Provincial variation in colorectal cancer screening adherence in Canada; evidence from the Canadian Partnership for Tomorrow’s Health
The researchers sought to assess regional variation in screening uptake, identify factors to non-adherence to screening, and estimate adherence to screening in those with differing risk profiles. Using national CanPath data, they found adherence suboptimal amongst Canadians and noticed variation by region.
Toenail arsenic species and metallome profiles associated with breast, cervical, prostate, and skin cancer prevalence in the Atlantic Partnership for Tomorrow’s Health cohort
The purpose of this study was to characterize the profiles of arsenic species and metallome in the toenails of four cancer groups, compare them to healthy participants, and assess potential associations between the profiles with cancer prevalence.
Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer
Salivary samples from the Atlantic Partnership for Tomorrow’s Health (PATH) project and Alberta’s Tomorrow Project (ATP) to examine the existence of prostate, colon, and breast cancer biomarkers in the human oral microbiome. While no significant changes in oral microbiome diversity were detected, results indicate that there may be associations between oral microbiome and colon cancer disease status.
Mental health service use and associated predisposing, enabling and need factors in community living adults and older adults across Canada
The authors utilized data from the CanPath COVID-19 health survey (May to December 2020) to conduct multivariate logistic regression analysis to determine the association between mental health service use (MHSU) and predisposing, enabling, and need factors — derived from Andersen’s model of healthcare-seeking behaviour — among five regional cohorts. Among the 45,542 adults in the study population, 6.3% of respondents reported MHSU and need factors were consistently associated with MHSU.
Harnessing the power of data linkage to enrich the cancer research ecosystem in Canada
This abstract discusses a project aimed at linking cancer registry and administrative health data to Canada’s largest population health study, the Canadian Partnership for Tomorrow’s Health (CanPath). The project seeks to enrich the cancer research ecosystem in Canada by providing researchers with a comprehensive dataset that includes genetics, environment, lifestyle, and behaviour data. The linked data will be made available through a cloud-based solution called the CanPath Data Safe Haven, which is accessible to researchers through secure access. The project will address concerns related to the accessibility of cancer data in Canada, bring more value to existing data, and support an enhanced understanding of the impacts of cancer on marginalized populations.
Arsenic Speciation and Metallomics Profiling of Human Toenails as a Biomarker to Assess Prostate Cancer Cases: Atlantic PATH Cohort Study
This study aimed to characterize arsenic species and metallome profiles in toenails and urine samples, compare these profiles between prostate cancer cases and controls, and evaluate the utility of toenail and urine biomarkers. Toenails were found to be viable biomarkers for altered arsenic speciation in prostate cancer cases.
Substituting bouts of sedentary behavior with physical activity: adopting positive lifestyle choices in people with a history of cancer
This study aimed to determine the association between substituting sitting time with other daily activities and changes in waist circumference amongst people with cancer history. The researchers found that small changes to minimize their sitting time help reduce waist circumference, possibly offsetting other adverse health outcomes.
Applying Machine Learning to Arsenic Species and Metallomics Profiles of Toenails to Evaluate Associations of Environmental Arsenic with Incident Cancer Cases
This preliminary study aimed to understand the association between environmental metal pathogenicity and carcinogenicity and prostate cancer. Researchers used toenails to capture arsenic exposure!
Analysis of human serum and urine for tentative identification of potentially carcinogenic pesticide-associated N-nitroso compounds using high-resolution mass spectrometry
Using data from 64 Atlantic PATH participants, this study marks the first biomonitoring investigation of PANN compounds in human serum and urine. A majority of the participants were found to have been exposed to some nitrosatable pesticides and potentially carcinogenic PANN compounds.
Lifestyle factors and lung cancer risk among never smokers in the Canadian Partnership for Tomorrow’s Health (CanPath)
Data from 950 CanPath participants were analyzed to understand why 15-25% of lung cancers occur in never smokers. Researchers found a link between lung cancer risk, sleep, and fruit and vegetable intake amongst never smokers.