Plasma-Derived Inflammatory Proteins Predict Oral Squamous Cell Carcinoma
This study looked at a multiplex approach to screen plasma derived biomarkers and to examine the association of proteins with throat cancer. They looked at 260 plasma samples and they screened 82 biomarkers to look for disease.
Lead in drinking water: a response from the Atlantic PATH study
Most of the people who were being observed in this study were below the maximum level for lead intake, however the few that were the outliners are still cause for concern.
Atopic dermatitis and risk of hypertension, type 2 diabetes, myocardial infarction and stroke in a cross‐sectional analysis from the Canadian Partnership for Tomorrow Project
This study wanted to determine if there was an association with atopic dermatitis and hypertension/heart attack/stroke/type II diabetes. It was found in a cross-sectional study that AD is not really a major risk factor for cardiovascular disease.
Allele-specific expression reveals interactions between genetic variation and environment
Combining whole-blood RNA-seq with extensive environmental annotations collected from 922 human individuals, we identified 35 GxE interactions, compared with only four using standard GxE interaction testing. EAGLE provides new opportunities for researchers to identify GxE interactions using functional genomic data.
Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis
The objective was for the researchers to see the relationship between adipokines and adiposity in individuals with rheumatoid/osteoarthritis. There were no statistical differences between levels of plasma adipokines; adiponectin levels were 6.6, 7.9, and 8.2 μg/ml, leptin levels were 10.3, 13.7, and 11.5 ng/ml, and resistin levels were 10.0, 12.1, and 10.8 ng/ml in participants without arthritis, with rheumatoid arthritis, and with osteoarthritis, respectively.
Impact of the X Chromosome and sex on regulatory variation
The research team analyzed blood transcriptomes of 922 individuals and they were able to conduct the first large-scale genome wide analysis of sex/genetic variation patterns. They generated chromatin and were able to develop genome-wide insight into how genetic variation shape human gene regulation and disease.
Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals
They wanted to determine if there was an association with height, arterial stiffness, and bone fractures. They were able to determine at the end of the study that those with shorter statures were more likely to have arterial stiffness and hypertension.
Understanding the translation of scientific knowledge about arsenic risk exposure among private well water users in Nova Scotia
This article explored the knowledge of arsenic risk exposure among a well users in 5 areas of Nova Scotia assessed to be at risk of arsenic occurrence in groundwater. The risk ranged from low-high and was assessed over time. It was found that more women were at risk, where 71% of affected well-users were women. About 74% had a really good knowledge of the well water. A fair number of these people use their water as their drinking and 33% seemed confident the water was safe to drink.
From consent to institutions: Designing adaptive governance for genomic biobanks
This paper outlined four principles regarding biobank governance: 1) recognizing participants as one entity 2) integrity 3) adaptive management 4) fit between the nature of a particular biobank and the specific structural elements of governance adopted. BC Generations was a working model for further discussion the outlines of the proposed governance.
Cohorts and consortia conference: a summary report (Banff, Canada, June 17–19, 2009)
This discussed how various cohort studies can build a strong network of research.