2025
Uromodulin and risk of upper urinary tract infections: A Mendelian randomization study
The researchers examined whether uromodulin, a protein produced by the kidneys, helps protect against upper urinary tract infections using data from the CARTaGENE cohort and other large datasets. They used a genetic approach called Mendelian randomization. The study included participants with measured urinary uromodulin levels and individuals with or without upper urinary tract infections. Their analysis showed that higher genetically predicted levels of urinary uromodulin were linked to a lower risk of these infections. These findings suggest that uromodulin may play a protective role in preventing upper urinary tract infections.