidate CNVs for follow-up replication studies.

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