Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2024

Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian casecontrol cohort

Authors: Véronique Boumtje, Hasanga D. Manikpurage, Zhonglin Li, Nathalie Gaudreault, Victoria Saavedra Armero, Dominique K. Boudreau, Sébastien Renaut, Cyndi Henry, Christine Racine, Aida Eslami, Stéphanie Bougeard, Evelyne Vigneau, Mathieu Morissette, Benoit J. Arsenault, Catherine Labbé, Anne-Sophie Laliberté, Simon Martel, François Maltais, Christian Couture, Patrice Desmeules, Patrick Mathieu, Sébastien Thériault, Philippe Joubert, Yohan Bossé

The researchers equipped a case-control dataset, consisting of 4002 lung cancer cases from the LORD project and 20,010 ethnically matched controls from the CARTaGENE cohort. The researchers aimed to generate a genome-wide polygenic risk score for lung cancer to improve risk prediction and delineate individuals at high genetic risk of lung cancer for earlier detection and prevention.

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