These publications are examples of research made possible with data from CanPath and its regional cohorts.


Evidence that ovarian hormones, but not diet and exercise, contribute to the sex disparity in post-traumatic stress disorder

Authors: Megan Wiseman, Meagan Hinks, Darcy Hallett, Jacqueline Blundell, Ellen Sweeney, Christina Thorpe, Susan Walling, Ashlyn Swift-Gallant

Females are twice as likely as males to receive a diagnosis of post-traumatic stress disorder (PTSD). Using data from the Atlantic Partnership for Tomorrow’s Health (PATH) cohort of 16,899 participants, the relationship between endogenous hormone fluctuations (e.g., menarche, pregnancy, and menopause), exogenous hormone use (e.g., hormonal contraception and hormone replacement therapy (HRT)) and lifestyle variables (diet and exercise habits, as measured by the Mediterranean Diet Adherence Screener, Healthy Eating Index, and International Physical Activity Questionnaire) with PTSD diagnosis and treatment were analyzed. While several hormonal variables, including contraceptive use, higher total number of pregnancies, younger menarche age, and having undergone menopause increased the risk of PTSD, no lifestyle variables contributed to an increased risk of PTSD diagnosis.

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