Metabolic profiling of adherence to diet, physical activity and body size recommendations for cancer prevention
This study examined cross-sectional associations between metabolites and cancer preventive behaviors as well as the relevance to cancer-related pathways among 120 participants with no history of smoking or cancer. Cancer preventive behaviors were associated with complex metabolic signatures, including alterations in pathways known to be involved in cancer pathogenesis.
Cohort Profile: The British Columbia Generations Project (BCGP)
29850 people in BC were surveyed between the ages of 35-69. Information such as health and lifestyle, physical measurements, biosamples, and genotyping were done.
Physical Activity and Cancer Incidence in Alberta’s Tomorrow Project: Results from a Prospective Cohort of 26,538 Participants.
They were able to determine that a moderate to high level of physical activity could lead to a modest protection against the development of all cancer.
Plasma-Derived Inflammatory Proteins Predict Oral Squamous Cell Carcinoma
This study looked at a multiplex approach to screen plasma derived biomarkers and to examine the association of proteins with throat cancer. They looked at 260 plasma samples and they screened 82 biomarkers to look for disease.
Lead in drinking water: a response from the Atlantic PATH study
Most of the people who were being observed in this study were below the maximum level for lead intake, however the few that were the outliners are still cause for concern.
Atopic dermatitis and risk of hypertension, type 2 diabetes, myocardial infarction and stroke in a cross‐sectional analysis from the Canadian Partnership for Tomorrow Project
This study wanted to determine if there was an association with atopic dermatitis and hypertension/heart attack/stroke/type II diabetes. It was found in a cross-sectional study that AD is not really a major risk factor for cardiovascular disease.
Allele-specific expression reveals interactions between genetic variation and environment
Combining whole-blood RNA-seq with extensive environmental annotations collected from 922 human individuals, we identified 35 GxE interactions, compared with only four using standard GxE interaction testing. EAGLE provides new opportunities for researchers to identify GxE interactions using functional genomic data.
Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis
The objective was for the researchers to see the relationship between adipokines and adiposity in individuals with rheumatoid/osteoarthritis. There were no statistical differences between levels of plasma adipokines; adiponectin levels were 6.6, 7.9, and 8.2 μg/ml, leptin levels were 10.3, 13.7, and 11.5 ng/ml, and resistin levels were 10.0, 12.1, and 10.8 ng/ml in participants without arthritis, with rheumatoid arthritis, and with osteoarthritis, respectively.
Impact of the X Chromosome and sex on regulatory variation
The research team analyzed blood transcriptomes of 922 individuals and they were able to conduct the first large-scale genome wide analysis of sex/genetic variation patterns. They generated chromatin and were able to develop genome-wide insight into how genetic variation shape human gene regulation and disease.
Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals
They wanted to determine if there was an association with height, arterial stiffness, and bone fractures. They were able to determine at the end of the study that those with shorter statures were more likely to have arterial stiffness and hypertension.