Dose-responsive effects of iron supplementation on the gut microbiota in middle-aged women
The researchers sought to investigate the association between iron supplementation and the gut microbiota among healthy female participants in Alberta’s Tomorrow Project. They found that adequate iron levels are essential for the overall health and wellbeing of women through their various life stages.
Microbial features linked to medication strategies in cardiometabolic disease management
Researchers explored the association of microbial structure with the use of single or multiple medications among participants from Alberta’s Tomorrow Project who were diagnosed with cardiometabolic disease. Forty-six associations were identified between microbial composition and single medications. Findings indicated that both single- and multiple medication use in cardiometabolic disease is associated with decreases in bacterial diversity, species, and microbial functional potential.
Reduced incidence of diabetes during the COVID-19 pandemic in Alberta: A time-segmented longitudinal study of Alberta’s Tomorrow Project
Researchers aimed to outline the impact of the COVID-19 pandemic on diabetes diagnosis using data from participants who were part of Alberta’s Tomorrow Project. During the COVID-19 pandemic (up to 31 March 2021), the rate of diabetes diagnosis was 32% lower than pre-pandemic levels. The first COVID-19 state of emergency (first wave) was associated with an 87.3% reduction in diabetes diagnoses. This trend continued through the second COVID-19 state of emergency, and no notable increase in diagnoses was observed even after the state of emergency was relaxed. Ultimately, it was found that in Alberta, the COVID-19 public health emergencies had adverse consequences on diabetes diagnoses.
Factors associated with change in moderate or severe symptoms of anxiety and depression in community-living adults and older adults during the COVID-19 pandemic
Researchers explored changes in moderate or severe symptoms of anxiety or depression (MSSANXDEP) from before to during the COVID-19 pandemic in Canada, and examined associated sociodemographic, economic, psychosocial, health behavior and lifestyle, and clinical factors. Data from 59,997 participants from the five established cohorts of the Canadian Partnership for Tomorrow’s Health (CanPath) were used. Analyses indicated that certain sociodemographic, economic, lifestyle, health behavior, psychosocial, and clinical factors were associated with remitted, incident, and persistent MSSANXDEP.
Health-related and psychosocial factors associated with prostate cancer stage at diagnosis among males participating in Alberta’s Tomorrow Project
Researchers investigated the factors associated with the stage at which prostate cancer (PCa) is diagnosed among males in Alberta’s Tomorrow Project. They found that a higher number of lifetime prostate-specific antigen tests were linked to earlier-stage PCa, while higher abdominal circumference, lower social support, and having children were associated with later-stage disease.
Factors associated with mental health service use during the pandemic: Initiation and barriers
This study aimed to understand the factors associated with initiating new mental health service use (MHSU) during the COVID-19 pandemic, as well as distinguishing between different reasons for not seeking mental health services. The research found that several factors influenced MHSU, such as age, living situation, income, and health professional status. The study suggests the need for awareness campaigns targeting older adults to explain the importance of seeking treatment and for sensitizing health professionals to facilitate access to mental health care for individuals at risk of social isolation and lower socioeconomic status.
The evolution of SARS-CoV-2 seroprevalence in Canada: a time-series study, 2020-2023
This study used data from the COVID-19 Immunity Task Force, which includes CanPath data, to track the prevalence of SARS-CoV-2 antibodies in the Canadian population over the pre-vaccination period, the vaccine rollout, and the emergence of the Omicron variant. By March 2023, over three-quarters of the population had detectable antibodies, with the most substantial increases seen after the arrival of the Omicron variant. However, variations in immunity by age and geography highlight the importance of tailoring public health policies and clinical decisions to local patterns of population immunity, considering factors like potential antibody decline and the emergence of new variants that might evade immunity.
Nonfasting remnant cholesterol and cardiovascular disease risk prediction in Albertans: a prospective cohort study
This study aimed to assess the relationship between nonfasting remnant cholesterol and cardiovascular disease (CVD) using data from 13,988 Alberta’s Tomorrow Project participants. The researchers found that nonfasting remnant cholesterol was positively associated with CVD incidence, whereas low-density lipoprotein (LDL) cholesterol was negatively associated with it.
Association of infertility with type and timing of menopause: a prospective cohort study
This study sought to uncover the association between past infertility and type and timing of menopause among midlife women. Using data from 13,243 midlife females from Alberta’s Tomorrow Project, the researchers found that women with past infertility were more likely to experience surgical menopause and had greater risk of earlier surgical menopause until age 43 years but experienced no differences in the timing of natural menopause.
The contributions of neighbourhood design in promoting metabolic health
Using data from 6,718 Alberta’s Tomorrow Project participants, the researchers assessed associations between neighbourhood built environment and metabolic syndrome, or the presence of at least three clinical risk factors among lipid levels, blood pressure, and waist circumference. They found that neighbourhoods with more points of interest and greater overall active living environment-friendliness were associated with fewer metabolic syndrome risk factors and lower odds of metabolic syndrome. Higher dwelling density was also linked to having fewer metabolic syndrome risk factors.