Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2016

Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion.

Authors: Stephan Troyanov, Catherine Delmas-Frenette, Guillaume Bollee, Sonia Youhanna, Vanessa Bruat, Philip Awadalla, Olivier Devuyst, Francois Madore

This study observed excretion of uromodulin and variations in the UMOD gene. Those with higher levels of uromodulin also had higher levels of uric acid, sodium in their bodies

Read Publication
2015

G1 Gene-environment-lifestyle factors in breast cancer susceptibility: machine learning tools to build predictive models

Authors: Jay Patel, Nasimeh Asgarian, Paula Robson, Russ Greiner, John Mackey, Sambasivarao Damaraju

This study hoped to build predictive models for personalized breast screening. They were able to develop good predictive models for etiologies that would cause disease, and hope their model will aid in preventing breast cancer.

Read Publication
2015

Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis

Authors: Claire Leblond, Ziv Gan-Or, Dan Spiegelman, Sandra Laurent, Anna Szuto, Alan Hodgkinson, Alexandre Dionne-Laporte, Pierre Provencher, Mamde de Carvalho, Sandro Orru, Denis Brunet, Jean-Pierre Bouchard, Philip Awadalla, Nicholas Dupre, Patrick Dion, Guy Rouleau

In this study, they looked at mutations of MATR3 (gene that is associated with ALS). They assessed the frequency in French Canadian populations and had a control group. They were able to determine which proteins are associated with ALS.

Read Publication
2015

Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross‐Sectional Analysis Among Nondiabetic Patients

Authors: Cristiano S. Moura, Stella S. Daskalopoulou, Linda E. Levesque, Sasha Bernatsky, Michal Abrahamowicz, Meytal A. Tsadok, Shadi Rajabi, Louise Pilote

This study used CARTaGENE data to determine to assess the noninferority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. No major differences were noted and it was shown that TDs are at least as effective as other first line medications that are available.

Read Publication
2015

Neighborhood greenspace and health in a large urban center

Authors: Omid Kardan, Peter Gozdyra, Bratislav Misic, Faisal Moola, Lyle J. Palmer, Tomáš Paus & Marc G. Berman

This study focused on self-reported mental health study looked at the density of trees/green spaces in various neighbourhoods in Toronto. Those that had more trees reported that they were happier and felt better about their mental health.

Read Publication
2015

Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris

Authors: Annie Gravel, Isabelle Dubuc, Guillaum Morissette, Ruth Sedlak, Keith Jerome, Louis Flamand

It was found that in a study of 20,000 people our results showed that the prevalence of angina was 3 times more in iciHHV-6+ people than those who did not have a copy of the virus. It also showed that iciHHV-6+ may contribute to the development of angina.

Read Publication
2015

Are Physical Activity Levels Linked to Nutrient Adequacy? Implications for Cancer Risk

Authors: I Cszimadi, LE Kelemen, T Speidel, Y Yuan, LC Dale, CM Friedenreich, PJ Robson

This study showed that higher PAL would promote better health and have DRIs which would help promote potential cancer-preventing nutrients. Benefits of higher PAIs may extend beyond the usual benefits attributed to physical activity.

Read Publication
2015

Recombination affects accumulation of damaging and disease-associated mutations in human populations

Authors: Julie G Hussin, Alan Hodgkinson, Youssef Idaghdour, Jean-Christophe Grenier, Jean-Philippe Goulet, Elias Gbeha, Elodie Hip-Ki & Philip Awadalla

Using high-coverage sequencing data from over 1,400 individuals in the 1000 Genomes and CARTaGENE projects, we show that recombination rate modulates the distribution of putatively deleterious variants across the entire human genome.

Read Publication
2015

Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals

Authors: Rana EL-Bikai, Muhammad Tahir, Johanne Tremblay, Michel Joffres, Ondřej Šeda, Lucie Šedová, Philip Awadalla, Claude Laberge, Bartha-Maria Knoppers, Pierre Dumas, Daniel Gaudet, Louis-Georges Ste-Marie, Pavel Hamet

They wanted to determine if there was an association with height, arterial stiffness, and bone fractures. They were able to determine at the end of the study that those with shorter statures were more likely to have arterial stiffness and hypertension.

Read Publication
2015

Leisure-Time Physical Activity Does not Attenuate the Association Between Occupational Sedentary Behavior and Obesity: Results From Alberta’s Tomorrow Project.

Authors: Joshua Nicholas, Geraldine Lo Siou, Brigid Lynch, Paula Robson, Christine Friedenrich, and Ilona Csizmadi

Using ATP data, this study determined that those in sedendary jobs are more at higher risk of obesity and was not attenuated by physical activity. Women did not show the same risk with sedendary behaviour.

Read Publication