Age- and sex-specific associations of frailty with mortality and healthcare utilization in community-dwelling adults from Ontario, Canada
The researchers sought to estimate the association of frailty with the risk of death, hospital admissions, and length of hospital stay. Using data from the Ontario Health Study linked to all-cause mortality and hospital admissions data from ICES, they found that frailty is an important health construct for both younger and older adults.
Population-Based Recalibration of the Framingham Risk Score and Pooled Cohort Equations
Le score de risque de Framingham (FRS) et les équations de cohorte regroupées (ECR) surestiment le risque dans de nombreuses cohortes contemporaines. Cette étude visait à déterminer si le recalibrage de ces scores à l’aide de données contemporaines au niveau de la population améliore la stratification du risque des traitements aux statines.
Long-term exposure to air pollution and mortality in a prospective cohort: The Ontario Health Study
The researchers investigated the association between long-term exposure to air pollution and mortality using data from 88,615 participants in the Ontario Health Study from 2009 to 2017. They assessed exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) at participants’ residences and analyzed non-accidental, cardiovascular, and respiratory mortality risks using Cox proportional hazard models. Stronger associations were observed among physically active participants, smokers, and individuals with lower household income. These findings suggest that further improvements in air quality may reduce mortality risk, even in regions with low air pollution levels.