Publications

Les publications qui suivent sont des exemples de recherches rendues possibles grâce aux données de CanPath et de ses cohortes régionales.

2023

Multivariate extension of penalized regression on summary statistics to construct polygenic risk scores for correlated traits

Auteurs : Meriem Bahda, Jasmin Ricard, Simon L. Girard, Michel Maziade, Maripier Isabelle, Alexandre Bureau

The authors developed a summary-statistics-based multivariate penalized regression approach to improve the prediction of complex human traits and disorders, such as schizophrenia and bipolar disorder, by considering genetic correlations between these conditions. The study utilized genotypes from 29,330 subjects from the CARTaGENE cohort to determine the predictive performance of polygenic risk scores (PRS) for genetically correlated traits in simulation for several PRS construction methods.

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