Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2017

Relationship Between Adiponectin and apoB in Individuals With Diabetes in the Atlantic PATH Cohort

Authors: Vanessa DeClerq, Yunsong Cui, Trevor Dummer, Cynthia Forbes, Scott Grandy,Melanie Keats, Louise Parker, Ellen Sweeney, Zhijie Michael Yu, Roger McLeod

They waned to see if there was a relationship between biomarkers of apidose issue and cardiovasular comorbidities risk in BMI. They 480 people in their study, half of which were diabetic and half were not. It was found that plasma adiponectin levels were lower in diabetic patients than those who are not. Plasma apoB levels were similar between participants with and without diabetes.

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2017

Associations of Coffee, Diet Drinks, and Non-Nutritive Sweetener Use with Depression among Populations in Eastern Canada

Authors: Zhijie Yu, Lousie Parker, Trevor Dummer

They did a cross-sectional study to show the association between coffee/diet drinks/sweetners and depression. It was found there was a significant relationship between depression and consumption of sweetners/diet drinks. These symptoms were seen more in women than men.

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2017

Diet quality is associated with reduced incidence of cancer and self-reported chronic disease: Observations from Alberta’s Tomorrow Project

Authors: Nathan Solbak, Jian-Yi Xu, Jennifer Vena, Ilona Csizmadi, Heather Whelan, Paula Robson

This study looked at food quality and how it is associated with risk of cancer and chronic disease. There were 25169 participants enrolled and it was found that the better the diet quality, the lower the risk of cancer.

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2017

Lead in drinking water: a response from the Atlantic PATH study

Authors: Ellen Sweeney, Zhijie Yu, Louise Parker, Trevor Dummer

Most of the people who were being observed in this study were below the maximum level for lead intake, however the few that were the outliners are still cause for concern.

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2017

Atopic dermatitis and risk of hypertension, type 2 diabetes, myocardial infarction and stroke in a cross‐sectional analysis from the Canadian Partnership for Tomorrow Project

Authors: A.M. Drucker, A. Qureshi, T. Dummer, L. Parker, W. Li

This study wanted to determine if there was an association with atopic dermatitis and hypertension/heart attack/stroke/type II diabetes. It was found in a cross-sectional study that AD is not really a major risk factor for cardiovascular disease.

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2017

Genetic variations at the human growth hormone receptor (GHR) gene locus are associated with idiopathic short stature

Authors: Christel Dias, Mara Giordano, Rosalie Frenchette, Simonetta Bellone, Constantin Polychronakos, Laurent Legault, Cheri Deal, Cynthia Goodyer

The CARTaGENE cohort looked 168 inviduals with SS, and found 95% were of European Ancestry. These data suggest that the variants identified are potentially genetic markers specifically associated with the ISS phenotype.

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2017

Allele-specific expression reveals interactions between genetic variation and environment

Authors: David Knowles, Joe Davis, Hilary Edgington, Anil Raj, Marie-Julie Fave, Xiaowei Zhu, James Potash, Myrna Weissman, Jianxin Shin, Douglas Levinson, Philip Awadalla, Sara Mostafavi, Stephen Montgomery, Alexis Battle

Combining whole-blood RNA-seq with extensive environmental annotations collected from 922 human individuals, we identified 35 GxE interactions, compared with only four using standard GxE interaction testing. EAGLE provides new opportunities for researchers to identify GxE interactions using functional genomic data.

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2017

Industrial air emissions, and proximity to major industrial emitters, are associated with anti-citrullinated protein antibodies

Authors: Sasha Bernatsky, Audrey Smargiassi, Lawrence Joseph, Philip Awadalla, Ines Colmega, Marie Hudson, Marvin Fritzler

They assessed the relationships between PM25, SO2, and ACPA which is a marker for RA, they found there was a positive association between ACPA and industrial PM2.5/SO2 emissions. Finally there was a correlation between air pollution from industrial emissions and ACPA suggests a role for these exposures in RA.

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2017

Changes in body mass index and incidence of diabetes: A longitudinal study of Alberta’s Tomorrow Project Cohort

Authors: Ming Ye, Paula Robson, Dean Eurich, Jennifer Vena, Jian-Yi Xu, Jefferey A Johnson

The study objective was to figure out the association between BMI changes over a given period of time, and the number of new diabetes cases. When there was a BMI increase, there was a higher risk of developing diabetes and with the BMI reduction, there was lower risk of diabetes. This was the case for the those who were overweight, there was no association with underweight or normal BMI populations.

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2017

Multimorbidity in Atlantic Canada and association with low levels of physical activity

Authors: Melanie Keats, Yunsong Cui, Vanessa DeClercq, Trevor Dummer, Cynthia Forbes, Scott Grandy, Jason Hicks, Ellen Sweeney, Zhijie Yu, Louise Parker

It was reported that 38% of participants had 2 or more chronic diseases and women were more likely to be affected. People with multimorbid individuals were more likely to be inactive. It is important to implement physical activity prescription.

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