Publications

These publications are examples of research made possible with data from CanPath and its regional cohorts.

2019

Green space associations with mental health and cognitive function

Authors: Perry Hystad, Yves Payette, Nolwenn Noisel, Catherine Bolieau

This study was done so that they could determine the relationship between mental health and access to green space. They enrolled 8144 people and used questionnares to measure any depression/anxiety. They found that while urban green space affords a lower depression score, it does not affect cognitive function.

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2018

Uromodulin in a Pathway Between Decreased Renal Urate Excretion and Albuminuria

Authors: Alena Krajcoviechova, Francois-Christophe Marois-Blanchet, Stephan Troyanov, Francois Harvey, Pierre Dumas, Johanne Tremblay, Renata Ciftova, Philip Awadalla, Francois Madore, Pavel Hamet

The study team evaluated the impact of candidate variants in the main urate transporter genes, and also they examined the urumodulin/sodium excretion as mediators of the association between FEUA and uACR. Out of the 737 participants, 593 were observed in the final analysis. They found that there was an association between albuminuria with decreased renal urate excretion may be modified by the transporter SLC2A9.

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2018

Environmental health assessment of communities across Canada: contextual factors study of the Canadian Alliance for Healthy Hearts and Minds

Authors: ‪Russell Jude de Souza, Lise Gauvin, Natalie Williams, Scott Lear, A. P. Oliveira, Dipika Desai, Daniel Corsi, SV Subramanian, Ayesha Rana, Rishi Arora, Gillian Booth, Fahad Razak, Jeff Brook, Jack Tu, Sonia S. Anand

This study aimed to report national-level community characteristics and any interprovincial, urban/rural, and Cartesian coordinate differences. Researchers developed an on-line map for public use, showing differences in fruit and vegetable availability, advertising for sweet drinks, junk food, and tobacco products, and cigarette and alcohol prices.

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2018

The Canadian Partnership for Tomorrow Project: a pan-Canadian platform for research on chronic disease prevention

Authors: Trevor J.B. Dummer, Philip Awadalla, Catherine Boileau, Camille Craig, Isabel Fortier, Vivek Goel, Jason M.T. Hicks, Sébastien Jacquemont, Bartha Maria Knoppers, Nhu Le, Treena McDonald, John McLaughlin, Anne-Marie Mes-Masson, Anne-Monique Nuyt, Lyle J. Palmer, Louise Parker, Mark Purdue, Paula J. Robson, John J. Spinelli, David Thompson, Jennifer Vena, Ma’n Zawati

In order to understand the risk factors for disease, participants across the study were recruited across 5 provinces. Body samples and physical information was collected from these people. They then harmonized this data. The hope out of this paper was that the samples afford strides in research both nationally nad internationally.

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2018

Gene-by-environment interactions in urban populations modulate risk phenotypes

Authors: Marie-Julie Favé, Fabien C. Lamaze, David Soave, Alan Hodgkinson, Héloïse Gauvin, Vanessa Bruat, Jean-Christophe Grenier, Elias Gbeha, Kimberly Skead, Audrey Smargiassi, Markey Johnson, Youssef Idaghdour & Philip Awadalla

From ∼1000 individuals of a founder population in Quebec, we reveal a substantial impact of the environment on the transcriptome and clinical endophenotypes, overpowering that of genetic ancestry. Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. 

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2018

Development of an on-line interactive map to display environmental health assessments of Canadian communities: knowledge-translation to support collaborations for health

Authors: Russell Jude de Souza, Rishi Arora, Lise Gauvin, Natalie Williams, A. P. Oliveira, Dipika Desai, Daniel Corsi, SV Subramanian, A. Rana, Gillian Booth, Fahad Razak, Jeff Brook, Jack Tu, Sonia S. Anand

This report describes an on-line interactive map developed by the Canadian Alliance for Healthy Hearts and Minds. It contains information from over 2,000 communities across Canada!

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2018

The author who wasn’t there? Fairness and attribution in publications following access to population biobanks

Authors: Erika Kleiderman, Amy Pack, Pascal Borry, Ma'n Zawati

This study conducted a document analysis that looked at publication ethics and authorship with population biobanks. In their findings, they reported a 3-step approach: 1) the biobank should be given proper acknowledgement 2) co-authorship should be encouraged to foster colloboration amongst researchers 3) referencing/citiations should be readily available

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2018

Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein Cholesterol

Authors: Florence Lamarche, Mohsen Agharazii, Annie-Claire Nadeau-Fredette, Francois Madore, Remi Goupii

This study wanted to characterize the association of stains and LDL-c with central and brachial blood pressures and to quantify their respective effects. They looked 20004 partcipants, and 16507 of them had available central blood pressure. In conclusion, reduction of LDL-c was associated with only a fraction of the lower blood pressures in statin user and seemed to be mostly associated with improvement of steady (diastolic) pressure, whereas non–LDL-c–mediated pathways were mostly associated with changes in pulsatile pressure components.

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2018

Associations Between Depressive Symptoms and Indices of Obesity in Adults With Prediabetes and Normal Blood Glucose Levels: Results From the Emotional Health and Wellbeing Study

Authors: Rachel Burns, Soyna Deschenes, Norbert Schmitz

Depressive symptoms are associated with higher incident rates of dibaetes, but they are not sure if depressive symptoms are linked to prediabetes. The results from this study showed that there was depressive symptoms were positively associated with BMI, fat mass index, waist circumfrence in prediabetic adults. The assoications observed in people with prediabetes were stronger than those observed with normal blood glucose levels.

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2018

The 2017 American College of Cardiology/American Heart Association vs Hypertension Canada High Blood Pressure Guidelines and Potential Implications

Authors: Remi Goupil, Maxime Lamarre-Cliché, Michel Vallee

This report compared the American and Canadian guidelines of Hypertension Canada and American College of Cardiology and American Heart Association and found that compared to the ACC/AHA guidelines it would result in increases of 8.7% in hypertension diagnosis and 3.4% of individuals needing treatment with 17.2% having a different BP target.

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