Dr. Guillaume Lettre is a Professor of Medicine at the Montreal Heart Institute and the Université de Montréal. He holds a Canada Research Chair in Heart and Blood Disease Genetics. He obtained his PhD in Developmental Genetics from the University of Zurich, Switzerland. His lab investigates the genetics of complex traits and common diseases in humans. Based at the Montreal Heart Institute, the Lettre Lab aims to identify genetic variation that influences cardiovascular and hematological disease risk using high-throughput DNA genotyping and sequencing technologies, together with state-of-the-art computational and bioinformatics approaches. They are also combining their genetic discoveries with functional characterization largely based on genome editing methods (e.g. CRISPR/Cas9) to gain molecular and mechanistic insights into disease pathophysiology.