Publications

Les publications qui suivent sont des exemples de recherches rendues possibles grâce aux données de CanPath et de ses cohortes régionales.

2025

Provincial variation in colorectal cancer screening adherence in Canada; evidence from the Canadian Partnership for Tomorrow’s Health

Auteurs : M. Darvishian, A. Moustaqim-Barrette, P. Awadalla, P. Bhatti, P. Broet, R. A. Murphy, K. Skead, R. Urquhart, J. Vena, T. J. B. Dummer.

The researchers investigated how social and medical characteristics influence adherence to breast cancer screening in Canada. They used data from five regional cohorts of the Canadian Partnership for Tomorrow’s Health (CanPath): the BC Generations Project (BCGP), Alberta’s Tomorrow Project (ATP), the Ontario Health Study (OHS), Quebec’s CARTaGENE, and the Atlantic Partnership for Tomorrow’s Health Study (Atlantic PATH). They analyzed self-reported data on screening mammography among 79,986 participants aged 50-74 and 46,907 participants aged 40-49. Most participants reported undergoing screening within two years of enrollment, with rates ranging from 77.8% in OHS to 86.3% in BCGP. Factors linked to lower odds of screening included lower household income, being single or never married, current daily smoking, poor self-perceived health, no history of breastfeeding, and longer intervals since the last routine medical check-up. Among women aged 40-49 with a first-degree family history of breast cancer, screening adherence varied by region and was lower among those post-menopause or with longer intervals since medical check-ups. These findings highlight key factors for targeting underserved communities and suggest that early screening guidelines may benefit from considering regional differences and individual health characteristics.

Lire la publication
2025

Quality of non-surgical and non-pharmacological knee osteoarthritis care in the Maritimes

Auteurs : A. R. Budarick, C. L. Hubley-Kozey, L. C. Li, O.Theou, W. D. Stanish, R.F. Moyer

The researchers evaluated the quality of care for individuals with mild-to-moderate knee osteoarthritis recruited from the Atlantic PATH cohort in the Canadian Maritime provinces. Using a healthcare quality survey based on the British Columbia Osteoarthritis criteria, they found an overall pass rate of 42.9%, with only 4.3% receiving non-ambulatory function assessments compared to 85.7% for ambulatory function assessments. These findings underscore significant gaps in care for individuals with mild-to-moderate knee osteoarthritis in the Maritimes.

Lire la publication
2025

Covert vascular brain injury and cognitive dysfunction among Chinese adults living in Canada and China

Auteurs : C. Ke, S.S. Anand, E.E. Smith , K.M. Schulze, A. Moody

The researchers examined how country of residence influences covert cerebrovascular disease (VBI) and cognitive dysfunction among Chinese adults living in Canada and China. The study compared Chinese adults in Canada and China. They found that people in Canada had a lower prevalence of covert VBI and cognitive dysfunction than those living in China, even though both groups shared the same ethnicity. Living in China was associated with a much higher risk of covert VBI and lower cognitive function, although the link between cognitive dysfunction and country of residence was explained by education and traditional cerebrovascular risk factors, such as blood pressure and cholesterol.

Lire la publication
2024

Investigating Skin Cancer Risk and Sun Safety Practices Among LGBTQ+ Communities in Canada

Auteurs : F. Lagacé, F. Mahmood, S. Conte, L. A. Mija, A. Moustaqim-Barrette, J. LeBeau, A. McKenna, M. Maazi, J. Hanna, A. S. V. Kelly, R. Lazarowitz, E. Rahme, T. J. Hrubeniuk, E. Sweeney, I. V. Litvinov,

The researchers conducted a national survey of 700 LGBTQ+ individuals to evaluate skin cancer risk factors, sun-protective behaviors, and related concerns. Some participants were recruited with the help of longitudinal cohorts, notably the Manitoba Tomorrow Project and Atlantic PATH. The researchers found that 60% reported over 10 lifetime sunburns, 58% experienced at least one blistering sunburn, 34% had used tanning beds, and 69% reported having a tan in the last 12 months. Regular sunscreen use was reported by only half of the respondents. These findings emphasize the urgent need for culturally sensitive public health campaigns targeting sun safety practices within the LGBTQ+ community.

Lire la publication
2024

Exposure to air pollutants and subclinical carotid atherosclerosis measured by magnetic resonance imaging: A cross-sectional analysis

Auteurs : S. M. Azab, D. Doiron, K. M. Schulze, J. R. Brook, M. Brauer, E. E. Smith, A. R. Moody, D. Desai, M. G. Friedrich, S. I. Bangdiwala, D. Zeraatkar, D. Lee, T. J. B. Dummer, P. Poirier, J.-C. Tardif, K. K. Teo, S. Lear, S. Yusuf, S. S. Anand, R. J. de Souza.

The researchers examined how long-term exposure to air pollution affects early signs of heart disease. They used data to explore whether low levels of air pollutants are linked to the thickening of artery walls. The study included 6,645 adults from five Canadian provinces and estimated their exposure to nitrogen dioxide (NO₂), ozone (O₃), and fine particulate matter (PM2.5) over several years. Using MRI scans to measure carotid artery wall thickness, the researchers found mixed results. Higher levels of ozone were linked to thicker artery walls, suggesting a potential negative effect, while higher nitrogen dioxide levels were associated with thinner artery walls, a finding that requires further investigation.

Lire la publication
2024

Investigating the genetic architecture of eye colour in a Canadian cohort

Auteurs : F.Lona-Durazo, R.Thakur, E. Pairo-Castineira, K. Funderburk, T. Zhang, M. A. Kovacs, J. Choi, I. J. Jackson, K. M. Brown, E. J. Parra

Researchers used data from 5,641 participants of European ancestry from the Canadian Partnership for Tomorrow’s Health (CanPath) and performed genome-wide association studies to investigate the genetic basis of eye color. The study identified multiple independent candidate causal variants in the HERC2/OCA2 region, along with single candidate variants near other genes such as IRF4, SLC24A4, TYR, and TYRP1. These findings suggest that eye color variation is influenced by specific molecular processes in iris melanocytes.

Lire la publication
2024

The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: An individual participant data meta-analysis

Auteurs : Kuan-Yu Pan, Lonneke van Tuijl , Maartje Basten, Judith J M Rijnhart, Alexander de Graeff, Joost Dekker , Mirjam I Geerlings, Adriaan Hoogendoorn, Adelita V Ranchor, Roel Vermeulen, Lützen Portengen, Adri C Voogd, Jessica Abell, Philip Awadalla, Aartjan T F Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Monika Hollander, Martijn Huisman, Anke Huss, Melanie R Keats, Almar A L Kok, Steinar Krokstad, Flora E van Leeuwen, Annemarie I Luik, Nolwenn Noisel, Yves Payette, Brenda W J H Penninx , Susan Picavet, Ina Rissanen, Annelieke M Roest, Judith G M Rosmalen, Rikje Ruiter, Robert A Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R Sund, Ellen Sweeney, Alison Teyhan, Emma L Twait, Kimberly D van der Willik, Femke Lamers

Researchers investigated how various health behaviors might mediate the relationships between depression, anxiety, and the onset of different types of cancer. They conducted individual participant data meta-analyses using participants from 18 cohorts from the Psychosocial Factors and Cancer Incidence consortium.The cohorts analyzed included the Atlantic Partnership for Tomorrow’s Health, Ontario Health Study, and CARTaGENE. The findings suggested that smoking serves as a mediating factor that connects depression and anxiety with lung cancer and other cancers related to smoking.

Lire la publication
2024

Oral microbial signatures associated with age and frailty in Canadian adults

Auteurs : V. DeClercq, R. Wright, J. Nearing, M. Langille

The researchers investigated the relationship between the oral microbiome, age, and frailty using data from Atlantic PATH cohort participants. Analyzing saliva samples from 1,357 individuals aged 35–70, they found that frailty was inversely associated with most alpha diversity measures, while age was positively associated with Shannon Diversity and Evenness. These findings suggest that the oral microbiome may be a valuable marker of frailty risk and a potential target for health interventions in aging adults.

Lire la publication
2024

Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Auteurs : Maartje Basten, Kuan-Yu Pan, Lonneke A vanTuijl, Alexander de Graeff, Joost Dekker, Adriaan W Hoogendoorn, Femke Lamers, Adelita V Ranchor, Roel Vermeulen, Lützen Portengen, Adri C Voogd, Jessica Abell, Philip Awadalla, Aartjan T.F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Melanie R. Keats, Almar A.L. Kok, Steinar Krokstad, Flora E. van Leeuwen, Annemarie I. Luik, NolwennNoisel, Yves Payette, Brenda W.J.H. Penninx, Ina Rissanen, Annelieke M. Roest, Judith G.M. Rosmalen, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Emma L. Twait, Alison Teyhan, W.M. Monique Verschuren, Kimberly D. van der Willik, Mirjam I. Geerlings

Researchers determined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Data were used from 22 cohorts, including the Ontario Health Study, Atlantic Partnership for Tomorrow’s Health, and CARTaGENE. After exploring 744 combinations of psychosocial factors, the researchers found no evidence that psychosocial factors interacted with or modified health behaviors related to cancer incidence.

Lire la publication
2023

Factors associated with change in moderate or severe symptoms of anxiety and depression in community-living adults and older adults during the COVID-19 pandemic

Auteurs : Helen-Maria Vasiliadis, Jessica Spagnolo, Mary Bartram, Marie-Josée Fleury, Jean-Philippe Gouin, Sébastien Grenier, Pasquale Roberge, Grace Shen-Tu, Jennifer E Vena, Catherine Lamoureux-Lamarche , JianLi Wang

Researchers explored changes in moderate or severe symptoms of anxiety or depression (MSSANXDEP) from before to during the COVID-19 pandemic in Canada, and examined associated sociodemographic, economic, psychosocial, health behavior and lifestyle, and clinical factors. Data from 59,997 participants from the five established cohorts of the Canadian Partnership for Tomorrow’s Health (CanPath) were used. Analyses indicated that certain sociodemographic, economic, lifestyle, health behavior, psychosocial, and clinical factors were associated with remitted, incident, and persistent MSSANXDEP.

Lire la publication