Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians
This article looked at ways of predicting/preventing coronary artery disease. Polygenic risk scores based on the genome sequence can be a potential biomarker to predict the risk of CAD. Validation of PRS predictive power and transferability in other populations can support clinical utility.
Predictive value of quantitative ultrasound parameters in individuals with chronic kidney disease: A population-based analysis of CARTaGENE.
This study showed that early decrease in renal function increase calcancela ultrasound parameters, QUS is associated with fracture incidence regardless of renal function, QUS underestimates fracture incidence in patients with early CKD.
Genetic and epidemiological characterization of restless legs syndrome in Québec
This study aimed to assess these RLS predisposing genetic variants, as well as investigate the epidemiological profile and diagnostic features of individuals with RLS in the Québec population, using an interviewer-administered questionnaire
Validation of drug prescription records for senior patients in Alberta’s Tomorrow Project: Assessing agreement between two population-level administrative pharmaceutical databases in Alberta, Canada.
This study was done to examine the pharamceutical information network (PIN) and the Alberta Blue Cross dataset to see the medical records of all senior patients in Alberta matched up. It was found that the PIN had a fairly good completing at capuring the ABC medications for senior patients in Alberta.
Anxiety and depression symptoms in adult males in Atlantic Canada with or without a lifetime history of prostate cancer
In this study based on prostate cancer and to examine the assoication between depression and anxiety. They looked at sample size of 6585 participants and found surivors of PCa had 2.45 or 2.05 statistically significant higher odds of screening positive for anxiety/depression
A population-based study of the associations between neighbourhood walkability and different types of physical activity in Canadian men and women.
The purpose for this study was to determine whether there was difference between neighbourhood walkability differed amongst men/women. They examined perceived walkability and examined how the two sexes percevied walkability in their neighbourhoods.
Exome Sequencing in BRCA1- and BRCA2-Negative Greek Families Identifies MDM1 and NBEAL1 as Candidate Risk Genes for Hereditary Breast Cancer.
This study used CARTaGENE control data to find there relationship between the BRAC1-2 genes and breast cancer
Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease
This study aimed to determine if simple cardiac risk scores are associated with certain MRI-deected subclinical cerebrovascular diseases. They found that the risk scores are significantly related with carotid wall volume, carotid intraplaque haemorrhage, and silent brain infarction amongst adults without known clinical cardiovascular disease.
The individual and combined effects of alcohol consumption and cigarette smoking on site-specific cancer risk in a prospective cohort of 26,607 adults: results from Alberta’s Tomorrow Project.
This study examined the invidual and synergistic effects of modifiable lifestyle factors on overall cancer risks. The conclusions of this study were that while alcohol did not really cause a cancer risk, smoking was definitley attributed to be a factor wherein females were more affected. Those who smoked and drank were at a higher risk of developing colon/prostate cancers.
A methodologic framework to evaluate the number of cancers attributable to lifestyle and environment in Alberta
The team wanted to devise a way estimate the number of incident cancers that could be attributed to factors that can be varied or modified in someone`s life. They looked at 24 cancer risk factors and used estimates to quantify an exposure. By having this data, they can figure out ways to modify lifestyle and lower risk of cancer incidence.