Linking Canadian Population Health Data: Maximizing the Potential of Cohort and Administrative Data
Linking data collected by large cohort studies would afford ways for great research to advance and get information about disease. This article affirms that the cohorts are aware of the challenges involved, and are committed to working hard with stakeholders.
Prevalence of meeting physical activity guidelines for cancer prevention in Alberta
They looked at the guidelines for physical activity of 14294 particpants between the ages of 35-64 and found 23-55% of participants met the guidelines, depending on which one they were being measured against (CSEP, ACS, USDHHS, WCRF/AICR). Women were less likely to reach certain guidelines than men were. Study concluded that people in Alberta, mostly women were not active enough for cancer prevention benefits.
A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility
This study looked at a two-stage association design using markers from a genome-wide study. They restricted their analysis to DNA polymorphisms and selected 22 SNPS. There were certain SNPs that were found to be relevant to breast cancer susceptibility in populations.
Hours spent and energy expended in physical activity domains: Results from The Tomorrow Projectcohort in Alberta, Canada
A survey called Past Year Total Physical Activity Questionnaire had 15591 participants that dealt with the amount of phyiscal activity each person got. Those who were considered inactive got most of their activty at work. One suggestion was that environmental and policy changes could be amended so that more energy could be expended, and there would be less sitting time.
From consent to institutions: Designing adaptive governance for genomic biobanks
This paper outlined four principles regarding biobank governance: 1) recognizing participants as one entity 2) integrity 3) adaptive management 4) fit between the nature of a particular biobank and the specific structural elements of governance adopted. BC Generations was a working model for further discussion the outlines of the proposed governance.
Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility
They performed a two-stage association study with a cohort of 3064 women . They did two various stages of the study. Stage I was looking at single nucleotide polymorphisms and Stage II was replicating specific markers from stage I. After doing the two stages they were able to identify various genetic regions and the SNPs discssed could serve as a potential candidate loci for breast cancer in another replication study.
Exploring Statistical Approaches to Diminish Subjectivity of Cluster Analysis to Derive Dietary Patterns: The Tomorrow Project
The reseachers wanted to explore dietary patterns, so they did a food frequency questionnaire of 6445 men and 10299 women. An analysis was done which looked at proteins, fats, and calories and the information was compiled using a clustering method.
Access Arrangements’ for Biobanks: A Fine Line between Facilitating and Hindering Collaboration
This paper looked at how access arrangements identify key elements of these new regulatory instruments. It also looks at the different ways biobanks regulate access and surveys, it also outlines the challenges involved with creating access policy with CARTaGENE.
Cohorts and consortia conference: a summary report (Banff, Canada, June 17–19, 2009)
This discussed how various cohort studies can build a strong network of research.
The Canadian Partnership for Tomorrow Project: building a pan-Canadian research platform for disease prevention
This article outlines the challenges a pan-Canadian cohort to look at cancer and chronic disease. The hope of this cohort will be that it could be a major research platform for the study of disease causation nationally, and internationally. They outlined how they got their participants, which provinces are involved, and how this specific cohort is unique.