Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2022

A dietary carbohydrate – gut Parasutterella – human fatty acid biosynthesis metabolic axis in obesity and type 2 diabetes

Authors: Lea Henneke, Kristina Schlicht, Nadia A. Andreani, Tim Hollstein, Tobias Demetrowitsch, Carina Knappe, Katharina Hartmann, Julia Jensen-Kroll, Nathalie Rohmann, Daniela Pohlschneider, Corinna Geisler, Dominik M. Schulte, Ute Settgast, Kathrin Türk, Johannes Zimmermann, Christoph Kaleta, John F. Baines, Jane Shearer, Shrushti Shah, Grace Shen-Tu, Karin Schwarz, Andre Franke, Stefan Schreiber, Matthias Laudes

This study aimed to characterize Parasutterella, a gut bacteria, in a European cohort. 438 participants from Alberta’s Tomorrow Project were included to validate the results of this study. Researchers found that this bacteria have a role in type 2 diabetes and obesity.

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2022

Health-Related and Behavioral Factors Associated With Lung Cancer Stage at Diagnosis: Observations From Alberta’s Tomorrow Project

Authors: Michelle L. Aktary, Monica Ghebrial, Qinggang Wang, Lorraine Shack, Paula J. Robson, Karen A. Kopciuk

This study examined sociodemographic characteristics and health-related factors and their associations with subsequent lung cancer stage at diagnosis. Using data from 221 Alberta’s Tomorrow Project participants, researchers found that a history of sunburn in the past year and more prostate-specific antigen tests were protective against late-stage lung cancer diagnosis, whereas physical activity increased late-stage cancer diagnosis odds.

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2022

Pre-diagnosis lifestyle, health history and psychosocial factors associated with stage at breast cancer diagnosis – Potential targets to shift stage earlier

Authors: Qinggang Wang, Michelle L. Aktary, John J. Spinelli, Lorraine Shack, Paula J.Robson, Karen A. Kopciuk

This study aimed to examine associations between risk factors for breast cancer diagnosis, prior to and and at diagnosis. Some protective factors include older age at diagnosis, high household income, parity, smoking, spending time in the sun (high ultraviolet), having a mammogram, and high daily protein intake. Factors that increase risk of later stage at diagnosis include comorbidities, stressful situations, and high daily caloric intake.

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2022

Lifestyle factors and lung cancer risk among never smokers in the Canadian Partnership for Tomorrow’s Health (CanPath)

Authors: Rachel Murphy, Maryam Darvishian, Jia Qi, Yixian Chen, Quincy Chu, Jennifer Vena, Trevor J B Dummer, Nhu Le, Ellen Sweeney, Vanessa DeClercq, Scott A Grandy, Melanie R Keats, Yunsong Cui, Philip Awadalla, Darren R Brenner, Parveen Bhatti

Data from 950 CanPath participants were analyzed to understand why 15-25% of lung cancers occur in never smokers. Researchers found a link between lung cancer risk, sleep, and fruit and vegetable intake amongst never smokers.

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2022

Evaluation of Adiposity and Cognitive Function in Adults

Authors: Sonia S. Anand, Matthias G. Friedrich, Douglas S. Lee, Phillip Awadalla, J. P. Després, Dipika Desai, Russell J. de Souza, Trevor Dummer, Grace Parraga, Eric Larose, Scott A. Lear, Koon K. Teo, Paul Poirier, Karleen M. Schulze, Dorota Szczesniak, Jean-Claude Tardif, Jennifer Vena, Katarzyna Zatonska, Salim Yusuf, Eric E. Smith, the Canadian Alliance of Healthy Hearts and Minds (CAHHM), the Prospective Urban and Rural Epidemiological (PURE) Study Investigators

Researchers sought to undercover the association between adipose tissue (amount and distribution) and cognitive scores. Using data from 9,189 participants, they found that higher visceral adipose tissue and body fat percentage correlated with increased vascular brain injuries and cardiovascular risk factors, as well as lower cognitive scores.

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2021

Predictors of CRC Stage at Diagnosis among Male and Female Adults Participating in a Prospective Cohort Study: Findings from Alberta’s Tomorrow Project

Authors: Monica Ghebrial, Michelle L. Aktary, Qinggang Wang, John J. Spinelli, Lorraine Shack, Paula J. Robson, Karen A. Kopciuk

This study aimed to uncover factors associated with colorectal cancer (CRC) at diagnosis in 267 Alberta Tomorrow Project participants. Researchers found that social support, having children, and caffeine intake were strong CRC stage predictors at diagnosis for males. In contrast, CRC family history, pregnancy, hysterectomy, menopausal hormone therapy, Pap test lifetime number, and household physical activity were strong CRC predictors at diagnosis for females.

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2021

Chronic Disease Surveillance in Alberta’s Tomorrow Project using Administrative Health Data

Authors: Ming Ye, Jennifer Vena, Jeffrey Johnson, Grace Shen-Tu, Dean Eurich

This study linked data from 52,770 Alberta’s Tomorrow Project participants with Alberta Health data to describe the prevalence and incidence of chronic diseases. Researchers found an increase in chronic diseases among the cohort, especially for cardiovascular diseases and multimorbidity.

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2021

Associations between neighbourhood built characteristics and sedentary behaviours among Canadian men and women: findings from Alberta’s Tomorrow Project

Authors: Vikram Nichani, Liam Turley, Jennifer E. Vena, Gavin R. McCormack

This study examined associations between the objective neighbourhood built environment and self-reported sedentary behaviour. Researchers sourced data from 14,785 Alberta’s Tomorrow Project participants. 3-way intersections, high population counts, and high walkability resulted in more sitting time, and low connectivity and low walkability resulted in more sitting time in motor vehicles.

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2021

The effect of different methods to identify, and scenarios used to address energy intake misestimation on dietary patterns derived by cluster analysis

Authors: Geraldine Lo Siou, Alianu Akawung, Nathan Solbak, Kathryn McDonald, Ala Al Rajabi, Heather Whelan, Sharon Kirkpatrick

This study used self-reported food frequency and physical activity data from Alberta’s Tomorrow Project participants to compare the revised-Goldberg and the predicted total energy expenditure methods in their ability to identify misreporters of energy intake.

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2021

Towards refining World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations for red and processed meat intake: insights from Alberta’s Tomorrow Project cohort

Authors: Ala Al Rajabi, Geraldine Lo Siou, Alianu K. Akawung, Kathryn McDonald, Tiffany R. Price, Grace Shen-Tu, Paula J. Robson, Paul J. Veugelers, Katerina Maximova

This study examined the associations of processed meat derived from red versus non-red meats with cancer risk in the Alberta’s Tomorrow Project cohort of 26 218 adults who reported dietary intake using the Canadian Diet History Questionnaire. Incidence of cancer was obtained through data linkage with the Alberta Cancer Registry.

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