These publications are examples of research made possible with data from CanPath and its regional cohorts.


Relaxed Selection During a Recent Human Expansion

Authors: Stephan Peischl, Isabelle Dupanloup, Adrien Foucal, Michele Jomphe, Vanessa Bruat, Jean-Christophe Grenier, Alexandre Gouy, K.J. Gilbert, Elias Gbeha, Lars Bosshard, Eloide Hip-Ki, Mawusse Agbessi, Alan Hodgkinson, Helene Vezina, Philip Awadalla

They assessed genealogies of French Canadians going back to the 17th century (over 4000 ascending geneaologies). With comparison of exomic diversity it revealed: i) both new and low-frequency variants are signficantly more deletrious mutations are at higher frequencies in front individuals, ii)equally deleterious mutations are at higher mutations in front individuals, iii) front individuals are two times more likely to be homozygous for rare very deletrious mutations ins europeans.

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