Evaluation of Adiposity and Cognitive Function in Adults
Researchers sought to undercover the association between adipose tissue (amount and distribution) and cognitive scores. Using data from 9,189 participants, they found that higher visceral adipose tissue and body fat percentage correlated with increased vascular brain injuries and cardiovascular risk factors, as well as lower cognitive scores.
Predictors of CRC Stage at Diagnosis among Male and Female Adults Participating in a Prospective Cohort Study: Findings from Alberta’s Tomorrow Project
This study aimed to uncover factors associated with colorectal cancer (CRC) at diagnosis in 267 Alberta Tomorrow Project participants. Researchers found that social support, having children, and caffeine intake were strong CRC stage predictors at diagnosis for males. In contrast, CRC family history, pregnancy, hysterectomy, menopausal hormone therapy, Pap test lifetime number, and household physical activity were strong CRC predictors at diagnosis for females.
A large Canadian cohort provides insights into the genetic architecture of human hair colour
Researchers performed genome-wide association studies and meta-analyses to garner insight on regulatory mechanisms of hair colour variation and pigmentation biology. 12,996 genotyped CanPath participants were included in this study, along with their self-reported natural hair colour. The researchers fine-mapped significant loci throughout the genome, identifying multiple novel causal variants for hair colour.
Chronic Disease Surveillance in Alberta’s Tomorrow Project using Administrative Health Data
This study linked data from 52,770 Alberta’s Tomorrow Project participants with Alberta Health data to describe the prevalence and incidence of chronic diseases. Researchers found an increase in chronic diseases among the cohort, especially for cardiovascular diseases and multimorbidity.
Effect of Cognitive Reserve on the Association of Vascular Brain Injury with Cognition: Analysis of the PURE and CAHHM Studies
This study sought to determine whether cognitive reserve lessens the correlation between brain injury and cognition. The researchers analyzed data from two population-based studies, including the Canadian Alliance for Healthy Hearts and Healthy Minds (CAHHM), comprising CanPath national and regional data. They found that brain injury and cognitive reserve are related to cognition, but higher cognitive reserve does not mitigate the harmful effects of brain injury.
Two approaches for estimating propensity score weights for examining neighbourhood built environment and walking changes
Christie et al. created a walkability index using pre- and post-relocation neighbourhood built environment and walking data from Alberta’s Tomorrow Project participants to examine how walking duration changed with residential relocation. While changes in walkability were not associated with changes in walking, the researchers suggest further research regarding neighbourhood environment changes and other physical activity behaviours.
Examining the etiology of early-onset breast cancer in the Canadian Partnership for Tomorrow’s Health (CanPath)
The objective of this study was to investigate relationships between modifiable and non-modifiable risk factors and early-onset breast cancer among the BC Generations Project, Alberta’s Tomorrow Project and Ontario Health Study. In this study, measures of adiposity, pregnancy history, and familial history of breast cancer are important risk factors for early-onset breast cancer.
Dietary patterns with combined and site-specific cancer incidence in Alberta’s Tomorrow Project cohort
This study used data from the Alberta’s Tomorrow Project to examine the association between dietary patterns derived with two methods, and combined and site-specific cancer incidence in Canada.
Associations between neighbourhood built characteristics and sedentary behaviours among Canadian men and women: findings from Alberta’s Tomorrow Project
This study examined associations between the objective neighbourhood built environment and self-reported sedentary behaviour. Researchers sourced data from 14,785 Alberta’s Tomorrow Project participants. 3-way intersections, high population counts, and high walkability resulted in more sitting time, and low connectivity and low walkability resulted in more sitting time in motor vehicles.
The effect of different methods to identify, and scenarios used to address energy intake misestimation on dietary patterns derived by cluster analysis
This study used self-reported food frequency and physical activity data from Alberta’s Tomorrow Project participants to compare the revised-Goldberg and the predicted total energy expenditure methods in their ability to identify misreporters of energy intake.