Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2023

Importance of accounting for timing of time-varying exposures in association studies: Hydrochlorothiazide and non-melanoma skin cancer

Authors: Coraline Danieli, Cristiano S Moura, Louise Pilote, Sasha Bernatsky, Michal Abrahamowicz

The researchers used different models to determine how non-melanoma skin cancer (NMSC) risk varies with hydrochlorothiazide (HCTZ) exposure and explored how the results may be contingent on modeling strategies. Data was collected from study participants who were part of the Ontario Health Study cohort. In parametric models considering all exposures, longer duration of past HCTZ use was linked to a higher risk of NMSC, while cumulative dose did not show a consistent association. However, weighted cumulative exposure model results indicated that only exposures occurring 2.5–4 years ago were associated with the current hazard of NMSC.

Read Publication