Heart rate dependent and independent effects of beta-blockers on central hemodynamic parameters: a propensity score analysis
In this article they looked the association between beta-blocker use, heart rate, and central hemodynamics in hypertensive CARTaGENE participants. They looked at 20004 people and determined that there were unfavourable central hemodynamic profile of beta-blocker has both HR-dependent and HR-indepdent components that are similar for all frequency used beta1 selective blocker.
Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion.
This study observed excretion of uromodulin and variations in the UMOD gene. Those with higher levels of uromodulin also had higher levels of uric acid, sodium in their bodies
G1 Gene-environment-lifestyle factors in breast cancer susceptibility: machine learning tools to build predictive models
This study hoped to build predictive models for personalized breast screening. They were able to develop good predictive models for etiologies that would cause disease, and hope their model will aid in preventing breast cancer.
Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis
In this study, they looked at mutations of MATR3 (gene that is associated with ALS). They assessed the frequency in French Canadian populations and had a control group. They were able to determine which proteins are associated with ALS.
Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross‐Sectional Analysis Among Nondiabetic Patients
This study used CARTaGENE data to determine to assess the noninferority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. No major differences were noted and it was shown that TDs are at least as effective as other first line medications that are available.
Neighborhood greenspace and health in a large urban center
This study focused on self-reported mental health study looked at the density of trees/green spaces in various neighbourhoods in Toronto. Those that had more trees reported that they were happier and felt better about their mental health.
Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris
It was found that in a study of 20,000 people our results showed that the prevalence of angina was 3 times more in iciHHV-6+ people than those who did not have a copy of the virus. It also showed that iciHHV-6+ may contribute to the development of angina.
Are Physical Activity Levels Linked to Nutrient Adequacy? Implications for Cancer Risk
This study showed that higher PAL would promote better health and have DRIs which would help promote potential cancer-preventing nutrients. Benefits of higher PAIs may extend beyond the usual benefits attributed to physical activity.
Recombination affects accumulation of damaging and disease-associated mutations in human populations
Using high-coverage sequencing data from over 1,400 individuals in the 1000 Genomes and CARTaGENE projects, we show that recombination rate modulates the distribution of putatively deleterious variants across the entire human genome.
Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals
They wanted to determine if there was an association with height, arterial stiffness, and bone fractures. They were able to determine at the end of the study that those with shorter statures were more likely to have arterial stiffness and hypertension.