Publications

Les publications qui suivent sont des exemples de recherches rendues possibles grâce aux données de CanPath et de ses cohortes régionales.

2022

The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors

Auteurs : S. J. Chen, J. Petricca, W. Ye, J. Guan, Y. Zeng, N. Cheng, L. Gong, S. Y. Shen, J. T. Hua, M. Crumbaker, M. Fraser, S. Liu, S. V. Bratman, T. van der Kwast, T. Pugh, A. M. Joshua, D. D. De Carvalho, K. N. Chi, P. Awadalla, G. Ji, F. Feng, A. W. Wyatt, H. H. He.

The researchers investigated how liquid biopsy using cell-free DNA (cfDNA) methylome analysis can provide insights into the biology of metastatic prostate cancer (mPCa). They analyzed plasma DNA methylomes from 60 patients with localized prostate cancer and 175 patients with metastatic disease. Their findings revealed global hypermethylation in metastatic samples, accompanied by hypomethylation in pericentromeric regions. The authors suggest that liquid biopsy offers a minimally invasive and accurate approach to assess disease progression and potential therapeutic targets in prostate cancer.

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