Addressing dispersion in mis-measured multivariate binomial outcomes: A novel statistical approach for detecting differentially methylated regions in bisulfite sequencing data
The researchers investigated the association between DNA methylation and levels of anti-citrullinated protein antibodies (ACPA), a preclinical marker for rheumatoid arthritis (RA) risk, using asymptomatic samples from the CARTaGENE cohort. Through targeted custom capture sequencing of whole blood, their analysis identified 23 significant genes potentially contributing to ACPA-related differential methylation. These findings emphasize the roles of cell signaling and collagen metabolism in RA.
The mental health status of ethnocultural minorities in Ontario and their mental health care
The reason for this study was to compare the pyschosocial indicators and mental health service use among diverse populations in Ontario. There was a high level of pyschosocial distress in ethnic minorities in Ontario who are not accessing mental health services.