A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility
The study wanted to determine which CNVs (copy number variations) are assoicated with sporadic BC. They also wanted to 2 distinct CNV calling algorithms to identify false positives and finally the aim of the study is identify potential candidate CNVs for follow-up replication studies.
G1 Gene-environment-lifestyle factors in breast cancer susceptibility: machine learning tools to build predictive models
This study hoped to build predictive models for personalized breast screening. They were able to develop good predictive models for etiologies that would cause disease, and hope their model will aid in preventing breast cancer.
Are Physical Activity Levels Linked to Nutrient Adequacy? Implications for Cancer Risk
This study showed that higher PAL would promote better health and have DRIs which would help promote potential cancer-preventing nutrients. Benefits of higher PAIs may extend beyond the usual benefits attributed to physical activity.
Leisure-Time Physical Activity Does not Attenuate the Association Between Occupational Sedentary Behavior and Obesity: Results From Alberta’s Tomorrow Project.
Using ATP data, this study determined that those in sedendary jobs are more at higher risk of obesity and was not attenuated by physical activity. Women did not show the same risk with sedendary behaviour.
The Sedentary Time and Activity Reporting Questionnaire (STAR-Q): reliability and validity against doubly labeled water and 7-day activity diaries.
The research team put together a STAR-Q to estimate past-month energy expenditure. They looked at 102 adults over a two week period. The STAR-Q demonstrated substantial validity for estimating occupational sedentary time and strenuous activity and fair validity for ranking individuals by AEE.
Conditions Associated with Circulating Tumor-Associated Folate Receptor 1 Protein in Healthy Men and Women
This article examined how FOLR1 protein could potentially be way to detect early cancer. The team used electrochemical luminescence immunoassay. The study concluded that they should use caution when saying that serum FOLR1 can detect early cancer as there has not been a study with enough evidence to truly determine that.
Cognitive Testing of the STAR-Q: Insights in Activity and Sedentary Time Reporting
STAR-Q is essentially a questionnare that determines how to assess overall activity/sedendary behaviour. The reason for this study was that they wanted to see how active people are. Participants from the Alberta Tomorrow Project were used.
Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm
The study design also encompassed the 11 variants from GWASs previously reported by various consortia between the years 2007-2009 to (i) enable comparisons of effect sizes, and (ii) identify putative prognostic variants across studies. All SNP associations reported with breast cancer were also adjusted for body mass index (BMI). We report a strong association with 4q31.22-rs1429142 (combined per allele odds ratio and 95% confidence interval = 1.28 [1.17-1.41] and P combined = 1.5×10(-7)), when adjusted for BMI.
Assessing SNP-SNP Interactions among DNA Repair, Modification and Metabolism Related Pathway Genes in Breast Cancer Susceptibility
Our results provide a framework for evaluating SNPs showing statistically weak but reproducible single-locus effects for epistatic effects contributing to disease susceptibility.
ETHNOPRED: a novel machine learning method for accurate continental and sub-continental ancestry identification and population stratification correction
This study looked at ways of getting around the limits of self-declared ancestry, ancestry information markers, genomic control, structured association, and principal component analysis. They found ETHNOPRED to be a good alternative.